Advanced HIV disease and its predictors among newly diagnosed PLHIV in the Gedeo zone, southern Ethiopia
Globally, HIV infection remains a leading cause of morbidity and mortality. Despite reducing new infections, the global response to advanced HIV disease (AHD) remains ineffective, leaving HIV epidemics a significant public health threat worldwide. In Ethiopia, evidence regarding AHD is scarce. There...
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| creator | Lerango, Temesgen Leka Markos, Tesfalidet Yehualeshet, Daniel Kefyalew, Endashaw Lerango, Semalgn Leka |
| description | Globally, HIV infection remains a leading cause of morbidity and mortality. Despite reducing new infections, the global response to advanced HIV disease (AHD) remains ineffective, leaving HIV epidemics a significant public health threat worldwide. In Ethiopia, evidence regarding AHD is scarce. Therefore, this study aimed to assess the prevalence and predictors of AHD among newly diagnosed people living with HIV (PLHIV) initiating antiretroviral therapy in the Gedeo zone, southern Ethiopia.
A facility-based cross-sectional study was conducted from May 29, 2023, to February 06, 2024, at health facilities providing HIV care in the Gedeo zone, southern Ethiopia. A total of 427 PLHIV-initiating antiretroviral therapy (ART) were recruited for the study. The data were collected through face-to-face interviews and record reviews using KoboCollect version 2.4 and analyzed using R version 4.3.3. The Akaike information criterion (AIC) model selection was used to evaluate and choose the best-fitting model to describe the relationship between AHD and predictors. Finally, variables with a p-value less than 0.05 were considered independent predictors in the multivariable regression analysis.
The study participants' mean (±SD) age was 31.3 (±8.7) years. The overall prevalence of AHD among newly diagnosed PLHIV-initiating ART was 34.4% (95% CI: 29.8%, 39.1%). Rural residence (AOR = 3.48, 95% CI: 2.24, 5.47), alcohol consumption (AOR = 2.48, 95% CI: 1.59, 3.90), and being identified through community-based index case testing (ICT) (AOR = 0.26, 95% CI: 0.13, 0.51) were found to be independent predictors of AHD.
The prevalence of AHD among newly diagnosed individuals initiating ART was high. PLHIV who consume alcohol should receive detailed counseling on how it can negatively impact their progress with antiretroviral treatment. HIV testing should be enhanced in rural communities by strengthening community health campaigns. Furthermore, community-based index case testing should be strengthened for early identification of PLHIV. |
| doi_str_mv | 10.1371/journal.pone.0310373 |
| format | Article |
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A facility-based cross-sectional study was conducted from May 29, 2023, to February 06, 2024, at health facilities providing HIV care in the Gedeo zone, southern Ethiopia. A total of 427 PLHIV-initiating antiretroviral therapy (ART) were recruited for the study. The data were collected through face-to-face interviews and record reviews using KoboCollect version 2.4 and analyzed using R version 4.3.3. The Akaike information criterion (AIC) model selection was used to evaluate and choose the best-fitting model to describe the relationship between AHD and predictors. Finally, variables with a p-value less than 0.05 were considered independent predictors in the multivariable regression analysis.
The study participants' mean (±SD) age was 31.3 (±8.7) years. The overall prevalence of AHD among newly diagnosed PLHIV-initiating ART was 34.4% (95% CI: 29.8%, 39.1%). Rural residence (AOR = 3.48, 95% CI: 2.24, 5.47), alcohol consumption (AOR = 2.48, 95% CI: 1.59, 3.90), and being identified through community-based index case testing (ICT) (AOR = 0.26, 95% CI: 0.13, 0.51) were found to be independent predictors of AHD.
