Effectiveness of virtual reality-based rehabilitation on the upper extremity motor function of stroke patients: A protocol for systematic review and meta-analysis
Upper extremity deficits (UED) is a common and impactful complication among stroke survivors. Virtual reality (VR)-based rehabilitation holds potential for enhancing rehabilitation intensity and engagement by stimulating tasks. While several clinical studies have examined the effectiveness and safet...
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| description | Upper extremity deficits (UED) is a common and impactful complication among stroke survivors. Virtual reality (VR)-based rehabilitation holds potential for enhancing rehabilitation intensity and engagement by stimulating tasks. While several clinical studies have examined the effectiveness and safety of VR-based rehabilitation, there is a need for further research to improve consistency in outcomes.
The study will incorporate randomized controlled trials (RCTs) concerning the effects of VR-based rehabilitation on upper extremity (UE) function in stroke survivors. A comprehensive search of databases including PubMed, Embase, Cochrane Library, Web of Science, Scopus, Cinahl, China National Knowledge Infrastructure (CNKI), Wan-fang, and Chinese Biology Medicine Database will be performed from inception to the start of the study. Primary outcomes will focus on upper limb motor function assessments such as the Fugl-Meyer Upper Extremity (FMUE), Box and Block Test (BBT), Wolf Motor Function Test (WMFT), and Action Research Arm Test (ARAT). Secondary outcomes related to activities of daily living will include the Barthel Index (BI) and Functional Independence Measure (FIM). Research selection, data extraction, and quality assessment will be independently conducted by two researchers. The recently revised Cochrane risk of bias tool will be employed to evaluate study quality. Meta-regression and subgroup analyses will be utilized to identify effective therapy delivery modes and patterns. The assessment, development, and evaluation of recommendations approach will be applied to achieve a robust conclusion.
This study provides a rigorous synthesis to evaluate optimal parameters-specifically intensity and duration-for VR-based rehabilitation interventions aimed at enhancing UE function in stroke survivors. Our secondary objective is to assess the impact of these parameters on rehabilitation outcomes. We anticipate an accurate, transparent, and standardized review process that will yield evidence-based recommendations for integrating VR technology into treating upper extremity dysfunction in stroke patients, offering clinicians effective strategies to enhance upper limb function. |
| doi_str_mv | 10.1371/journal.pone.0313296 |
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The study will incorporate randomized controlled trials (RCTs) concerning the effects of VR-based rehabilitation on upper extremity (UE) function in stroke survivors. A comprehensive search of databases including PubMed, Embase, Cochrane Library, Web of Science, Scopus, Cinahl, China National Knowledge Infrastructure (CNKI), Wan-fang, and Chinese Biology Medicine Database will be performed from inception to the start of the study. Primary outcomes will focus on upper limb motor function assessments such as the Fugl-Meyer Upper Extremity (FMUE), Box and Block Test (BBT), Wolf Motor Function Test (WMFT), and Action Research Arm Test (ARAT). Secondary outcomes related to activities of daily living will include the Barthel Index (BI) and Functional Independence Measure (FIM). Research selection, data extraction, and quality assessment will be independently conducted by two researchers. The recently revised Cochrane risk of bias tool will be employed to evaluate study quality. Meta-regression and subgroup analyses will be utilized to identify effective therapy delivery modes and patterns. The assessment, development, and evaluation of recommendations approach will be applied to achieve a robust conclusion.
