Time to recovery from necrotizing enterocolitis and its predictors among neonates admitted to Neonatal Intensive Care Unit in Bahir Dar, Ethiopia: A retrospective follow up study, 2022
Necrotizing enterocolitis is one of the most common, life-threatening, gastrointestinal disorders in neonates. The recovery time for neonates with NEC varies depending on disease severity, prompt diagnosis, and effective treatment. Therefore, this study was intended to assess the time to recover fro...
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| description | Necrotizing enterocolitis is one of the most common, life-threatening, gastrointestinal disorders in neonates. The recovery time for neonates with NEC varies depending on disease severity, prompt diagnosis, and effective treatment. Therefore, this study was intended to assess the time to recover from necrotizing enterocolitis and its' predictors among neonates admitted to Neonatal Intensive Care Unit in Bahir Dar City, Ethiopia.
An institution-based retrospective follow-up study design was employed. A sample of 361 medical records of neonates with necrotizing enterocolitis was selected using systematic random sampling. Diagnosis of NEC in this study required clinical, laboratory and radiographic findings. The survival function was described using Kaplan Meier survival curve and log-rank test. Bivariate and multivariate Cox-proportional hazard (Cox-PH) regression models were used for analysis.
The median recovery time from necrotizing enterocolitis for neonates in the neonatal intensive care unit was 12 days. The multivariable Cox-PH model showed that neonates classified as Stage III NEC (AHR: 0.42, 95% CI = 0.23-0.77) and those exposed to perinatal asphyxia (AHR: 0.51, 95% CI: 0.35-0.74) had a negative impact on NEC recovery time. However, neonates with a birth weight of 1500-2499gm (AHR: 1.65, 95% CI: 1.05-2.58) and a platelet count greater than 150,000 (AHR: 1.75, 95% CI: 1.24-2.48) had a positive effect on NEC recovery time.
The recovery time for neonates in the neonatal intensive care unit with necrotizing enterocolitis was longer. Comorbidities and advanced stage of NEC were associated with prolonged recovery time from NEC. However, neonates with better platelet count and birth weight greater than 1500mg had shorter recovery time from NEC. |
| doi_str_mv | 10.1371/journal.pone.0311890 |
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An institution-based retrospective follow-up study design was employed. A sample of 361 medical records of neonates with necrotizing enterocolitis was selected using systematic random sampling. Diagnosis of NEC in this study required clinical, laboratory and radiographic findings. The survival function was described using Kaplan Meier survival curve and log-rank test. Bivariate and multivariate Cox-proportional hazard (Cox-PH) regression models were used for analysis.
The median recovery time from necrotizing enterocolitis for neonates in the neonatal intensive care unit was 12 days. The multivariable Cox-PH model showed that neonates classified as Stage III NEC (AHR: 0.42, 95% CI = 0.23-0.77) and those exposed to perinatal asphyxia (AHR: 0.51, 95% CI: 0.35-0.74) had a negative impact on NEC recovery time. However, neonates with a birth weight of 1500-2499gm (AHR: 1.65, 95% CI: 1.05-2.58) and a platelet count greater than 150,000 (AHR: 1.75, 95% CI: 1.24-2.48) had a positive effect on NEC recovery time.