The prevalence of AHD among newly diagnosed individuals initiating ART was high. PLHIV who consume alcohol should receive detailed counseling on how it can negatively impact their progress with antiretroviral treatment. HIV testing should be enhanced in rural communities by strengthening community health campaigns. Furthermore, community-based index case testing should be strengthened for early identification of PLHIV.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0310373</identifier><identifier>PMID: 39269935</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acquired immune deficiency syndrome ; Adult ; AIDS ; Anti-HIV Agents - therapeutic use ; Antiretroviral agents ; Antiretroviral drugs ; Antiretroviral therapy ; Care and treatment ; Cross-Sectional Studies ; Disease prevention ; Drug therapy ; Epidemics ; Ethiopia - epidemiology ; Female ; Health care facilities ; Health facilities ; Health promotion ; Health risks ; HIV ; HIV (Viruses) ; HIV Infections - diagnosis ; HIV Infections - drug therapy ; HIV Infections - epidemiology ; Hospitals ; Human immunodeficiency virus ; Humans ; Independent variables ; Infections ; Male ; Medical care ; Medical diagnosis ; Middle Aged ; Morbidity ; Patient outcomes ; Personal health ; Prevalence ; Public health ; Quality management ; Regression analysis ; Risk Factors ; Rural areas ; Rural communities ; Variables ; Young Adult</subject><ispartof>PloS one, 2024-09, Vol.19 (9), p.e0310373</ispartof><rights>Copyright: © 2024 Lerango et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2024 Public Library of Science</rights><rights>2024 Lerango et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 Lerango et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c450t-5c59a3d2164d810256600872ae20cab2c00f9b43553f268bcea0161b1c3d1d1c3</cites><orcidid>0000-0002-9016-5284 ; 0000-0002-9375-0219</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0310373&type=printable$$EPDF$$P50$$Gplos$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0310373$$EHTML$$P50$$Gplos$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,864,2926,23865,27923,27924,79371,79372</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39269935$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>McCreesh, Nicky</contributor><creatorcontrib>Lerango, Temesgen Leka</creatorcontrib><creatorcontrib>Markos, Tesfalidet</creatorcontrib><creatorcontrib>Yehualeshet, Daniel</creatorcontrib><creatorcontrib>Kefyalew, Endashaw</creatorcontrib><creatorcontrib>Lerango, Semalgn Leka</creatorcontrib><title>Advanced HIV disease and its predictors among newly diagnosed PLHIV in the Gedeo zone, southern Ethiopia</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Globally, HIV infection remains a leading cause of morbidity and mortality. Despite reducing new infections, the global response to advanced HIV disease (AHD) remains ineffective, leaving HIV epidemics a significant public health threat worldwide. In Ethiopia, evidence regarding AHD is scarce. Therefore, this study aimed to assess the prevalence and predictors of AHD among newly diagnosed people living with HIV (PLHIV) initiating antiretroviral therapy in the Gedeo zone, southern Ethiopia.
A facility-based cross-sectional study was conducted from May 29, 2023, to February 06, 2024, at health facilities providing HIV care in the Gedeo zone, southern Ethiopia. A total of 427 PLHIV-initiating antiretroviral therapy (ART) were recruited for the study. The data were collected through face-to-face interviews and record reviews using KoboCollect version 2.4 and analyzed using R version 4.3.3. The Akaike information criterion (AIC) model selection was used to evaluate and choose the best-fitting model to describe the relationship between AHD and predictors. Finally, variables with a p-value less than 0.05 were considered independent predictors in the multivariable regression analysis.
The study participants' mean (±SD) age was 31.3 (±8.7) years. The overall prevalence of AHD among newly diagnosed PLHIV-initiating ART was 34.4% (95% CI: 29.8%, 39.1%). Rural residence (AOR = 3.48, 95% CI: 2.24, 5.47), alcohol consumption (AOR = 2.48, 95% CI: 1.59, 3.90), and being identified through community-based index case testing (ICT) (AOR = 0.26, 95% CI: 0.13, 0.51) were found to be independent predictors of AHD.
The prevalence of AHD among newly diagnosed individuals initiating ART was high. PLHIV who consume alcohol should receive detailed counseling on how it can negatively impact their progress with antiretroviral treatment. HIV testing should be enhanced in rural communities by strengthening community health campaigns. Furthermore, community-based index case testing should be strengthened for early identification of PLHIV.</description><subject>Acquired immune deficiency syndrome</subject><subject>Adult</subject><subject>AIDS</subject><subject>Anti-HIV Agents - therapeutic use</subject><subject>Antiretroviral agents</subject><subject>Antiretroviral drugs</subject><subject>Antiretroviral therapy</subject><subject>Care and treatment</subject><subject>Cross-Sectional Studies</subject><subject>Disease prevention</subject><subject>Drug therapy</subject><subject>Epidemics</subject><subject>Ethiopia - epidemiology</subject><subject>Female</subject><subject>Health care facilities</subject><subject>Health facilities</subject><subject>Health promotion</subject><subject>Health risks</subject><subject>HIV</subject><subject>HIV (Viruses)</subject><subject>HIV Infections - diagnosis</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - epidemiology</subject><subject>Hospitals</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Independent variables</subject><subject>Infections</subject><subject>Male</subject><subject>Medical