Periodontitis and pre-eclampsia among pregnant women in Rwanda: A case-control study
Several studies have indicated that the presence of periodontitis during pregnancy could increase the risk of developing pre-eclampsia, thereby negatively influencing pregnancy outcomes for both the mother and child. Notably, despite the high prevalence of both periodontitis and adverse pregnancy ou...
Gespeichert in:
| Veröffentlicht in: | PloS one 2024-10, Vol.19 (10), p.e0312103 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 10 |
| container_start_page | e0312103 |
| container_title | PloS one |
| container_volume | 19 |
| creator | Gatarayiha, Agnes Ntaganira, Joseph Brookes, Zoe Mutesa, Léon Gustafsson, Anders Rulisa, Stephen |
| description | Several studies have indicated that the presence of periodontitis during pregnancy could increase the risk of developing pre-eclampsia, thereby negatively influencing pregnancy outcomes for both the mother and child. Notably, despite the high prevalence of both periodontitis and adverse pregnancy outcomes in Rwanda, there exists a crucial evidence gap concerning the precise relationship between periodontitis and pre-eclampsia.
The aim of this study was to assess the association between periodontitis and pre-eclampsia amongst pregnant women in Rwanda.
Employing an unmatched 1:2 case-control design, we studied 52 pre-eclamptic and 104 non-pre-eclamptic pregnant women aged ≥18 years at two referral hospitals in Rwanda. Pre-eclampsia was defined as a systolic blood pressure ≥ 140 and diastolic blood pressure ≥ 90 mm Hg, diagnosed after 20 weeks of gestation and proteinuria of ≥300mL in 24 hours of urine collection. Periodontitis was defined as the presence of two or more teeth with one or more sites with a pocket depth ≥ 4mm and clinical attachment loss >3 mm at the same site, assessed through clinical attachment loss measurement. Bivariate analysis and logistic regression were used to estimate Odds ratio (ORs) and 95% confidence interval.
The prevalence of periodontitis was significantly higher among women with pre-eclampsia, compared to pregnant women without pre-eclampsia, at 90.4% and 55.8%, respectively (p< 0.001). Pregnant Women with periodontitis were 3.85 times more likely to develop pre-eclampsia after controlling for relevant confounders (adjusted Odds Ratio [aOR] = 3.85, 95%CI = 1.14-12.97, p |
| doi_str_mv | 10.1371/journal.pone.0312103 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_3116587966</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A812225537</galeid><sourcerecordid>A812225537</sourcerecordid><originalsourceid>FETCH-LOGICAL-c476t-511a68157c3dc789d6cc62ee512454165ba799c8102166006bd4a37bc636969c3</originalsourceid><addsrcrecordid>eNptkl2L1DAUhoso7of-A9GCsHjTMSdpktYbGRa_YEGR9Tqk6ZmZrGnSbVqH_fdmnO4yI0sucjh53jc5JyfLXgFZAJPw_iZMg9du0QePC8KAAmFPslOoGS0EJezpQXySncV4QwhnlRDPsxNWlwQoI6fZ9Q8cbGiDH-1oY659m_cDFmic7vpoda674Ne73NprP-bb0KHPrc9_bhOrP-TL3OiIhUkOQ3B5HKf27kX2bKVdxJfzfp79-vzp-vJrcfX9y7fL5VVhSinGggNoUQGXhrVGVnUrjBEUkQMteQmCN1rWtamAUBCCENG0pWayMYKJWtSGnWdv9r69C1HNDYmKQdJWshYiEcWeiFvsp0b1g-30cKeCtmpO_U4RqqqSlEPiP86OU9NhazBVpd2R7PjE241ahz8KoJS0ZiQ5vJsdhnA7YRxVZ6NB57THMO0fJyQX_y57-x_6eAkztdYOlfWrkC42O1O1rIBSyjmTiVo8QqXVYmfT5-DKpvyR4OJAsEHtxk0Mbhpt8PEYLPegGUKMA64eugFE7Sbx_tVqN4lqnsQke33YyQfR_eixvx7c2YU</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3116587966</pqid></control><display><type>article</type><title>Periodontitis and pre-eclampsia among pregnant women in Rwanda: A case-control study</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>SWEPUB Freely available online</source><source>Free Full-Text Journals in Chemistry</source><source>Public Library of Science (PLoS)</source><creator>Gatarayiha, Agnes ; Ntaganira, Joseph ; Brookes, Zoe ; Mutesa, Léon ; Gustafsson, Anders ; Rulisa, Stephen</creator><creatorcontrib>Gatarayiha, Agnes ; Ntaganira, Joseph ; Brookes, Zoe ; Mutesa, Léon ; Gustafsson, Anders ; Rulisa, Stephen</creatorcontrib><description>Several studies have indicated that the presence of periodontitis during pregnancy could increase the risk of developing pre-eclampsia, thereby negatively influencing pregnancy outcomes for both the mother and child. Notably, despite the high prevalence of both periodontitis and adverse pregnancy outcomes in Rwanda, there exists a crucial evidence gap concerning the precise relationship between periodontitis and pre-eclampsia.
