Effects of insulin resistance and β-cell function on diabetic complications in Korean diabetic patients
Diabetes mellitus is characterized by insulin resistance (IR) and dysfunctional insulin secretion from pancreatic β-cells. However, little research has been conducted on the relationship between IR and β-cell function in relation to diabetic complications among Korean diabetic patients. This study a...
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| description | Diabetes mellitus is characterized by insulin resistance (IR) and dysfunctional insulin secretion from pancreatic β-cells. However, little research has been conducted on the relationship between IR and β-cell function in relation to diabetic complications among Korean diabetic patients. This study aimed to examine the differential associations between IR and β-cell function and various diabetic complications among Korean diabetic patients.
The analysis employed a common data model (CDM). IR and β-cell function were quantified using the homeostasis model assessment for insulin resistance (HOMA-IR) and β-cell function (HOMA-β), respectively. Hazard ratios for diabetic nephropathy, diabetic retinopathy, and cardiovascular disease (CVD) events were calculated.
The study cohort consisted of 2,034 diabetic patients aged over 20 years who visited EUMC between January 2001 and December 2019. Among diabetic patients in the highest quartile of HOMA-IR, the adjusted hazard ratio for total CVD events was 1.76 (95% confidence interval [CI], 1.20-2.57) compared with those in the lowest quartile of HOMA-IR (P = 0.004). In contrast, diabetic patients in the lowest quartile of HOMA-β exhibited an adjusted hazard ratio of 3.91 (95% CI, 1.80-8.49) for diabetic retinopathy compared to those in the highest quartile of HOMA-β (P = 0.001).
Insulin resistance and β-cell function exhibited different associations with diabetic complications among Korean diabetic patients. Specifically, lower β-cell function was associated with an increased risk of diabetic retinopathy, whereas higher IR was associated with an increased risk of CVD events. Individuals with pronounced IR should prioritize CVD prevention measures, and those with significant β-cell dysfunction may benefit from early, intensive surveillance for diabetic retinopathy. |
| doi_str_mv | 10.1371/journal.pone.0312439 |
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The analysis employed a common data model (CDM). IR and β-cell function were quantified using the homeostasis model assessment for insulin resistance (HOMA-IR) and β-cell function (HOMA-β), respectively. Hazard ratios for diabetic nephropathy, diabetic retinopathy, and cardiovascular disease (CVD) events were calculated.
The study cohort consisted of 2,034 diabetic patients aged over 20 years who visited EUMC between January 2001 and December 2019. Among diabetic patients in the highest quartile of HOMA-IR, the adjusted hazard ratio for total CVD events was 1.76 (95% confidence interval [CI], 1.20-2.57) compared with those in the lowest quartile of HOMA-IR (P = 0.004). In contrast, diabetic patients in the lowest quartile of HOMA-β exhibited an adjusted hazard ratio of 3.91 (95% CI, 1.80-8.49) for diabetic retinopathy compared to those in the highest quartile of HOMA-β (P = 0.001).
Insulin resistance and β-cell function exhibited different associations with diabetic complications among Korean diabetic patients. Specifically, lower β-cell function was associated with an increased risk of diabetic retinopathy, whereas higher IR was associated with an increased risk of CVD events. Individuals with pronounced IR should prioritize CVD prevention measures, and those with significant β-cell dysfunction may benefit from early, intensive surveillance for diabetic retinopathy.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0312439</identifier><identifier>PMID: 39436903</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Age ; Aged ; Antidiabetics ; Antihypertensives ; Beta cells ; Biology and Life Sciences ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - etiology ; Cholesterol ; Diabetes ; Diabetes Complications - epidemiology ; Diabetes mellitus ; Diabetes Mellitus, Type 2 - complications ; Diabetic Nephropathies - epidemiology ; Diabetic Nephropathies - etiology ; Diabetic nephropathy ; Diabetic retinopathy ; Diabetic Retinopathy - epidemiology ; Diabetic Retinopathy - etiology ; Electronic health records ; Female ; Gender ; Glucose ; Heart diseases ; Homeostasis ; Hospitals ; Humans ; Insulin ; Insulin Resistance ; Insulin secretion ; Insulin-Secreting Cells - metabolism ; Kidney diseases ; Lipoproteins ; Male ; Medicine and Health Sciences ; Middle Aged ; Nephropathy ; Peptides ; Plasma ; Quartiles ; Republic of Korea - epidemiology ; Retinopathy ; Sensitivity analysis ; Stroke ; Triglycerides ; Vein & artery diseases</subject><ispartof>PloS one, 2024-10, Vol.19 (10), p.e0312439</ispartof><rights>Copyright: © 2024 Song et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>2024 Song et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 Song et al 2024 Song et al</rights><rights>2024 Song et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c294t-95f5b83def08bfc02270546ed9cbb7afd8d5616e919b1bf713437a0948a500743</cites><orcidid>0000-0003-4446-6470 ; 0000-0003-2101-6661</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11495573/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11495573/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39436903$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Mahmoodi, Mohammad Reza</contributor><creatorcontrib>Song, Do Kyeong</creatorcontrib><creatorcontrib>Hong, Young Sun</creatorcontrib><creatorcontrib>Sung, Yeon-Ah</creatorcontrib><creatorcontrib>Lee, Hyejin</creatorcontrib><title>Effects of insulin resistance and β-cell function on diabetic complications in Korean diabetic patients</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Diabetes mellitus is characterized by insulin resistance (IR) and dysfunctional insulin secretion from pancreatic β-cells. However, little research has been conducted on the relationship between IR and β-cell function in relation to diabetic complications among Korean diabetic patients. This study aimed to examine the differential associations between IR and β-cell function and various diabetic complications among Korean diabetic patients.