care</subject><subject>Medical diagnosis</subject><subject>Middle Aged</subject><subject>Morbidity</subject><subject>Patient outcomes</subject><subject>Personal health</subject><subject>Prevalence</subject><subject>Public health</subject><subject>Quality management</subject><subject>Regression analysis</subject><subject>Risk Factors</subject><subject>Rural areas</subject><subject>Rural communities</subject><subject>Variables</subject><subject>Young 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HIV disease and its predictors among newly diagnosed PLHIV in the Gedeo zone, southern Ethiopia</title><author>Lerango, Temesgen Leka ; Markos, Tesfalidet ; Yehualeshet, Daniel ; Kefyalew, Endashaw ; Lerango, Semalgn Leka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-5c59a3d2164d810256600872ae20cab2c00f9b43553f268bcea0161b1c3d1d1c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>Adult</topic><topic>AIDS</topic><topic>Anti-HIV Agents - therapeutic use</topic><topic>Antiretroviral agents</topic><topic>Antiretroviral drugs</topic><topic>Antiretroviral therapy</topic><topic>Care and treatment</topic><topic>Cross-Sectional Studies</topic><topic>Disease prevention</topic><topic>Drug therapy</topic><topic>Epidemics</topic><topic>Ethiopia - epidemiology</topic><topic>Female</topic><topic>Health care 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Daniel</au><au>Kefyalew, Endashaw</au><au>Lerango, Semalgn Leka</au><au>McCreesh, Nicky</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Advanced HIV disease and its predictors among newly diagnosed PLHIV in the Gedeo zone, southern Ethiopia</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2024-09-13</date><risdate>2024</risdate><volume>19</volume><issue>9</issue><spage>e0310373</spage><pages>e0310373-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Globally, HIV infection remains a leading cause of morbidity and mortality. Despite reducing new infections, the global response to advanced HIV disease (AHD) remains ineffective, leaving HIV epidemics a significant public health threat worldwide. In Ethiopia, evidence regarding AHD is scarce. Therefore, this study aimed to assess the prevalence and predictors of AHD among newly diagnosed people living with HIV (PLHIV) initiating antiretroviral therapy in the Gedeo zone, southern Ethiopia.
A facility-based cross-sectional study was conducted from May 29, 2023, to February 06, 2024, at health facilities providing HIV care in the Gedeo zone, southern Ethiopia. A total of 427 PLHIV-initiating antiretroviral therapy (ART) were recruited for the study. The data were collected through face-to-face interviews and record reviews using KoboCollect version 2.4 and analyzed using R version 4.3.3. The Akaike information criterion (AIC) model selection was used to evaluate and choose the best-fitting model to describe the relationship between AHD and predictors. Finally, variables with a p-value less than 0.05 were considered independent predictors in the multivariable regression analysis.
The study participants' mean (±SD) age was 31.3 (±8.7) years. The overall prevalence of AHD among newly diagnosed PLHIV-initiating ART was 34.4% (95% CI: 29.8%, 39.1%). Rural residence (AOR = 3.48, 95% CI: 2.24, 5.47), alcohol consumption (AOR = 2.48, 95% CI: 1.59, 3.90), and being identified through community-based index case testing (ICT) (AOR = 0.26, 95% CI: 0.13, 0.51) were found to be independent predictors of AHD.
The prevalence of AHD among newly diagnosed individuals initiating ART was high. PLHIV who consume alcohol should receive detailed counseling on how it can negatively impact their progress with antiretroviral treatment. HIV testing should be enhanced in rural communities by strengthening community health campaigns. Furthermore, community-based index case testing should be strengthened for early identification of PLHIV.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>39269935</pmid><doi>10.1371/journal.pone.0310373</doi><tpages>e0310373</tpages><orcidid>https://orcid.org/0000-0002-9016-5284</orcidid><orcidid>https://orcid.org/0000-0002-9375-0219</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | PloS one, 2024-09, Vol.19 (9), p.e0310373 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Acquired immune deficiency syndrome Adult AIDS Anti-HIV Agents - therapeutic use Antiretroviral agents Antiretroviral drugs Antiretroviral therapy Care and treatment Cross-Sectional Studies Disease prevention Drug therapy Epidemics Ethiopia - epidemiology Female Health care facilities Health facilities Health promotion Health risks HIV HIV (Viruses) HIV Infections - diagnosis HIV Infections - drug therapy HIV Infections - epidemiology Hospitals Human immunodeficiency virus Humans Independent variables Infections Male Medical care Medical diagnosis Middle Aged Morbidity Patient outcomes Personal health Prevalence Public health Quality management Regression analysis Risk Factors Rural areas Rural communities Variables Young Adult |
| title | Advanced HIV disease and its predictors among newly diagnosed PLHIV in the Gedeo zone, southern Ethiopia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T13%3A49%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Advanced%20HIV%20disease%20and%20its%20predictors%20among%20newly%20diagnosed%20PLHIV%20in%20the%20Gedeo%20zone,%20southern%20Ethiopia&rft.jtitle=PloS%20one&rft.au=Lerango,%20Temesgen%20Leka&rft.date=2024-09-13&rft.volume=19&rft.issue=9&rft.spage=e0310373&rft.pages=e0310373-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0310373&rft_dat=%3Cgale_plos_%3EA808610436%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3104450033&rft_id=info:pmid/39269935&rft_galeid=A808610436&rfr_iscdi=true |