This study provides a rigorous synthesis to evaluate optimal parameters-specifically intensity and duration-for VR-based rehabilitation interventions aimed at enhancing UE function in stroke survivors. Our secondary objective is to assess the impact of these parameters on rehabilitation outcomes. We anticipate an accurate, transparent, and standardized review process that will yield evidence-based recommendations for integrating VR technology into treating upper extremity dysfunction in stroke patients, offering clinicians effective strategies to enhance upper limb function.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0313296</identifier><identifier>PMID: 39509415</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Activities of Daily Living ; Analysis ; Arm ; Biology and Life Sciences ; Care and treatment ; Clinical medicine ; Clinical trials ; Computer and Information Sciences ; Computer applications ; Effectiveness ; Engineering and Technology ; Evaluation ; Health aspects ; Human motion ; Humans ; Intervention ; Medical research ; Medicine and Health Sciences ; Medicine, Experimental ; Meta-analysis ; Meta-Analysis as Topic ; Parameter identification ; Parameter robustness ; Patients ; Physical Sciences ; Quality assessment ; Quality control ; Randomized Controlled Trials as Topic ; Recovery of Function ; Rehabilitation ; Research and Analysis Methods ; Stroke ; Stroke - complications ; Stroke - physiopathology ; Stroke patients ; Stroke Rehabilitation - methods ; Study Protocol ; Subgroups ; Survival ; Systematic review ; Systematic Reviews as Topic ; Treatment Outcome ; Upper Extremity - physiopathology ; Virtual Reality</subject><ispartof>PloS one, 2024-11, Vol.19 (11), p.e0313296</ispartof><rights>Copyright: © 2024 Zhang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2024 Public Library of Science</rights><rights>2024 Zhang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 Zhang et al 2024 Zhang et al</rights><rights>2024 Zhang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c572t-8f9a09708db6290ea6abbc4946c69abb145a41817f1054b5cee4bef4c1c0825f3</cites><orcidid>0009-0006-5632-8090</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11542779/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11542779/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39509415$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Jiali</creatorcontrib><creatorcontrib>Yang, Jie</creatorcontrib><creatorcontrib>Xu, Qiuzhu</creatorcontrib><creatorcontrib>Xiao, Yan</creatorcontrib><creatorcontrib>Zuo, Liang</creatorcontrib><creatorcontrib>Cai, Enli</creatorcontrib><title>Effectiveness of virtual reality-based rehabilitation on the upper extremity motor function of stroke patients: A protocol for systematic review and meta-analysis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Upper extremity deficits (UED) is a common and impactful complication among stroke survivors. Virtual reality (VR)-based rehabilitation holds potential for enhancing rehabilitation intensity and engagement by stimulating tasks. While several clinical studies have examined the effectiveness and safety of VR-based rehabilitation, there is a need for further research to improve consistency in outcomes.
The study will incorporate randomized controlled trials (RCTs) concerning the effects of VR-based rehabilitation on upper extremity (UE) function in stroke survivors. A comprehensive search of databases including PubMed, Embase, Cochrane Library, Web of Science, Scopus, Cinahl, China National Knowledge Infrastructure (CNKI), Wan-fang, and Chinese Biology Medicine Database will be performed from inception to the start of the study. Primary outcomes will focus on upper limb motor function assessments such as the Fugl-Meyer Upper Extremity (FMUE), Box and Block Test (BBT), Wolf Motor Function Test (WMFT), and Action Research Arm Test (ARAT). Secondary outcomes related to activities of daily living will include the Barthel Index (BI) and Functional Independence Measure (FIM). Research selection, data extraction, and quality assessment will be independently conducted by two researchers. The recently revised Cochrane risk of bias tool will be employed to evaluate study quality. Meta-regression and subgroup analyses will be utilized to identify effective therapy delivery modes and patterns. The assessment, development, and evaluation of recommendations approach will be applied to achieve a robust conclusion.
This study provides a rigorous synthesis to evaluate optimal parameters-specifically intensity and duration-for VR-based rehabilitation interventions aimed at enhancing UE function in stroke survivors. Our secondary objective is to assess the impact of these parameters on rehabilitation outcomes. We anticipate an accurate, transparent, and standardized review process that will yield evidence-based recommendations for integrating VR technology into treating upper extremity dysfunction in stroke patients, offering clinicians effective strategies to enhance upper limb function.</description><subject>Activities of Daily Living</subject><subject>Analysis</subject><subject>Arm</subject><subject>Biology and Life Sciences</subject><subject>Care and treatment</subject><subject>Clinical medicine</subject><subject>Clinical trials</subject><subject>Computer and Information Sciences</subject><subject>Computer applications</subject><subject>Effectiveness</subject><subject>Engineering and Technology</subject><subject>Evaluation</subject><subject>Health aspects</subject><subject>Human motion</subject><subject>Humans</subject><subject>Intervention</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Medicine, 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Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Jiali</au><au>Yang, Jie</au><au>Xu, Qiuzhu</au><au>Xiao, Yan</au><au>Zuo, Liang</au><au>Cai, Enli</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effectiveness of virtual reality-based rehabilitation on the upper extremity motor function of stroke patients: A protocol for systematic review and meta-analysis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2024-11-07</date><risdate>2024</risdate><volume>19</volume><issue>11</issue><spage>e0313296</spage><pages>e0313296-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Upper extremity deficits (UED) is a common and impactful complication among stroke survivors. Virtual reality (VR)-based rehabilitation holds potential for enhancing rehabilitation intensity and engagement by stimulating tasks. While several clinical studies have examined the effectiveness and safety of VR-based rehabilitation, there is a need for further research to improve consistency in outcomes.