The recovery time for neonates in the neonatal intensive care unit with necrotizing enterocolitis was longer. Comorbidities and advanced stage of NEC were associated with prolonged recovery time from NEC. However, neonates with better platelet count and birth weight greater than 1500mg had shorter recovery time from NEC.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0311890</identifier><identifier>PMID: 39436945</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Apgar score ; Asphyxia ; Biology and Life Sciences ; Birth weight ; Bivariate analysis ; Care and treatment ; Comorbidity ; Developing countries ; Diagnosis ; Enteral nutrition ; Enterocolitis ; Enterocolitis, Necrotizing - epidemiology ; Enterocolitis, Neonatal necrotizing ; Enterocolitis, Pseudomembranous ; Ethiopia - epidemiology ; Female ; Follow-Up Studies ; Gastrointestinal diseases ; Gestational age ; Health aspects ; Hospitals ; Humans ; Infant, Newborn ; Infants (Newborn) ; Intensive Care Units, Neonatal ; LDCs ; Male ; Medical records ; Medicine and Health Sciences ; Necrotizing enterocolitis ; Neonates ; Patient outcomes ; Platelets ; Population ; Random sampling ; Rank tests ; Recovery time ; Regression analysis ; Regression models ; Retrospective Studies ; Risk factors ; Standard scores ; Statistical sampling ; Survival ; Thrombocytopenia ; Time Factors</subject><ispartof>PloS one, 2024-10, Vol.19 (10), p.e0311890</ispartof><rights>Copyright: © 2024 Tefera et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2024 Public Library of Science</rights><rights>2024 Tefera et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 Tefera et al 2024 Tefera et al</rights><rights>2024 Tefera et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c460t-7cb22def6d4bc703bdfb747620f78686cec83d6413398be1a0a84b1614d30bd73</cites><orcidid>0000-0003-0264-5227</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11495620/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11495620/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39436945$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Dey, Sanjoy Kumer</contributor><creatorcontrib>Tefera, Birtukan Ayana</creatorcontrib><creatorcontrib>Ahmed, Abdurahman Mohammed</creatorcontrib><creatorcontrib>Yehualashet, Sisay Shewasinad</creatorcontrib><title>Time to recovery from necrotizing enterocolitis and its predictors among neonates admitted to Neonatal Intensive Care Unit in Bahir Dar, Ethiopia: A retrospective follow up study, 2022</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Necrotizing enterocolitis is one of the most common, life-threatening, gastrointestinal disorders in neonates. The recovery time for neonates with NEC varies depending on disease severity, prompt diagnosis, and effective treatment. Therefore, this study was intended to assess the time to recover from necrotizing enterocolitis and its' predictors among neonates admitted to Neonatal Intensive Care Unit in Bahir Dar City, Ethiopia.
An institution-based retrospective follow-up study design was employed. A sample of 361 medical records of neonates with necrotizing enterocolitis was selected using systematic random sampling. Diagnosis of NEC in this study required clinical, laboratory and radiographic findings. The survival function was described using Kaplan Meier survival curve and log-rank test. Bivariate and multivariate Cox-proportional hazard (Cox-PH) regression models were used for analysis.
The median recovery time from necrotizing enterocolitis for neonates in the neonatal intensive care unit was 12 days. The multivariable Cox-PH model showed that neonates classified as Stage III NEC (AHR: 0.42, 95% CI = 0.23-0.77) and those exposed to perinatal asphyxia (AHR: 0.51, 95% CI: 0.35-0.74) had a negative impact on NEC recovery time. However, neonates with a birth weight of 1500-2499gm (AHR: 1.65, 95% CI: 1.05-2.58) and a platelet count greater than 150,000 (AHR: 1.75, 95% CI: 1.24-2.48) had a positive effect on NEC recovery time.
The recovery time for neonates in the neonatal intensive care unit with necrotizing enterocolitis was longer. Comorbidities and advanced stage of NEC were associated with prolonged recovery time from NEC. However, neonates with better platelet count and birth weight greater than 1500mg had shorter recovery time from NEC.</description><subject>Apgar score</subject><subject>Asphyxia</subject><subject>Biology and Life Sciences</subject><subject>Birth weight</subject><subject>Bivariate analysis</subject><subject>Care and treatment</subject><subject>Comorbidity</subject><subject>Developing countries</subject><subject>Diagnosis</subject><subject>Enteral nutrition</subject><subject>Enterocolitis</subject><subject>Enterocolitis, Necrotizing - epidemiology</subject><subject>Enterocolitis, Neonatal necrotizing</subject><subject>Enterocolitis, Pseudomembranous</subject><subject>Ethiopia - epidemiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastrointestinal diseases</subject><subject>Gestational age</subject><subject>Health aspects</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infants (Newborn)</subject><subject>Intensive Care Units, Neonatal</subject><subject>LDCs</subject><subject>Male</subject><subject>Medical records</subject><subject>Medicine and Health Sciences</subject><subject>Necrotizing enterocolitis</subject><subject>Neonates</subject><subject>Patient outcomes</subject><subject>Platelets</subject><subject>Population</subject><subject>Random sampling</subject><subject>Rank tests</subject><subject>Recovery time</subject><subject>Regression analysis</subject><subject>Regression models</subject><subject>Retrospective Studies</subject><subject>Risk factors</subject><subject>Standard scores</subject><subject>Statistical sampling</subject><subject>Survival</subject><subject>Thrombocytopenia</subject><subject>Time 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tefera, Birtukan Ayana</au><au>Ahmed, Abdurahman Mohammed</au><au>Yehualashet, Sisay Shewasinad</au><au>Dey, Sanjoy Kumer</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Time to recovery from necrotizing enterocolitis and its predictors among neonates admitted to Neonatal Intensive Care Unit in Bahir Dar, Ethiopia: A retrospective follow up study, 2022</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2024-10-22</date><risdate>2024</risdate><volume>19</volume><issue>10</issue><spage>e0311890</spage><pages>e0311890-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Necrotizing enterocolitis is one of the most common, life-threatening, gastrointestinal disorders in neonates. The recovery time for neonates with NEC varies depending on disease severity, prompt diagnosis, and effective treatment. Therefore, this study was intended to assess the time to recover from necrotizing enterocolitis and its' predictors among neonates admitted to Neonatal Intensive Care Unit in Bahir Dar City, Ethiopia.
