Associations between corticosteroid dosage and clinical outcomes in patients with hypoxemic COVID-19 pneumonia: A retrospective cohort study

Corticosteroids are commonly used to treat COVID-19 patients with hypoxemia, and clinicians have adjusted the corticosteroid intensity on the basis of clinical needs. However, neither the optimal dose nor the duration of treatment has been recommended. To investigate whether cumulative doses of cort...

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Veröffentlicht in:	PloS one 2024-09, Vol.19 (9), p.e0308069
Hauptverfasser:	Teeratakulpisarn, Napassorn, Chiewroongroj, Supattra, Naorungroj, Thummaporn, Ratanarat, Ranistha
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Cortex Hormones - administration & dosage Adrenal Cortex Hormones - adverse effects Adrenal Cortex Hormones - therapeutic use Aged Aged, 80 and over Antiviral drugs Bacterial pneumonia Corticoids Corticosteroids COVID-19 COVID-19 - complications COVID-19 - mortality COVID-19 Drug Treatment Dexamethasone Dexamethasone - administration & dosage Dexamethasone - adverse effects Dexamethasone - therapeutic use Dosage Dosage and administration Dose-Response Relationship, Drug Drug therapy Equivalence Female Health aspects Hospital Mortality Hospitals Humans Hypoxemia Hypoxia Hypoxia - drug therapy Male Middle Aged Mortality Multivariate analysis Nosocomial infection Nosocomial infections Patients Pharmacology, Experimental Physiological aspects Pneumonia Quartiles Retrospective Studies Risk factors SARS-CoV-2 - isolation & purification Steroids Treatment Outcome Ventilators
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