The study will incorporate randomized controlled trials (RCTs) concerning the effects of VR-based rehabilitation on upper extremity (UE) function in stroke survivors. A comprehensive search of databases including PubMed, Embase, Cochrane Library, Web of Science, Scopus, Cinahl, China National Knowledge Infrastructure (CNKI), Wan-fang, and Chinese Biology Medicine Database will be performed from inception to the start of the study. Primary outcomes will focus on upper limb motor function assessments such as the Fugl-Meyer Upper Extremity (FMUE), Box and Block Test (BBT), Wolf Motor Function Test (WMFT), and Action Research Arm Test (ARAT). Secondary outcomes related to activities of daily living will include the Barthel Index (BI) and Functional Independence Measure (FIM). Research selection, data extraction, and quality assessment will be independently conducted by two researchers. The recently revised Cochrane risk of bias tool will be employed to evaluate study quality. Meta-regression and subgroup analyses will be utilized to identify effective therapy delivery modes and patterns. The assessment, development, and evaluation of recommendations approach will be applied to achieve a robust conclusion.
This study provides a rigorous synthesis to evaluate optimal parameters-specifically intensity and duration-for VR-based rehabilitation interventions aimed at enhancing UE function in stroke survivors. Our secondary objective is to assess the impact of these parameters on rehabilitation outcomes. We anticipate an accurate, transparent, and standardized review process that will yield evidence-based recommendations for integrating VR technology into treating upper extremity dysfunction in stroke patients, offering clinicians effective strategies to enhance upper limb function.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>39509415</pmid><doi>10.1371/journal.pone.0313296</doi><tpages>e0313296</tpages><orcidid>https://orcid.org/0009-0006-5632-8090</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | PloS one, 2024-11, Vol.19 (11), p.e0313296 |
| issn | 1932-6203 1932-6203 |
| language | eng |
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| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Activities of Daily Living Analysis Arm Biology and Life Sciences Care and treatment Clinical medicine Clinical trials Computer and Information Sciences Computer applications Effectiveness Engineering and Technology Evaluation Health aspects Human motion Humans Intervention Medical research Medicine and Health Sciences Medicine, Experimental Meta-analysis Meta-Analysis as Topic Parameter identification Parameter robustness Patients Physical Sciences Quality assessment Quality control Randomized Controlled Trials as Topic Recovery of Function Rehabilitation Research and Analysis Methods Stroke Stroke - complications Stroke - physiopathology Stroke patients Stroke Rehabilitation - methods Study Protocol Subgroups Survival Systematic review Systematic Reviews as Topic Treatment Outcome Upper Extremity - physiopathology Virtual Reality |
| title | Effectiveness of virtual reality-based rehabilitation on the upper extremity motor function of stroke patients: A protocol for systematic review and meta-analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T07%3A49%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effectiveness%20of%20virtual%20reality-based%20rehabilitation%20on%20the%20upper%20extremity%20motor%20function%20of%20stroke%20patients:%20A%20protocol%20for%20systematic%20review%20and%20meta-analysis&rft.jtitle=PloS%20one&rft.au=Zhang,%20Jiali&rft.date=2024-11-07&rft.volume=19&rft.issue=11&rft.spage=e0313296&rft.pages=e0313296-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0313296&rft_dat=%3Cgale_plos_%3EA815164605%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3125995610&rft_id=info:pmid/39509415&rft_galeid=A815164605&rft_doaj_id=oai_doaj_org_article_17fc5428b64d43fd82afb9795f61425c&rfr_iscdi=true |