Evaluating the specificity of flavivirus proteases in Aedes aegypti cells for dengue virus 2-derived cleavage sites

Flaviviruses are a diverse group of RNA viruses known for their significant impact on human health worldwide. We generated a series of reporters that included cleavage sequences from the dengue virus type 2 polyprotein and co-transfected with plasmids encoding various flavivirus proteases into Aedes...

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Veröffentlicht in:	PloS one 2024-12, Vol.19 (12), p.e0309095
Hauptverfasser:	Dingle, Alexius O, Adelman, Zach N
Format:	Artikel
Sprache:	eng
Schlagworte:	Aedes - enzymology Aedes - virology Aedes aegypti Animals Apoptosis Aquatic insects Biology and Life Sciences Care and treatment Cell Line Cleavage Dengue Dengue fever Dengue Virus - enzymology Dengue Virus - genetics Dengue Virus - physiology Dengue viruses Diagnosis Encephalitis Endoplasmic reticulum Flavivirus - enzymology Flavivirus - genetics Fluoroscopic imaging Gene sequencing Genomes Genomics Infections Insecticides Insects Journalists Medicine and Health Sciences Mosquitoes Mutagenesis Peptide Hydrolases - genetics Peptide Hydrolases - metabolism Plasmids Proteases Proteins Proteolysis Research and Analysis Methods RNA viruses Substrate Specificity Vector-borne diseases Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - metabolism Viral Proteins - genetics Viral Proteins - metabolism Viruses Zika virus
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