The aim of this study was to assess the association between periodontitis and pre-eclampsia amongst pregnant women in Rwanda.
Employing an unmatched 1:2 case-control design, we studied 52 pre-eclamptic and 104 non-pre-eclamptic pregnant women aged ≥18 years at two referral hospitals in Rwanda. Pre-eclampsia was defined as a systolic blood pressure ≥ 140 and diastolic blood pressure ≥ 90 mm Hg, diagnosed after 20 weeks of gestation and proteinuria of ≥300mL in 24 hours of urine collection. Periodontitis was defined as the presence of two or more teeth with one or more sites with a pocket depth ≥ 4mm and clinical attachment loss >3 mm at the same site, assessed through clinical attachment loss measurement. Bivariate analysis and logistic regression were used to estimate Odds ratio (ORs) and 95% confidence interval.
The prevalence of periodontitis was significantly higher among women with pre-eclampsia, compared to pregnant women without pre-eclampsia, at 90.4% and 55.8%, respectively (p< 0.001). Pregnant Women with periodontitis were 3.85 times more likely to develop pre-eclampsia after controlling for relevant confounders (adjusted Odds Ratio [aOR] = 3.85, 95%CI = 1.14-12.97, p<0.05).
This study results indicates that periodontitis is significantly associated with pre-eclampsia among pregnant women in Rwanda. These findings suggest that future research should explore whether enhancing periodontal health during pregnancy could contribute to reducing pre-eclampsia in this specific population.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0312103</identifier><identifier>PMID: 39401230</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Antibiotics ; Attachment ; Bivariate analysis ; Blood pressure ; Care and treatment ; Case-Control Studies ; Confidence intervals ; Data collection ; Diagnosis ; Disease susceptibility ; Female ; Gum disease ; Gynecology ; Health aspects ; Health care ; Hospitals ; Humans ; Hypertension ; Inflammation ; Maternal mortality ; Medicine and Health Sciences ; Obstetrics ; Orthodontics ; Pathogenesis ; Periodontitis ; Periodontitis - complications ; Periodontitis - epidemiology ; Population studies ; Pre-eclampsia ; Pre-Eclampsia - epidemiology ; Preeclampsia ; Pregnancy ; Pregnancy complications ; Pregnant women ; Prevalence ; Proteins ; Proteinuria ; Risk Factors ; Rwanda - epidemiology ; Statistical analysis ; Tumor necrosis factor-TNF ; Urine ; Womens health ; Young Adult</subject><ispartof>PloS one, 2024-10, Vol.19 (10), p.e0312103</ispartof><rights>Copyright: © 2024 Gatarayiha et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2024 Public Library of Science</rights><rights>2024 Gatarayiha et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 Gatarayiha et al 2024 Gatarayiha et al</rights><rights>2024 Gatarayiha et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c476t-511a68157c3dc789d6cc62ee512454165ba799c8102166006bd4a37bc636969c3</cites><orcidid>0000-0002-6123-1879</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11472930/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11472930/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,723,776,780,860,881,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39401230$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:159805803$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Gatarayiha, Agnes</creatorcontrib><creatorcontrib>Ntaganira, Joseph</creatorcontrib><creatorcontrib>Brookes, Zoe</creatorcontrib><creatorcontrib>Mutesa, Léon</creatorcontrib><creatorcontrib>Gustafsson, Anders</creatorcontrib><creatorcontrib>Rulisa, Stephen</creatorcontrib><title>Periodontitis