Alterations in aortic elasticity indices among type 2 diabetes patients in a low and middle income country using M-mode echocardiography: A cross-sectional comparative study
Diabetes is one of the leading causes of noncommunicable diseases worldwide. It is known to induce cardiovascular remodeling, which can result in a variety of complications, including a considerable increase in aortic stiffness. While studies in Western populations have explored these effects, data...
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| Veröffentlicht in: | PloS one 2024-10, Vol.19 (10), p.e0305799 |
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| creator | Dang, Hai Nguyen Ngoc Luong, Thang Viet Nguyen Khoi, Quan Nguyen, Uyen Ngoc Phuong Pham, Nguyen Nguyen Khoi Tran, Hieu Thi Nguyen Tran, Hung Khanh Cao, Mai Thi Thu Ho, Binh Anh Doan, Thang Chi Nguyen, Hung Minh Anh Hoang, Tien Van Huynh, Minh |
| description | Diabetes is one of the leading causes of noncommunicable diseases worldwide. It is known to induce cardiovascular remodeling, which can result in a variety of complications, including a considerable increase in aortic stiffness. While studies in Western populations have explored these effects, data on Asians, mainly Vietnamese, are limited. This study aimed to assess aortic elasticity in type 2 diabetes mellitus (T2DM) patients compared to healthy individuals.
This quantitative, cross-sectional study compared aortic elasticity indices between individuals with T2DM and healthy controls in Vietnam. Aortic elasticity indices were assessed for all participants using M-mode echocardiography.
A comparison between the healthy and T2DM groups revealed substantial differences in aortic elasticity indices. The aortic stiffness index (ASI) was significantly greater in the T2DM group than in the control group, with median values of 6.10 (3.64-12.47) and 3.79 (2.40-8.50), respectively (p = 0.003). Aortic strain (AS) was substantially lower in the T2DM group than in the control group, with median values of 8.21% (4.24-13.07) and 10.66% (6.01-18.23), respectively (p = 0.039). Furthermore, the median aortic compliance (AC, 10-2mm/mmHg) and aortic distensibility (AD, 10-3mmHg-1) in individuals with T2DM were 4.07 (2.28-7.44) and 3.08 (1.57-5.26), respectively, lower than those in the control group, with median values of 6.40 (3.08-10.75) and 5.33 (2.80-9.79). A longer diabetes duration was linked to a greater ASI (r = 0.43, p < 0.05), while the AS decreased (r = -0.37, p < 0.05).
Substantial variations in aorta elasticity indices were found in patients with T2DM using M-mode echocardiography. These differences highlight the impact of T2DM on vascular health. More research is needed to investigate the consequences of these discrepancies and their significance for clinical purposes. |
| doi_str_mv | 10.1371/journal.pone.0305799 |
| format | Article |
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This quantitative, cross-sectional study compared aortic elasticity indices between individuals with T2DM and healthy controls in Vietnam. Aortic elasticity indices were assessed for all participants using M-mode echocardiography.
A comparison between the healthy and T2DM groups revealed substantial differences in aortic elasticity indices. The aortic stiffness index (ASI) was significantly greater in the T2DM group than in the control group, with median values of 6.10 (3.64-12.47) and 3.79 (2.40-8.50), respectively (p = 0.003). Aortic strain (AS) was substantially lower in the T2DM group than in the control group, with median values of 8.21% (4.24-13.07) and 10.66% (6.01-18.23), respectively (p = 0.039). Furthermore, the median aortic compliance (AC, 10-2mm/mmHg) and aortic distensibility (AD, 10-3mmHg-1) in individuals with T2DM were 4.07 (2.28-7.44) and 3.08 (1.57-5.26), respectively, lower than those in the control group, with median values of 6.40 (3.08-10.75) and 5.33 (2.80-9.79). A longer diabetes duration was linked to a greater ASI (r = 0.43, p < 0.05), while the AS decreased (r = -0.37, p < 0.05).
