Preventive and treatment efficiency of dendrosomal nano-curcumin against ISO-induced cardiac fibrosis in mouse model

Cardiac fibrosis (c-fibrosis) is a critical factor in cardiovascular diseases, leading to impaired cardiac function and heart failure. This study aims to optimize the isoproterenol (ISO)-induced c-fibrosis model and evaluate the therapeutic efficacy of dendrosomal nano-curcumin (DNC) in both in-vitr...

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Veröffentlicht in:	PloS one 2024-10, Vol.19 (10), p.e0311817
Hauptverfasser:	Beikzadeh, Behnaz, Khani, Mona, Zarinehzadeh, Yasamin, Abedini Bakhshmand, Elham, Sadeghizadeh, Majid, Rabbani, Shahram, Soltani, Bahram M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal experimentation Animals Cardiac function Cardiovascular diseases Care and treatment Cartilage oligomeric matrix protein Cell cycle Chronic fatigue syndrome Chronic illnesses Collagen Collagen (type I) Congestive heart failure Coronary artery disease COVID-19 Curcumin Curcumin - pharmacology Dendrimers - chemistry Dendrimers - pharmacology Diagnosis Disease Models, Animal Drug dosages Evaluation Extracellular matrix Fibroblasts Fibroblasts - drug effects Fibroblasts - metabolism Fibrosis Flow cytometry Gene expression Growth factors Heart Heart diseases Isoproterenol Laboratory animals Lung diseases Lungs Male Medical treatment Mice Mice, Inbred C57BL Morphology Myocardium - metabolism Myocardium - pathology Nanoparticles - chemistry Polystyrene Polystyrene resins Properties Proteins Pulmonary fibrosis Signal transduction Tumor necrosis factor-TNF Turmeric
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