and pre-eclampsia among pregnant women in Rwanda: A case-control study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Several studies have indicated that the presence of periodontitis during pregnancy could increase the risk of developing pre-eclampsia, thereby negatively influencing pregnancy outcomes for both the mother and child. Notably, despite the high prevalence of both periodontitis and adverse pregnancy outcomes in Rwanda, there exists a crucial evidence gap concerning the precise relationship between periodontitis and pre-eclampsia.
The aim of this study was to assess the association between periodontitis and pre-eclampsia amongst pregnant women in Rwanda.
Employing an unmatched 1:2 case-control design, we studied 52 pre-eclamptic and 104 non-pre-eclamptic pregnant women aged ≥18 years at two referral hospitals in Rwanda. Pre-eclampsia was defined as a systolic blood pressure ≥ 140 and diastolic blood pressure ≥ 90 mm Hg, diagnosed after 20 weeks of gestation and proteinuria of ≥300mL in 24 hours of urine collection. Periodontitis was defined as the presence of two or more teeth with one or more sites with a pocket depth ≥ 4mm and clinical attachment loss >3 mm at the same site, assessed through clinical attachment loss measurement. Bivariate analysis and logistic regression were used to estimate Odds ratio (ORs) and 95% confidence interval.
The prevalence of periodontitis was significantly higher among women with pre-eclampsia, compared to pregnant women without pre-eclampsia, at 90.4% and 55.8%, respectively (p< 0.001). Pregnant Women with periodontitis were 3.85 times more likely to develop pre-eclampsia after controlling for relevant confounders (adjusted Odds Ratio [aOR] = 3.85, 95%CI = 1.14-12.97, p<0.05).
This study results indicates that periodontitis is significantly associated with pre-eclampsia among pregnant women in Rwanda. These findings suggest that future research should explore whether enhancing periodontal health during pregnancy could contribute to reducing pre-eclampsia in this specific population.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Antibiotics</subject><subject>Attachment</subject><subject>Bivariate analysis</subject><subject>Blood pressure</subject><subject>Care and treatment</subject><subject>Case-Control Studies</subject><subject>Confidence intervals</subject><subject>Data collection</subject><subject>Diagnosis</subject><subject>Disease susceptibility</subject><subject>Female</subject><subject>Gum disease</subject><subject>Gynecology</subject><subject>Health aspects</subject><subject>Health care</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Inflammation</subject><subject>Maternal mortality</subject><subject>Medicine and Health Sciences</subject><subject>Obstetrics</subject><subject>Orthodontics</subject><subject>Pathogenesis</subject><subject>Periodontitis</subject><subject>Periodontitis - complications</subject><subject>Periodontitis - epidemiology</subject><subject>Population studies</subject><subject>Pre-eclampsia</subject><subject>Pre-Eclampsia - epidemiology</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Pregnancy complications</subject><subject>Pregnant women</subject><subject>Prevalence</subject><subject>Proteins</subject><subject>Proteinuria</subject><subject>Risk Factors</subject><subject>Rwanda - epidemiology</subject><subject>Statistical analysis</subject><subject>Tumor necrosis factor-TNF</subject><subject>Urine</subject><subject>Womens