PPARγ agonist alleviates calcium oxalate nephrolithiasis by regulating mitochondrial dynamics in renal tubular epithelial cell

Kidney stone formation is a common disease that causes a significant threat to human health. The crystallization mechanism of calcium oxalate, the most common type of kidney stone, has been extensively researched, yet the damaging effects and mechanisms of calcium oxalate crystals on renal tubular e...

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Veröffentlicht in:	PloS one 2024-09, Vol.19 (9), p.e0310947
Hauptverfasser:	Liu, Junfa, Liu, Xingyang, Guo, Lizhe, Liu, Xiongfei, Gao, Qian, Wang, E, Dong, Zhitao
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Animal models Animals Apoptosis Apoptosis - drug effects Bioaccumulation Biology and Life Sciences Calcium Calcium (blood) Calcium (mitochondrial) Calcium oxalate Calcium Oxalate - metabolism Calcium signalling Calculi Cell culture Cell Line Critical components Crystallization Crystals Disease Disease Models, Animal Drinking water Dynamics Epithelial cells Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelial Cells - pathology Epithelium Ethylene glycol Fibrosis Fission Gene expression Homeostasis Humans In vivo methods and tests Inflammation Injury analysis Kidney stones Kidney Tubules - drug effects Kidney Tubules - metabolism Kidney Tubules - pathology Kidneys Laboratory animals Lithiasis Male Medicine and Health Sciences Mitochondria Mitochondria - drug effects Mitochondria - metabolism Mitochondrial DNA Mitochondrial Dynamics - drug effects Nephrolithiasis Nephrolithiasis - drug therapy Nephrolithiasis - metabolism Nephrolithiasis - pathology Oxalic acid Oxidative stress Oxidative Stress - drug effects Peroxisome proliferator-activated receptors Physical Sciences PPAR gamma - agonists PPAR gamma - metabolism Quality control Rats Rats, Sprague-Dawley Reactive oxygen species Renal function Research and Analysis Methods Ribonucleic acid RNA
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