Imaging analytical technique to assess gastrointestinal motility in vivo using zebrafish larvae with diabetes mellitus-like traits

In diabetes mellitus (DM), the prevalence of gastrointestinal (GI) complications, including constipation, diarrhoea, gastroparesis, and/or enteropathy, can be up to ~75%. In this study, we compared three zebrafish larvae models of DM and established an analytical protocol for GI motility. Larvae wer...

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Veröffentlicht in:	PloS one 2024-12, Vol.19 (12), p.e0314515
Hauptverfasser:	Hui, Jessica C M, Du, Peng, Webb, Sarah E, Liu, Julia Y H, Ngan, Man Piu, Lu, Zengbing, Ng, Heidi S H, Yang, Lingqing, Khalid, Aleena, Liu, Luping, Li, Zitong, Deng, Yingyi, Cui, Dexuan, Rudd, John A
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical techniques Animal experimentation Animals Anterograde transport Biology and Life Sciences Care and treatment Constipation Danio rerio Diabetes Diabetes mellitus Diabetes Mellitus - physiopathology Diagnosis Diarrhea Diet Diet, High-Fat - adverse effects Disease Models, Animal Evaluation Gastric motility Gastroesophageal reflux Gastrointestinal Motility Gastrointestinal system Glucose Glucose - metabolism Health aspects High fat diet Hyperglycemia Immune system In vivo methods and tests Insulin resistance Insulin-like growth factors Intestine Kinases Larva Larvae Medicine and Health Sciences Motility Nitric oxide Pacemakers Peptides Phenotypes Physical Sciences Research and Analysis Methods Retrograde transport Zebra fish Zebrafish
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