health</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>D8T</sourceid><recordid>eNptkl2L1DAUhoso7of-A9GCsHjTMSdpktYbGRa_YEGR9Tqk6ZmZrGnSbVqH_fdmnO4yI0sucjh53jc5JyfLXgFZAJPw_iZMg9du0QePC8KAAmFPslOoGS0EJezpQXySncV4QwhnlRDPsxNWlwQoI6fZ9Q8cbGiDH-1oY659m_cDFmic7vpoda674Ne73NprP-bb0KHPrc9_bhOrP-TL3OiIhUkOQ3B5HKf27kX2bKVdxJfzfp79-vzp-vJrcfX9y7fL5VVhSinGggNoUQGXhrVGVnUrjBEUkQMteQmCN1rWtamAUBCCENG0pWayMYKJWtSGnWdv9r69C1HNDYmKQdJWshYiEcWeiFvsp0b1g-30cKeCtmpO_U4RqqqSlEPiP86OU9NhazBVpd2R7PjE241ahz8KoJS0ZiQ5vJsdhnA7YRxVZ6NB57THMO0fJyQX_y57-x_6eAkztdYOlfWrkC42O1O1rIBSyjmTiVo8QqXVYmfT5-DKpvyR4OJAsEHtxk0Mbhpt8PEYLPegGUKMA64eugFE7Sbx_tVqN4lqnsQke33YyQfR_eixvx7c2YU</recordid><startdate>20241014</startdate><enddate>20241014</enddate><creator>Gatarayiha, Agnes</creator><creator>Ntaganira, Joseph</creator><creator>Brookes, Zoe</creator><creator>Mutesa, Léon</creator><creator>Gustafsson, Anders</creator><creator>Rulisa, Stephen</creator><general>Public Library of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0002-6123-1879</orcidid></search><sort><creationdate>20241014</creationdate><title>Periodontitis and pre-eclampsia among pregnant women in Rwanda: A case-control study</title><author>Gatarayiha, Agnes ; Ntaganira, Joseph ; Brookes, Zoe ; Mutesa, Léon ; Gustafsson, Anders ; Rulisa, Stephen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-511a68157c3dc789d6cc62ee512454165ba799c8102166006bd4a37bc636969c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Antibiotics</topic><topic>Attachment</topic><topic>Bivariate analysis</topic><topic>Blood pressure</topic><topic>Care and treatment</topic><topic>Case-Control Studies</topic><topic>Confidence intervals</topic><topic>Data collection</topic><topic>Diagnosis</topic><topic>Disease susceptibility</topic><topic>Female</topic><topic>Gum disease</topic><topic>Gynecology</topic><topic>Health aspects</topic><topic>Health care</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Inflammation</topic><topic>Maternal mortality</topic><topic>Medicine and Health Sciences</topic><topic>Obstetrics</topic><topic>Orthodontics</topic><topic>Pathogenesis</topic><topic>Periodontitis</topic><topic>Periodontitis - complications</topic><topic>Periodontitis - epidemiology</topic><topic>Population studies</topic><topic>Pre-eclampsia</topic><topic>Pre-Eclampsia - epidemiology</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>Pregnancy complications</topic><topic>Pregnant women</topic><topic>Prevalence</topic><topic>Proteins</topic><topic>Proteinuria</topic><topic>Risk Factors</topic><topic>Rwanda - epidemiology</topic><topic>Statistical analysis</topic><topic>Tumor necrosis factor-TNF</topic><topic>Urine</topic><topic>Womens health</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gatarayiha, Agnes</creatorcontrib><creatorcontrib>Ntaganira, Joseph</creatorcontrib><creatorcontrib>Brookes, Zoe</creatorcontrib><creatorcontrib>Mutesa, Léon</creatorcontrib><creatorcontrib>Gustafsson, Anders</creatorcontrib><creatorcontrib>Rulisa, Stephen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gatarayiha, Agnes</au><au>Ntaganira, Joseph</au><au>Brookes, Zoe</au><au>Mutesa, Léon</au><au>Gustafsson, Anders</au><au>Rulisa, Stephen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Periodontitis and pre-eclampsia among pregnant women in Rwanda: A case-control study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2024-10-14</date><risdate>2024</risdate><volume>19</volume><issue>10</issue><spage>e0312103</spage><pages>e0312103-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Several studies have indicated that the presence of periodontitis during pregnancy could increase the risk of developing pre-eclampsia, thereby negatively influencing pregnancy outcomes for both the mother and child. Notably, despite the high prevalence of both periodontitis and adverse pregnancy outcomes in Rwanda, there exists a crucial evidence gap concerning the precise relationship between periodontitis and pre-eclampsia.