Substantial variations in aorta elasticity indices were found in patients with T2DM using M-mode echocardiography. These differences highlight the impact of T2DM on vascular health. More research is needed to investigate the consequences of these discrepancies and their significance for clinical purposes.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0305799</identifier><identifier>PMID: 39446822</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aged ; Aorta ; Aorta - diagnostic imaging ; Aorta - physiopathology ; Biology and life sciences ; Blood pressure ; Body mass index ; Case-Control Studies ; Comparative analysis ; Comparative studies ; Coronary vessels ; Cross-Sectional Studies ; Data collection ; Developing countries ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - diagnostic imaging ; Diabetes Mellitus, Type 2 - physiopathology ; Disease ; Echocardiography ; Echocardiography - methods ; Elasticity ; Fatalities ; Female ; Generalized linear models ; Health aspects ; Heart ; Humans ; Male ; Medical research ; Medicine and Health Sciences ; Medicine, Experimental ; Middle Aged ; Missing data ; Patients ; Pharmacy ; Physical Sciences ; Physiological aspects ; Population studies ; Research and Analysis Methods ; Social aspects ; Standard deviation ; Statistical analysis ; Stiffness ; Type 2 diabetes ; Ultrasonic imaging ; Variables ; Vascular Stiffness - physiology ; Vietnam</subject><ispartof>PloS one, 2024-10, Vol.19 (10), p.e0305799</ispartof><rights>Copyright: © 2024 Dang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2024 Public Library of Science</rights><rights>2024 Dang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 Dang et al 2024 Dang et al</rights><rights>2024 Dang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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It is known to induce cardiovascular remodeling, which can result in a variety of complications, including a considerable increase in aortic stiffness. While studies in Western populations have explored these effects, data on Asians, mainly Vietnamese, are limited. This study aimed to assess aortic elasticity in type 2 diabetes mellitus (T2DM) patients compared to healthy individuals.
This quantitative, cross-sectional study compared aortic elasticity indices between individuals with T2DM and healthy controls in Vietnam. Aortic elasticity indices were assessed for all participants using M-mode echocardiography.
A comparison between the healthy and T2DM groups revealed substantial differences in aortic elasticity indices. The aortic stiffness index (ASI) was significantly greater in the T2DM group than in the control group, with median values of 6.10 (3.64-12.47) and 3.79 (2.40-8.50), respectively (p = 0.003). Aortic strain (AS) was substantially lower in the T2DM group than in the control group, with median values of 8.21% (4.24-13.07) and 10.66% (6.01-18.23), respectively (p = 0.039). Furthermore, the median aortic compliance (AC, 10-2mm/mmHg) and aortic distensibility (AD, 10-3mmHg-1) in individuals with T2DM were 4.07 (2.28-7.44) and 3.08 (1.57-5.26), respectively, lower than those in the control group, with median values of 6.40 (3.08-10.75) and 5.33 (2.80-9.79). A longer diabetes duration was linked to a greater ASI (r = 0.43, p < 0.05), while the AS decreased (r = -0.37, p < 0.05).
Substantial variations in aorta elasticity indices were found in patients with T2DM using M-mode echocardiography. These differences highlight the impact of T2DM on vascular health. More research is needed to investigate the consequences of these discrepancies and their significance for clinical purposes.</description><subject>Adult</subject><subject>Aged</subject><subject>Aorta</subject><subject>Aorta - diagnostic imaging</subject><subject>Aorta - physiopathology</subject><subject>Biology and life sciences</subject><subject>Blood pressure</subject><subject>Body mass index</subject><subject>Case-Control Studies</subject><subject>Comparative analysis</subject><subject>Comparative studies</subject><subject>Coronary vessels</subject><subject>Cross-Sectional Studies</subject><subject>Data collection</subject><subject>Developing countries</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes Mellitus, Type 2 - diagnostic imaging</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Disease</subject><subject>Echocardiography</subject><subject>Echocardiography - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dang, Hai Nguyen Ngoc</au><au>Luong, Thang Viet</au><au>Nguyen Khoi, Quan</au><au>Nguyen, Uyen Ngoc Phuong</au><au>Pham, Nguyen Nguyen Khoi</au><au>Tran, Hieu Thi Nguyen</au><au>Tran, Hung Khanh</au><au>Cao, Mai Thi Thu</au><au>Ho, Binh Anh</au><au>Doan, Thang Chi</au><au>Nguyen, Hung Minh</au><au>Anh Hoang, Tien</au><au>Van Huynh, Minh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alterations in aortic elasticity indices among type 2 diabetes patients in a low and middle income country using M-mode echocardiography: A cross-sectional comparative study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2024-10-24</date><risdate>2024</risdate><volume>19</volume><issue>10</issue><spage>e0305799</spage><pages>e0305799-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Diabetes is one of the leading causes of noncommunicable diseases worldwide. It is known to induce cardiovascular remodeling, which can result in a variety of complications, including a considerable increase in aortic stiffness. While studies in Western populations have explored these effects, data on Asians, mainly Vietnamese, are limited. This study aimed to assess aortic elasticity in type 2 diabetes mellitus (T2DM) patients compared to healthy individuals.
