Causal association of menstrual reproductive factors on the risk of osteoarthritis: A univariate and multivariate Mendelian randomization study

Several observational studies have revealed a potential relationship between menstrual reproductive factors (MRF) and osteoarthritis (OA). However, the precise causal relationship remains elusive. This study performed Mendelian randomization (MR) to provide deeper insights into this relationship. Ut...

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Veröffentlicht in:	PloS one 2024-08, Vol.19 (8), p.e0307958
Hauptverfasser:	Tan, Xinzhe, Mei, Yifang, Zhou, Yihao, Liao, Zhichao, Zhang, Pengqi, Liu, Yichang, Han, Yixiao, Wang, Dongyan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Arthritis Birth Births Body mass index Confidence intervals Contraceptives Demographic aspects Female Fertility Genome-wide association studies Genome-Wide Association Study Health aspects Heterogeneity Hormone replacement therapy Humans Menarche Menarche - genetics Mendelian Randomization Analysis Menopause Menstruation Middle Aged Observational studies Oral contraceptives Osteoarthritis Osteoarthritis - epidemiology Osteoarthritis - genetics Osteoarthritis, Knee - epidemiology Osteoarthritis, Knee - etiology Osteoarthritis, Knee - genetics Pleiotropy Polymorphism, Single Nucleotide Randomization Risk Factors Sensitivity analysis Sexual behavior Sexual intercourse Statistical analysis Statistical methods Variables
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