The aim of this study was to assess the association between periodontitis and pre-eclampsia amongst pregnant women in Rwanda.
Employing an unmatched 1:2 case-control design, we studied 52 pre-eclamptic and 104 non-pre-eclamptic pregnant women aged ≥18 years at two referral hospitals in Rwanda. Pre-eclampsia was defined as a systolic blood pressure ≥ 140 and diastolic blood pressure ≥ 90 mm Hg, diagnosed after 20 weeks of gestation and proteinuria of ≥300mL in 24 hours of urine collection. Periodontitis was defined as the presence of two or more teeth with one or more sites with a pocket depth ≥ 4mm and clinical attachment loss >3 mm at the same site, assessed through clinical attachment loss measurement. Bivariate analysis and logistic regression were used to estimate Odds ratio (ORs) and 95% confidence interval.
The prevalence of periodontitis was significantly higher among women with pre-eclampsia, compared to pregnant women without pre-eclampsia, at 90.4% and 55.8%, respectively (p< 0.001). Pregnant Women with periodontitis were 3.85 times more likely to develop pre-eclampsia after controlling for relevant confounders (adjusted Odds Ratio [aOR] = 3.85, 95%CI = 1.14-12.97, p<0.05).
This study results indicates that periodontitis is significantly associated with pre-eclampsia among pregnant women in Rwanda. These findings suggest that future research should explore whether enhancing periodontal health during pregnancy could contribute to reducing pre-eclampsia in this specific population.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>39401230</pmid><doi>10.1371/journal.pone.0312103</doi><orcidid>https://orcid.org/0000-0002-6123-1879</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2024-10, Vol.19 (10), p.e0312103 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_3116587966 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; SWEPUB Freely available online; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adolescent Adult Antibiotics Attachment Bivariate analysis Blood pressure Care and treatment Case-Control Studies Confidence intervals Data collection Diagnosis Disease susceptibility Female Gum disease Gynecology Health aspects Health care Hospitals Humans Hypertension Inflammation Maternal mortality Medicine and Health Sciences Obstetrics Orthodontics Pathogenesis Periodontitis Periodontitis - complications Periodontitis - epidemiology Population studies Pre-eclampsia Pre-Eclampsia - epidemiology Preeclampsia Pregnancy Pregnancy complications Pregnant women Prevalence Proteins Proteinuria Risk Factors Rwanda - epidemiology Statistical analysis Tumor necrosis factor-TNF Urine Womens health Young Adult |
| title | Periodontitis and pre-eclampsia among pregnant women in Rwanda: A case-control study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-19T23%3A41%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Periodontitis%20and%20pre-eclampsia%20among%20pregnant%20women%20in%20Rwanda:%20A%20case-control%20study&rft.jtitle=PloS%20one&rft.au=Gatarayiha,%20Agnes&rft.date=2024-10-14&rft.volume=19&rft.issue=10&rft.spage=e0312103&rft.pages=e0312103-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0312103&rft_dat=%3Cgale_plos_%3EA812225537%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3116587966&rft_id=info:pmid/39401230&rft_galeid=A812225537&rfr_iscdi=true |