This quantitative, cross-sectional study compared aortic elasticity indices between individuals with T2DM and healthy controls in Vietnam. Aortic elasticity indices were assessed for all participants using M-mode echocardiography.
A comparison between the healthy and T2DM groups revealed substantial differences in aortic elasticity indices. The aortic stiffness index (ASI) was significantly greater in the T2DM group than in the control group, with median values of 6.10 (3.64-12.47) and 3.79 (2.40-8.50), respectively (p = 0.003). Aortic strain (AS) was substantially lower in the T2DM group than in the control group, with median values of 8.21% (4.24-13.07) and 10.66% (6.01-18.23), respectively (p = 0.039). Furthermore, the median aortic compliance (AC, 10-2mm/mmHg) and aortic distensibility (AD, 10-3mmHg-1) in individuals with T2DM were 4.07 (2.28-7.44) and 3.08 (1.57-5.26), respectively, lower than those in the control group, with median values of 6.40 (3.08-10.75) and 5.33 (2.80-9.79). A longer diabetes duration was linked to a greater ASI (r = 0.43, p < 0.05), while the AS decreased (r = -0.37, p < 0.05).
Substantial variations in aorta elasticity indices were found in patients with T2DM using M-mode echocardiography. These differences highlight the impact of T2DM on vascular health. More research is needed to investigate the consequences of these discrepancies and their significance for clinical purposes.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>39446822</pmid><doi>10.1371/journal.pone.0305799</doi><orcidid>https://orcid.org/0009-0008-5109-9115</orcidid><orcidid>https://orcid.org/0000-0002-7406-9604</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2024-10, Vol.19 (10), p.e0305799 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_3120495096 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adult Aged Aorta Aorta - diagnostic imaging Aorta - physiopathology Biology and life sciences Blood pressure Body mass index Case-Control Studies Comparative analysis Comparative studies Coronary vessels Cross-Sectional Studies Data collection Developing countries Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - diagnostic imaging Diabetes Mellitus, Type 2 - physiopathology Disease Echocardiography Echocardiography - methods Elasticity Fatalities Female Generalized linear models Health aspects Heart Humans Male Medical research Medicine and Health Sciences Medicine, Experimental Middle Aged Missing data Patients Pharmacy Physical Sciences Physiological aspects Population studies Research and Analysis Methods Social aspects Standard deviation Statistical analysis Stiffness Type 2 diabetes Ultrasonic imaging Variables Vascular Stiffness - physiology Vietnam |
| title | Alterations in aortic elasticity indices among type 2 diabetes patients in a low and middle income country using M-mode echocardiography: A cross-sectional comparative study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-20T20%3A02%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Alterations%20in%20aortic%20elasticity%20indices%20among%20type%202%20diabetes%20patients%20in%20a%20low%20and%20middle%20income%20country%20using%20M-mode%20echocardiography:%20A%20cross-sectional%20comparative%20study&rft.jtitle=PloS%20one&rft.au=Dang,%20Hai%20Nguyen%20Ngoc&rft.date=2024-10-24&rft.volume=19&rft.issue=10&rft.spage=e0305799&rft.pages=e0305799-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0305799&rft_dat=%3Cgale_plos_%3EA813480625%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3120495096&rft_id=info:pmid/39446822&rft_galeid=A813480625&rfr_iscdi=true |