Arctigenin inhibits the progression of colorectal cancer through epithelial-mesenchymal transition via PI3K/Akt/mTOR signaling pathway

Colorectal cancer (CRC) is a significant disease worldwide, with high mortality rates. Conventional treatment methods often lead to metastasis and drug resistance, highlighting the need to explore new drugs and their potential molecular mechanisms. In this study, we investigated the effects of arcti...

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Veröffentlicht in:	PloS one 2024-09, Vol.19 (9), p.e0308947
Hauptverfasser:	Chen, Xiang-Fan, Liu, Pei-Gen, Sheng, Nan, Li, Xin-Shuai, Hu, Rui-Kun, Zhu, Long-Xun, Feng, Panfeng
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Allografts Animals Antibodies Apoptosis Apoptosis - drug effects BAX protein Bcl-2 protein Cancer Cancer therapies Care and treatment Caspase-3 Cell culture Cell cycle Cell Line, Tumor Cell migration Cell Movement - drug effects Cell proliferation Cell Proliferation - drug effects Cellular signal transduction Chemotherapy Cholecystokinin Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - drug therapy Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Cyclin-dependent kinases Diagnosis Disease Progression Disease resistance Drug resistance E-cadherin Epithelial cells Epithelial-Mesenchymal Transition - drug effects Flow cytometry Furans - pharmacology Gelatinase A Gelatinase B Health aspects Humans Immunoblotting Immunofluorescence Immunosuppressive agents In vivo methods and tests Kinases Laboratory animals Lignans - pharmacology Liver cancer Male Materia medica, Vegetable Metastases Metastasis Mice Mice, Inbred BALB C Mice, Nude Molecular modelling Mortality Phosphatidylinositol 3-Kinases - metabolism Physiology Plant extracts Proto-Oncogene Proteins c-akt - metabolism Radiation Side effects Signal transduction Signal Transduction - drug effects Stem cells TOR Serine-Threonine Kinases - metabolism Tumors Xenograft Model Antitumor Assays
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