Coordination strategies to improve COVID-19 PCR laboratory testing scale up in Nepal: An analysis
During the COVID-19 pandemic, Nepal rapidly expanded its PCR testing capacity, essential for effective outbreak response. However, many laboratories faced overwhelming test volumes, resulting in delays that may have hindered containment efforts. This study aims to determine whether these challenges...
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| Veröffentlicht in: | PloS one 2024-12, Vol.19 (12), p.e0314746 |
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| creator | Bakker, Hannah Govindakarnavar, Arunkumar Krishnan Krishnakumari, Parvathy Gromicho, Joaquim Côté, Fannie L Lahrichi, Nadia Jha, Priya Shrestha, Saugat Mulmi, Rashmi Bhusal, Nirajan Stapith, Deepesh Jha, Runa Shrestha, Lilee Naidoo, Dhamari Samuel, Reuben Del Rio Vilas, Victor |
| description | During the COVID-19 pandemic, Nepal rapidly expanded its PCR testing capacity, essential for effective outbreak response. However, many laboratories faced overwhelming test volumes, resulting in delays that may have hindered containment efforts. This study aims to determine whether these challenges stemmed from capacity limitations and/or imbalanced sample distribution due to inadequate coordination. In this retro-perspective simulation of SARS-CoV-2 testing in Nepal during 2021, we evaluate the impact of coordinated sample transfers on reducing laboratory stress and wait times during demand peaks. Our findings reveal that centralized coordination and strategic partnerships for sample transfers significantly enhance diagnostic network performance, even under high demand. These insights offer valuable guidance for policymakers on implementing effective coordination strategies to strengthen diagnostic networks for future pandemics. |
| doi_str_mv | 10.1371/journal.pone.0314746 |
| format | Article |
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However, many laboratories faced overwhelming test volumes, resulting in delays that may have hindered containment efforts. This study aims to determine whether these challenges stemmed from capacity limitations and/or imbalanced sample distribution due to inadequate coordination. In this retro-perspective simulation of SARS-CoV-2 testing in Nepal during 2021, we evaluate the impact of coordinated sample transfers on reducing laboratory stress and wait times during demand peaks. Our findings reveal that centralized coordination and strategic partnerships for sample transfers significantly enhance diagnostic network performance, even under high demand. These insights offer valuable guidance for policymakers on implementing effective coordination strategies to strengthen diagnostic networks for future pandemics.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0314746</identifier><identifier>PMID: 39637159</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Biology and life sciences ; Collaboration ; Computer and Information Sciences ; Coordination ; COVID-19 ; COVID-19 - diagnosis ; COVID-19 - epidemiology ; COVID-19 - virology ; COVID-19 diagnostic tests ; COVID-19 Nucleic Acid Testing - methods ; COVID-19 Testing - methods ; Diagnostic systems ; Epidemics ; Evaluation ; Health aspects ; Humans ; Laboratories ; Laboratory tests ; Medical screening ; Medicine and Health Sciences ; Methods ; Nepal ; Nepal - epidemiology ; Pandemics ; People and Places ; Performance evaluation ; Polymerase chain reaction ; Provinces ; Research and Analysis Methods ; SARS-CoV-2 - isolation & purification ; Severe acute respiratory syndrome coronavirus 2 ; Stress (Psychology) ; Stress management ; Viral diseases</subject><ispartof>PloS one, 2024-12, Vol.19 (12), p.e0314746</ispartof><rights>Copyright: © 2024 Bakker et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2024 Public Library of Science</rights><rights>2024 Bakker et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 Bakker et al 2024 Bakker et al</rights><rights>2024 Bakker et al. 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| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2024-12, Vol.19 (12), p.e0314746 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_3141380409 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Analysis Biology and life sciences Collaboration Computer and Information Sciences Coordination COVID-19 COVID-19 - diagnosis COVID-19 - epidemiology COVID-19 - virology COVID-19 diagnostic tests COVID-19 Nucleic Acid Testing - methods COVID-19 Testing - methods Diagnostic systems Epidemics Evaluation Health aspects Humans Laboratories Laboratory tests Medical screening Medicine and Health Sciences Methods Nepal Nepal - epidemiology Pandemics People and Places Performance evaluation Polymerase chain reaction Provinces Research and Analysis Methods SARS-CoV-2 - isolation & purification Severe acute respiratory syndrome coronavirus 2 Stress (Psychology) Stress management Viral diseases |
| title | Coordination strategies to improve COVID-19 PCR laboratory testing scale up in Nepal: An analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T04%3A22%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Coordination%20strategies%20to%20improve%20COVID-19%20PCR%20laboratory%20testing%20scale%20up%20in%20Nepal:%20An%20analysis&rft.jtitle=PloS%20one&rft.au=Bakker,%20Hannah&rft.date=2024-12-05&rft.volume=19&rft.issue=12&rft.spage=e0314746&rft.pages=e0314746-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0314746&rft_dat=%3Cgale_plos_%3EA819044196%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3141380409&rft_id=info:pmid/39637159&rft_galeid=A819044196&rft_doaj_id=oai_doaj_org_article_1bd8e06b8b4c4d7fa55781dfe6f26c9d&rfr_iscdi=true |