The analysis employed a common data model (CDM). IR and β-cell function were quantified using the homeostasis model assessment for insulin resistance (HOMA-IR) and β-cell function (HOMA-β), respectively. Hazard ratios for diabetic nephropathy, diabetic retinopathy, and cardiovascular disease (CVD) events were calculated.
The study cohort consisted of 2,034 diabetic patients aged over 20 years who visited EUMC between January 2001 and December 2019. Among diabetic patients in the highest quartile of HOMA-IR, the adjusted hazard ratio for total CVD events was 1.76 (95% confidence interval [CI], 1.20-2.57) compared with those in the lowest quartile of HOMA-IR (P = 0.004). In contrast, diabetic patients in the lowest quartile of HOMA-β exhibited an adjusted hazard ratio of 3.91 (95% CI, 1.80-8.49) for diabetic retinopathy compared to those in the highest quartile of HOMA-β (P = 0.001).
Insulin resistance and β-cell function exhibited different associations with diabetic complications among Korean diabetic patients. Specifically, lower β-cell function was associated with an increased risk of diabetic retinopathy, whereas higher IR was associated with an increased risk of CVD events. Individuals with pronounced IR should prioritize CVD prevention measures, and those with significant β-cell dysfunction may benefit from early, intensive surveillance for diabetic retinopathy.</description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Antidiabetics</subject><subject>Antihypertensives</subject><subject>Beta cells</subject><subject>Biology and Life Sciences</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Cholesterol</subject><subject>Diabetes</subject><subject>Diabetes Complications - epidemiology</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetic Nephropathies - epidemiology</subject><subject>Diabetic Nephropathies - etiology</subject><subject>Diabetic nephropathy</subject><subject>Diabetic retinopathy</subject><subject>Diabetic Retinopathy - epidemiology</subject><subject>Diabetic Retinopathy - etiology</subject><subject>Electronic health records</subject><subject>Female</subject><subject>Gender</subject><subject>Glucose</subject><subject>Heart diseases</subject><subject>Homeostasis</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin Resistance</subject><subject>Insulin secretion</subject><subject>Insulin-Secreting Cells - metabolism</subject><subject>Kidney diseases</subject><subject>Lipoproteins</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Nephropathy</subject><subject>Peptides</subject><subject>Plasma</subject><subject>Quartiles</subject><subject>Republic of Korea - epidemiology</subject><subject>Retinopathy</subject><subject>Sensitivity analysis</subject><subject>Stroke</subject><subject>Triglycerides</subject><subject>Vein & artery diseases</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptUc1KJDEYDKKo6-4biAb24qVnk85Pd04ig67iwF70HNLpRCM9SZt0C77WPojPZIbpkVGEQAJVX32VKgCOMZphUuE_T2GMXnWzPngzQwSXlIgdcIgFKQteIrK79T4AP1J6QoiRmvN9cEAEJVwgcggeL601ekgwWOh8GjvnYTTJpUF5baDyLXz7X2jTddCOXg8ueJhP61RjBqehDsu-c1qtgJQV4G2IRm0R-gwZP6SfYM-qLplf030E7q8u7-bXxeLf35v5xaLQpaBDIZhlTU1aY1HdWI3KskKMctMK3TSVsm3dMo65EVg0uLEVJpRUCglaK4ZQRckROF3r9l1IcgopSYKx4DmlWmTG-cQYm6VpdXYXVSf76JYqvsqgnPyMePcoH8KLxJgKxiqSFc4mhRieR5MGuXRplZHyJozrZVWJuWCZ-vsL9XtLdM3SMaQUjf1wg5Fctb2Zkqu25dR2HjvZ_snH0KZe8g6yoaqD</recordid><startdate>20241022</startdate><enddate>20241022</enddate><creator>Song, Do Kyeong</creator><creator>Hong, Young Sun</creator><creator>Sung, Yeon-Ah</creator><creator>Lee, Hyejin</creator><general>Public Library of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4446-6470</orcidid><orcidid>https://orcid.org/0000-0003-2101-6661</orcidid></search><sort><creationdate>20241022</creationdate><title>Effects of insulin resistance and β-cell function on diabetic complications in Korean diabetic patients</title><author>Song, Do Kyeong ; Hong, Young Sun ; Sung, Yeon-Ah ; Lee, Hyejin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c294t-95f5b83def08bfc02270546ed9cbb7afd8d5616e919b1bf713437a0948a500743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Antidiabetics</topic><topic>Antihypertensives</topic><topic>Beta cells</topic><topic>Biology and Life Sciences</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Cholesterol</topic><topic>Diabetes</topic><topic>Diabetes Complications - epidemiology</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetic Nephropathies - epidemiology</topic><topic>Diabetic Nephropathies - etiology</topic><topic>Diabetic nephropathy</topic><topic>Diabetic retinopathy</topic><topic>Diabetic Retinopathy - epidemiology</topic><topic>Diabetic Retinopathy - etiology</topic><topic>Electronic health records</topic><topic>Female</topic><topic>Gender</topic><topic>Glucose</topic><topic>Heart diseases</topic><topic>Homeostasis</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Insulin</topic><topic>Insulin Resistance</topic><topic>Insulin secretion</topic><topic>Insulin-Secreting Cells - metabolism</topic><topic>Kidney diseases</topic><topic>Lipoproteins</topic><topic>Male</topic><topic>Medicine and Health Sciences</topic><topic>Middle Aged</topic><topic>Nephropathy</topic><topic>Peptides</topic><topic>Plasma</topic><topic>Quartiles</topic><topic>Republic of Korea - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Song, Do Kyeong</au><au>Hong, Young Sun</au><au>Sung, Yeon-Ah</au><au>Lee, Hyejin</au><au>Mahmoodi, Mohammad Reza</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of insulin resistance and β-cell function on diabetic complications in Korean diabetic patients</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2024-10-22</date><risdate>2024</risdate><volume>19</volume><issue>10</issue><spage>e0312439</spage><pages>e0312439-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Diabetes mellitus is characterized by insulin resistance (IR) and dysfunctional insulin secretion from pancreatic β-cells. However, little research has been conducted on the relationship between IR and β-cell function in relation to diabetic complications among Korean diabetic patients. This study aimed to examine the differential associations between IR and β-cell function and various diabetic complications among Korean diabetic patients.
The analysis employed a common data model (CDM). IR and β-cell function were quantified using the homeostasis model assessment for insulin resistance (HOMA-IR) and β-cell function (HOMA-β), respectively. Hazard ratios for diabetic nephropathy, diabetic retinopathy, and cardiovascular disease (CVD) events were calculated.
The study cohort consisted of 2,034 diabetic patients aged over 20 years who visited EUMC between January 2001 and December 2019. Among diabetic patients in the highest quartile of HOMA-IR, the adjusted hazard ratio for total CVD events was 1.76 (95% confidence interval [CI], 1.20-2.57) compared with those in the lowest quartile of HOMA-IR (P = 0.004). In contrast, diabetic patients in the lowest quartile of HOMA-β exhibited an adjusted hazard ratio of 3.91 (95% CI, 1.80-8.49) for diabetic retinopathy compared to those in the highest quartile of HOMA-β (P = 0.001).
Insulin resistance and β-cell function exhibited different associations with diabetic complications among Korean diabetic patients. Specifically, lower β-cell function was associated with an increased risk of diabetic retinopathy, whereas higher IR was associated with an increased risk of CVD events. Individuals with pronounced IR should prioritize CVD prevention measures, and those with significant β-cell dysfunction may benefit from early, intensive surveillance for diabetic retinopathy.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>39436903</pmid><doi>10.1371/journal.pone.0312439</doi><orcidid>https://orcid.org/0000-0003-4446-6470</orcidid><orcidid>https://orcid.org/0000-0003-2101-6661</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Aged Antidiabetics Antihypertensives Beta cells Biology and Life Sciences Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Cholesterol Diabetes Diabetes Complications - epidemiology Diabetes mellitus Diabetes Mellitus, Type 2 - complications Diabetic Nephropathies - epidemiology Diabetic Nephropathies - etiology Diabetic nephropathy Diabetic retinopathy Diabetic Retinopathy - epidemiology Diabetic Retinopathy - etiology Electronic health records Female Gender Glucose Heart diseases Homeostasis Hospitals Humans Insulin Insulin Resistance Insulin secretion Insulin-Secreting Cells - metabolism Kidney diseases Lipoproteins Male Medicine and Health Sciences Middle Aged Nephropathy Peptides Plasma Quartiles Republic of Korea - epidemiology Retinopathy Sensitivity analysis Stroke Triglycerides Vein & artery diseases |
| title | Effects of insulin resistance and β-cell function on diabetic complications in Korean diabetic patients |
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