Effect of immortal time bias on the association between immune-related adverse events and oncological outcomes following immune checkpoint inhibitors therapy for head and neck squamous cell carcinoma

Immune checkpoint inhibitors (ICIs) are pharmacological agents indicated for recurrent and metastatic head and neck squamous cell carcinoma (HNCSCC). Immune-related adverse events (irAEs) have been reported as predictors of therapeutic response to ICIs. However, previous studies have not adequately...

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Veröffentlicht in:	PloS one 2024-11, Vol.19 (11), p.e0314209
Hauptverfasser:	Tamura, Koichi, Takenaka, Yukinori, Hosokawa, Kiyohito, Sato, Takashi, Tsuda, Takeshi, Eguchi, Hirotaka, Suzuki, Masami, Fukusumi, Takahito, Suzuki, Motoyuki, Inohara, Hidenori
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adverse events Aged Aged, 80 and over Analysis Bias Biology and life sciences Cancer Care and treatment Cell-mediated cytotoxicity Chemotherapy Cytotoxicity Development and progression Disease control Female Head & neck cancer Head and neck cancer Head and neck carcinoma Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - immunology Health aspects Hormone replacement therapy Human papillomavirus Humans Immune checkpoint inhibitors Immune Checkpoint Inhibitors - adverse effects Immune Checkpoint Inhibitors - therapeutic use Inhibitors Kaplan-Meier Estimate Male Medical prognosis Medicine and Health Sciences Metastases Middle Aged Oncology, Experimental Otolaryngology People and Places Prognosis Progression-Free Survival Proportional Hazards Models Regression analysis Research and Analysis Methods Retrospective Studies Risk factors Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck - drug therapy Squamous Cell Carcinoma of Head and Neck - immunology Statistical analysis Survival Thyroid gland Treatment Outcome
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