An institution-based retrospective follow-up study design was employed. A sample of 361 medical records of neonates with necrotizing enterocolitis was selected using systematic random sampling. Diagnosis of NEC in this study required clinical, laboratory and radiographic findings. The survival function was described using Kaplan Meier survival curve and log-rank test. Bivariate and multivariate Cox-proportional hazard (Cox-PH) regression models were used for analysis.
The median recovery time from necrotizing enterocolitis for neonates in the neonatal intensive care unit was 12 days. The multivariable Cox-PH model showed that neonates classified as Stage III NEC (AHR: 0.42, 95% CI = 0.23-0.77) and those exposed to perinatal asphyxia (AHR: 0.51, 95% CI: 0.35-0.74) had a negative impact on NEC recovery time. However, neonates with a birth weight of 1500-2499gm (AHR: 1.65, 95% CI: 1.05-2.58) and a platelet count greater than 150,000 (AHR: 1.75, 95% CI: 1.24-2.48) had a positive effect on NEC recovery time.
The recovery time for neonates in the neonatal intensive care unit with necrotizing enterocolitis was longer. Comorbidities and advanced stage of NEC were associated with prolonged recovery time from NEC. However, neonates with better platelet count and birth weight greater than 1500mg had shorter recovery time from NEC.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>39436945</pmid><doi>10.1371/journal.pone.0311890</doi><tpages>e0311890</tpages><orcidid>https://orcid.org/0000-0003-0264-5227</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Apgar score Asphyxia Biology and Life Sciences Birth weight Bivariate analysis Care and treatment Comorbidity Developing countries Diagnosis Enteral nutrition Enterocolitis Enterocolitis, Necrotizing - epidemiology Enterocolitis, Neonatal necrotizing Enterocolitis, Pseudomembranous Ethiopia - epidemiology Female Follow-Up Studies Gastrointestinal diseases Gestational age Health aspects Hospitals Humans Infant, Newborn Infants (Newborn) Intensive Care Units, Neonatal LDCs Male Medical records Medicine and Health Sciences Necrotizing enterocolitis Neonates Patient outcomes Platelets Population Random sampling Rank tests Recovery time Regression analysis Regression models Retrospective Studies Risk factors Standard scores Statistical sampling Survival Thrombocytopenia Time Factors |
| title | Time to recovery from necrotizing enterocolitis and its predictors among neonates admitted to Neonatal Intensive Care Unit in Bahir Dar, Ethiopia: A retrospective follow up study, 2022 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T03%3A53%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Time%20to%20recovery%20from%20necrotizing%20enterocolitis%20and%20its%20predictors%20among%20neonates%20admitted%20to%20Neonatal%20Intensive%20Care%20Unit%20in%20Bahir%20Dar,%20Ethiopia:%20A%20retrospective%20follow%20up%20study,%202022&rft.jtitle=PloS%20one&rft.au=Tefera,%20Birtukan%20Ayana&rft.date=2024-10-22&rft.volume=19&rft.issue=10&rft.spage=e0311890&rft.pages=e0311890-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0311890&rft_dat=%3Cgale_plos_%3EA813222202%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3119603129&rft_id=info:pmid/39436945&rft_galeid=A813222202&rfr_iscdi=true |