Studying the dynamics of the drug processing of pyrazinamide in Mycobacterium tuberculosis

Pyrazinamide (PZA) is a key drug in the treatment of Mycobacterium tuberculosis. Although not completely understood yet, the bactericidal mechanism of PZA starts with its diffusion into the cell and subsequent conversion into pyrazinoic acid (POA) after the hydrolysis of ammonia group. This leads to...

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Veröffentlicht in:	PloS one 2024-08, Vol.19 (8), p.e0309352
Hauptverfasser:	Requena, David, Supo-Escalante, Rydberg R, Sheen, Patricia, Zimic, Mirko
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Acidification Ammonia Antitubercular Agents - pharmacology Bacteria Biology and Life Sciences Care and treatment Computer and Information Sciences Cytoplasm Differential equations Dosage and administration Drug resistance Enzymes Hydrogen-Ion Concentration Impact resistance Intracellular Kinetics Mathematical models Medicine and Health Sciences Metabolism Molecular dynamics Mutation Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - metabolism Nonlinear differential equations Patient outcomes pH effects Physical Sciences Physiological aspects Public health Pyrazinamide Pyrazinamide - analogs & derivatives Pyrazinamide - pharmacology Research and Analysis Methods Tuberculosis
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