Protease-activated receptor 2 deficient mice develop less angiotensin II induced left ventricular hypertrophy but more cardiac fibrosis

Activation of Protease Activated Receptor 2 (PAR2) has been shown to be involved in regulation of injury-related processes including inflammation, fibrosis and hypertrophy. In this study we will investigate the role of PAR2 in cardiac injury in a mouse model of hypertension using continuous infusion...

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Veröffentlicht in:	PloS one 2024-12, Vol.19 (12), p.e0310095
Hauptverfasser:	Meyer Zu Schwabedissen, Albrecht, Vergarajauregui, Silvia, Bertog, Marko, Amann, Kerstin, Engel, Felix B, Daniel, Christoph
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin Angiotensin II Angiotensin II - pharmacology Animals Biology and Life Sciences Blocking antibodies Blood vessels Cardiomyocytes Care and treatment Collagen Collagen (type IV) Complications and side effects Down-regulation Experiments Fibroblast growth factor 23 Fibroblasts Fibroblasts - metabolism Fibroblasts - pathology Fibrosis Gene expression Heart Heart enlargement Hypertension Hypertrophy Hypertrophy, Left Ventricular - genetics Hypertrophy, Left Ventricular - metabolism Hypertrophy, Left Ventricular - pathology Immunohistochemistry Injuries Laboratory animals Localization Male Medicine and Health Sciences Mice Mice, Inbred C57BL Mice, Knockout Monoclonal antibodies Myocardium - metabolism Myocardium - pathology Ostomy Patient outcomes Polyclonal antibodies Protease Protease inhibitors Rats Receptor, PAR-2 - deficiency Receptor, PAR-2 - genetics Receptor, PAR-2 - metabolism Receptors Research and Analysis Methods Skin Smooth muscle Staining Ventricle
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