Unveiling dynamic hepatocyte plasticity in HepaRG cells with a dual CYP reporter system

Primary hepatocytes are widely utilized for investigating drug efficacy and toxicity, yet variations between batches and limited proliferation capacity present significant challenges. HepaRG cells are versatile cells, capable of maintaining an undifferentiated state and differentiating through dimet...

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Veröffentlicht in:	PloS one 2024-11, Vol.19 (11), p.e0308694
Hauptverfasser:	Asano, Riku, Iizaka, Yohei, Kashima, Makoto, Anzai, Yojiro, Yamaguchi, Shinpei, Tada, Masako
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Bile ducts Biology and Life Sciences Cell culture Cell Differentiation Cell Line Cell Plasticity - drug effects Cell Proliferation Cells CYP3A4 gene CYP3A7 protein Cytochrome P-450 Cytochrome P-450 CYP3A - genetics Cytochrome P-450 CYP3A - metabolism Cytochrome P450 Differentiation Dimethyl sulfoxide Ethylenediaminetetraacetic acid Fetuses Gas flow Gene expression Genes Genes, Reporter Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Health aspects Hepatocytes Hepatocytes - cytology Hepatocytes - metabolism Humans Inhibitors Kinases Liver Liver cells Medicine and Health Sciences Metabolism Molecular modelling Plastic properties Plasticity Pyridines Pyrimidines Research and analysis methods Toxicity Transcriptomes Transcriptomics Wnt protein
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