Cytotoxicity of bendamustine, alone and in combination with novel agents, toward adult T-cell leukemia cells

Adult T-cell leukemia/lymphoma (ATL) develops from the infection of T cells with human T lymphotropic virus type 1 (HTLV-1). There are an estimated 5-20 million HTLV-1 carriers worldwide and the patients are frequently observed in subtropical Africa, the Caribbean, Middle East, South America, and So...

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Veröffentlicht in:	PloS one 2024-09, Vol.19 (9), p.e0309533
Hauptverfasser:	Osada, Naoki, Kikuchi, Jiro, Okada, Yosuke, Matsuoka, Sae, Morishita, Kazuhiro, Nakasone, Hideki, Furukawa, Yusuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antibodies Antineoplastic Combined Chemotherapy Protocols - pharmacology Antineoplastic Combined Chemotherapy Protocols - therapeutic use Antineoplastic drugs Apoptosis - drug effects Bcl-2 protein Bendamustine Bendamustine Hydrochloride - pharmacology Bendamustine Hydrochloride - therapeutic use Biology and Life Sciences Care and treatment Cell growth Cell Line, Tumor Chemotherapy Clinical trials Complications and side effects Cytotoxicity Diagnosis Disease resistance DNA damage Effectiveness Histone deacetylase Histone Deacetylase Inhibitors - pharmacology Histone Deacetylase Inhibitors - therapeutic use Humans Inhibitors Laboratory animals Leukemia Leukemia-Lymphoma, Adult T-Cell - drug therapy Leukemia-Lymphoma, Adult T-Cell - pathology Lymphocytes Lymphocytes B Lymphocytes T Lymphoma Medical prognosis Medicine and Health Sciences Mice Multiple myeloma Patient outcomes Patients People and Places Peripheral neuropathy Physical Sciences Quality of life Research and Analysis Methods Side effects T cell lymphoma Toxicity Tumors Xenograft Model Antitumor Assays
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