Single-cell transcriptomic atlas of enteroendocrine cells along the murine gastrointestinal tract

Enteroendocrine cells (EECs) produce over 20 gut hormones which contribute to intestinal physiology, nutrient metabolism and the regulation of food intake. The objective of this study was to generate a comprehensive transcriptomic map of mouse EECs from the stomach to the rectum. EECs were purified...

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Veröffentlicht in:	PloS one 2024-10, Vol.19 (10), p.e0308942
Hauptverfasser:	Smith, Christopher A, O'Flaherty, Elisabeth A A, Guccio, Nunzio, Punnoose, Austin, Darwish, Tamana, Lewis, Jo E, Foreman, Rachel E, Li, Joyce, Kay, Richard G, Adriaenssens, Alice E, Reimann, Frank, Gribble, Fiona M
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Beta2 protein Biology and Life Sciences Calcium Calcium imaging Care and treatment Cell activation Cholecystokinin Cholecystokinin - genetics Cholecystokinin - metabolism Clustering Computational biology Cytometry Diabetes Diagnosis Digestive system Enteroendocrine Cells - metabolism Fatty acids Females Flow cytometry Flow mapping Food intake G protein-coupled receptors Gastrointestinal diseases Gastrointestinal surgery Gastrointestinal system Gastrointestinal tract Gastrointestinal Tract - cytology Gastrointestinal Tract - metabolism Gene Expression Profiling Gene sequencing Genes Genomes Genomics Hormones Intestine Large intestine Male Medical research Medicine and Health Sciences Melanocortin Melanocortin MC4 receptors Mice Nutrients Peptides RNA sequencing Secretion Single-Cell Analysis Small intestine Stimuli Stomach Transcriptome Transcriptomes Transcriptomics
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