Pine pollen reverses the function of hepatocellular carcinoma by inhibiting α-Enolase mediated PI3K/AKT signaling pathway

This study aimed to investigate the influence of pine pollen (PP) on hepatocellular carcinoma (HCC) behavior in vitro and in vivo and explore its mechanism of action by focusing on the phosphatidylinositol 3-kinase/protein serine-threonine kinase (PI3K/AKT) signaling pathway and α-Enolase (ENO1) gen...

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Veröffentlicht in:	PloS one 2024, Vol.19 (11), p.e0312434
Hauptverfasser:	Luo, Yanhong, Guo, Chun, Ling, Caixia, Yu, Wenjun, Chen, Yuanhong, Jiang, Lihe, Luo, Qiuxiang, Wang, Chunfang, Xu, Weixin
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Alanine Alanine transaminase Animals Aspartate aminotransferase Biocompatibility Bioinformatics Biomarkers, Tumor c-Myc protein Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Line, Tumor Cell migration Cell Movement Cell Proliferation Cells Cytotoxicity DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism ErbB-2 protein Ethics Experiments Gene expression Gene Expression Regulation, Neoplastic Genes Hepatocellular carcinoma Humans In vivo methods and tests Kinases Laboratory animals Liver cancer Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Male Mice Mice, Inbred BALB C Mice, Nude Myc protein Phosphatidylinositol 3-Kinases - metabolism Phosphopyruvate hydratase Phosphopyruvate Hydratase - genetics Phosphopyruvate Hydratase - metabolism Phosphorylation Pinus Pollen Protein-serine/threonine kinase Protein-tyrosine kinase receptors Proteins Proto-Oncogene Proteins c-akt - metabolism Scratch tests Signal Transduction Toxicity testing Transaminases Transfection Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Tumors Tyrosine Xenograft Model Antitumor Assays Xenotransplantation
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