(-)-Epicatechin regulates endoplasmic reticulum stress and promotes ferroptosis in lung cancer cells via the PERK/eIF2α/ATF4 signaling pathway

(-)-Epicatechin (EC) is an active ingredient of Fagopyrum dibtrys (D. Don) Hara and can regulate lung cancer progression. However, the specific regulatory mechanism is poorly understood. This study explored the specific mechanism of EC in the treatment of lung cancer. H460 cells were injected subcut...

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Veröffentlicht in:	PloS one 2024-10, Vol.19 (10), p.e0313010
Hauptverfasser:	Lv, Zengbo, Liu, Peiwan, Yang, Yingyu, Ji, Jianhua, Wu, Anao, Huang, Wensheng, Zhang, Liqiong, Zhang, Zhijun, Yang, Yunkui, Li, Wenhui, Huang, Meifang
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factor 4 - metabolism Animal models Animal welfare Animals Biology and Life Sciences Calcium ions Cancer therapies Catechin - analogs & derivatives Catechin - pharmacology Cell cycle Cell Line, Tumor Cell migration Cell Movement - drug effects Cell proliferation Cell Proliferation - drug effects Cholecystokinin Drug development eIF-2 Kinase - metabolism Endoplasmic reticulum Endoplasmic Reticulum Stress - drug effects Epicatechin Eukaryotic Initiation Factor-2 - metabolism Ferroptosis Ferroptosis - drug effects Flow cytometry Humans Immunohistochemistry In vivo methods and tests Lung cancer Lung diseases Lung Neoplasms - drug therapy Lung Neoplasms - metabolism Lung Neoplasms - pathology Medical research Medicine and Health Sciences Mice Mice, Inbred BALB C Mice, Nude Mortality Prostate cancer Proteins Radiation Regulatory mechanisms (biology) Research and Analysis Methods Signal transduction Signal Transduction - drug effects Tumors Western blotting Xenograft Model Antitumor Assays
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