Oral microbiome test as an alternative diagnostic tool for gastric alterations: A prospective, bicentric cross-sectional study
The human microbiome plays a pivotal role in influencing various physiological processes and maintaining overall well-being, including the gastric system. Current diagnostic tests for gastric diseases often involve invasive procedures, sampling limitations, and medication effects, leading to potenti...
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| Veröffentlicht in: | PloS one 2024-12, Vol.19 (12), p.e0314660 |
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| creator | Martins, Fernanda Prata Andrade-Silva, Jessica Teixeira, Bianca Luise Ferrari, Angelo Christoff, Ana Paula Cruz, Giuliano Netto Flores Paladino, Fernanda Vieira de Oliveira, Luiz Felipe Valter Hernandes, Camila |
| description | The human microbiome plays a pivotal role in influencing various physiological processes and maintaining overall well-being, including the gastric system. Current diagnostic tests for gastric diseases often involve invasive procedures, sampling limitations, and medication effects, leading to potential diagnostic errors and discomfort to patients. Considering the connection between oral and gastric microbiomes, this cross-sectional study aimed to assess the diagnostic potential of the oral bacterial profile in patients undergoing upper digestive endoscopy. Oral samples from 266 participants across two Brazilian sites (Belterra and Sao Paulo) were sequenced and subjected to bioinformatic analysis to identify microbiome composition across endoscopy outcome groups, exploring alpha and beta-diversity, richness, and differential abundance and prevalence. Prevotella, Haemophilus, Fusobacterium, Neisseria, and Streptococcus were the most abundant genera observed. No significant associations were found between alpha diversity profiles and endoscopy outcomes; beta diversity analyses similarly showed no correlations. Overall, the study did not establish the oral microbiome as a reliable marker for gastric health, underscoring the necessity for broader studies in the development of non-invasive diagnostic tests. |
| doi_str_mv | 10.1371/journal.pone.0314660 |
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Current diagnostic tests for gastric diseases often involve invasive procedures, sampling limitations, and medication effects, leading to potential diagnostic errors and discomfort to patients. Considering the connection between oral and gastric microbiomes, this cross-sectional study aimed to assess the diagnostic potential of the oral bacterial profile in patients undergoing upper digestive endoscopy. Oral samples from 266 participants across two Brazilian sites (Belterra and Sao Paulo) were sequenced and subjected to bioinformatic analysis to identify microbiome composition across endoscopy outcome groups, exploring alpha and beta-diversity, richness, and differential abundance and prevalence. Prevotella, Haemophilus, Fusobacterium, Neisseria, and Streptococcus were the most abundant genera observed. No significant associations were found between alpha diversity profiles and endoscopy outcomes; beta diversity analyses similarly showed no correlations. Overall, the study did not establish the oral microbiome as a reliable marker for gastric health, underscoring the necessity for broader studies in the development of non-invasive diagnostic tests.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0314660</identifier><identifier>PMID: 39621633</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aged ; Antibiotics ; Bacteria - classification ; Bacteria - genetics ; Bacteria - isolation & purification ; Bioinformatics ; Biological diversity ; Biology and Life Sciences ; Brazil ; Care and treatment ; Consent ; Cross-Sectional Studies ; Diagnosis ; Diagnostic tests ; Einstein, Albert (1879-1955) ; Endoscopy ; Evaluation ; Female ; Gastric cancer ; Gastrointestinal diseases ; Health aspects ; Humans ; Lifestyles ; Male ; Medical tests ; Medicine and Health Sciences ; Microbiomes ; Microbiota ; Microbiota (Symbiotic organisms) ; Microorganisms ; Middle Aged ; Mouth - microbiology ; Physiological aspects ; Physiological effects ; Prospective Studies ; Protons ; Research and Analysis Methods ; Social Sciences ; Sociodemographics ; Stomach - microbiology ; Stomach Diseases - diagnosis ; Stomach Diseases - microbiology ; Taxonomy ; Well being</subject><ispartof>PloS one, 2024-12, Vol.19 (12), p.e0314660</ispartof><rights>Copyright: © 2024 Martins et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2024 Public Library of Science</rights><rights>2024 Martins et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 Martins et al 2024 Martins et al</rights><rights>2024 Martins et al. 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Current diagnostic tests for gastric diseases often involve invasive procedures, sampling limitations, and medication effects, leading to potential diagnostic errors and discomfort to patients. Considering the connection between oral and gastric microbiomes, this cross-sectional study aimed to assess the diagnostic potential of the oral bacterial profile in patients undergoing upper digestive endoscopy. Oral samples from 266 participants across two Brazilian sites (Belterra and Sao Paulo) were sequenced and subjected to bioinformatic analysis to identify microbiome composition across endoscopy outcome groups, exploring alpha and beta-diversity, richness, and differential abundance and prevalence. Prevotella, Haemophilus, Fusobacterium, Neisseria, and Streptococcus were the most abundant genera observed. No significant associations were found between alpha diversity profiles and endoscopy outcomes; beta diversity analyses similarly showed no correlations. 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| subjects | Adult Aged Antibiotics Bacteria - classification Bacteria - genetics Bacteria - isolation & purification Bioinformatics Biological diversity Biology and Life Sciences Brazil Care and treatment Consent Cross-Sectional Studies Diagnosis Diagnostic tests Einstein, Albert (1879-1955) Endoscopy Evaluation Female Gastric cancer Gastrointestinal diseases Health aspects Humans Lifestyles Male Medical tests Medicine and Health Sciences Microbiomes Microbiota Microbiota (Symbiotic organisms) Microorganisms Middle Aged Mouth - microbiology Physiological aspects Physiological effects Prospective Studies Protons Research and Analysis Methods Social Sciences Sociodemographics Stomach - microbiology Stomach Diseases - diagnosis Stomach Diseases - microbiology Taxonomy Well being |
| title | Oral microbiome test as an alternative diagnostic tool for gastric alterations: A prospective, bicentric cross-sectional study |
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