Monocarboxylate transporter dependent mechanism is involved in proliferation, migration, and invasion of human glioblastoma cell lines via activation of PI3K/Akt signaling pathway

Glioblastoma multiforme is one of the most common primary tumors of the central nervous system, with a very poor prognosis. Cancer cells have been observed to upregulate pH regulators, such as monocarboxylate transporters (MCTs), with an increase in MCT4 expression being observed in several malignan...

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Veröffentlicht in:	PloS one 2024-10, Vol.19 (10), p.e0312939
Hauptverfasser:	Gao, Chen, Yang, Binni, Li, Yurong, Pei, Wenjuan
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Analysis Antibodies Basigin - genetics Basigin - metabolism Biology and life sciences Brain tumors Care and treatment Carrier proteins CD147 antigen Cell activation Cell Line, Tumor Cell migration Cell Movement Cell Proliferation Central nervous system Colorimetry Development and progression Drug delivery Gene expression Glioblastoma Glioblastoma - genetics Glioblastoma - metabolism Glioblastoma - pathology Glioblastoma multiforme Glioma Glioma cells Glycolysis Growth factors Health aspects Humans Invasiveness Kinases Malignancy Medicine and Health Sciences Metabolism Monocarboxylic Acid Transporters - genetics Monocarboxylic Acid Transporters - metabolism Muscle Proteins - genetics Muscle Proteins - metabolism Neoplasm Invasiveness Phosphatidylinositol 3-Kinases - metabolism Prognosis Protein kinases Proteins Proto-Oncogene Proteins c-akt - metabolism Research and Analysis Methods Risk factors RNA Signal Transduction siRNA Variance analysis Vascular endothelial growth factor Western blotting Wound healing
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