The clinical significance of inflammatory biomarkers, IL6 cytokine, and systemic immune inflammatory index in rabbit model of acute and chronic Methicillin-resistant Staphylococcus epidermidis-induced osteomyelitis
Infections are a major complication of open fractures and fracture fixation. In this study, an innovative bioactive medical device was used to experimentally treat MRSE-induced osteomyelitis in rabbit tibia. This paper investigates the clinical significance of inflammatory biomarkers (NLR, PLR, MLR...
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| description | Infections are a major complication of open fractures and fracture fixation. In this study, an innovative bioactive medical device was used to experimentally treat MRSE-induced osteomyelitis in rabbit tibia. This paper investigates the clinical significance of inflammatory biomarkers (NLR, PLR, MLR and PMR), SII and IL-6 and assesses their role in the development of osteomyelitis. The main objective is to identify the utility of hematological reports derived from neutrophils, leukocytes, monocytes and platelets in the evolution of implant-related osteomyelitis and the estimation of treatment efficiency. In particular, this study compares the response of these inflammatory markers to different treatments in the presence or absence of bioactive materials and/or topical antibiotics over time. The analysis of the threads showed that NLR, PLR and SII had high values in the acute phase of the disease, so that after chronicization, they decrease. The animals treated with vancomycin nano-functionalized peptide-enriched silk fibroin-coated implants showed lower levels of inflammatory biomarkers compared to the other groups (empty implants and peptide-enriched silk fibroin-coated implants). NLR, PLR and SII, complemented by IL-6 can be used as fairly accurate biomarkers for the diagnosis of osteomyelitis. |
| doi_str_mv | 10.1371/journal.pone.0309145 |
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In this study, an innovative bioactive medical device was used to experimentally treat MRSE-induced osteomyelitis in rabbit tibia. This paper investigates the clinical significance of inflammatory biomarkers (NLR, PLR, MLR and PMR), SII and IL-6 and assesses their role in the development of osteomyelitis. The main objective is to identify the utility of hematological reports derived from neutrophils, leukocytes, monocytes and platelets in the evolution of implant-related osteomyelitis and the estimation of treatment efficiency. In particular, this study compares the response of these inflammatory markers to different treatments in the presence or absence of bioactive materials and/or topical antibiotics over time. The analysis of the threads showed that NLR, PLR and SII had high values in the acute phase of the disease, so that after chronicization, they decrease. The animals treated with vancomycin nano-functionalized peptide-enriched silk fibroin-coated implants showed lower levels of inflammatory biomarkers compared to the other groups (empty implants and peptide-enriched silk fibroin-coated implants). NLR, PLR and SII, complemented by IL-6 can be used as fairly accurate biomarkers for the diagnosis of osteomyelitis.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0309145</identifier><identifier>PMID: 39208074</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acute Disease ; Animals ; Anti-Bacterial Agents - pharmacology ; Antibiotics ; Bacterial infections ; Biocompatibility ; Biological activity ; Biological markers ; Biology and Life Sciences ; Biomarkers ; Biomarkers - blood ; Biomedical materials ; Blood platelets ; Bone implants ; Chronic Disease ; Clinical Relevance ; Cytokines ; Diagnosis ; Disease Models, Animal ; Drug resistance ; Drug resistance in microorganisms ; Engineering and Technology ; Ethylenediaminetetraacetic acid ; Evaluation ; Fractures ; Health aspects ; Hematology ; Immune system ; Infections ; Inflammation ; Interleukin 6 ; Interleukin-6 - blood ; Interleukin-6 - metabolism ; Internal fixation in fractures ; Laboratory animals ; Leukocytes (neutrophilic) ; Lymphocytes ; Males ; Medical equipment ; Medical innovations ; Medical research ; Medicine and Health Sciences ; Methicillin ; Monocytes ; Neutrophils ; Osteomyelitis ; Osteomyelitis - drug therapy ; Osteomyelitis - immunology ; Osteomyelitis - microbiology ; Pathogens ; Patients ; Peptides ; Physiological apparatus ; Physiological aspects ; Rabbits ; Research and Analysis Methods ; Silk ; Silk fibroin ; Staphylococcal Infections - drug therapy ; Staphylococcal Infections - immunology ; Staphylococcal Infections - microbiology ; Staphylococcus ; Staphylococcus epidermidis ; Surgical implants ; Tibia ; Titanium ; Transplants & implants ; Vancomycin ; Vancomycin - pharmacology ; Viral infections</subject><ispartof>PloS one, 2024-08, Vol.19 (8), p.e0309145</ispartof><rights>Copyright: © 2024 Ancuța et al. 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This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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In this study, an innovative bioactive medical device was used to experimentally treat MRSE-induced osteomyelitis in rabbit tibia. This paper investigates the clinical significance of inflammatory biomarkers (NLR, PLR, MLR and PMR), SII and IL-6 and assesses their role in the development of osteomyelitis. The main objective is to identify the utility of hematological reports derived from neutrophils, leukocytes, monocytes and platelets in the evolution of implant-related osteomyelitis and the estimation of treatment efficiency. In particular, this study compares the response of these inflammatory markers to different treatments in the presence or absence of bioactive materials and/or topical antibiotics over time. The analysis of the threads showed that NLR, PLR and SII had high values in the acute phase of the disease, so that after chronicization, they decrease. The animals treated with vancomycin nano-functionalized peptide-enriched silk fibroin-coated implants showed lower levels of inflammatory biomarkers compared to the other groups (empty implants and peptide-enriched silk fibroin-coated implants). 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In this study, an innovative bioactive medical device was used to experimentally treat MRSE-induced osteomyelitis in rabbit tibia. This paper investigates the clinical significance of inflammatory biomarkers (NLR, PLR, MLR and PMR), SII and IL-6 and assesses their role in the development of osteomyelitis. The main objective is to identify the utility of hematological reports derived from neutrophils, leukocytes, monocytes and platelets in the evolution of implant-related osteomyelitis and the estimation of treatment efficiency. In particular, this study compares the response of these inflammatory markers to different treatments in the presence or absence of bioactive materials and/or topical antibiotics over time. The analysis of the threads showed that NLR, PLR and SII had high values in the acute phase of the disease, so that after chronicization, they decrease. 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| recordid | cdi_plos_journals_3098716491 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Acute Disease Animals Anti-Bacterial Agents - pharmacology Antibiotics Bacterial infections Biocompatibility Biological activity Biological markers Biology and Life Sciences Biomarkers Biomarkers - blood Biomedical materials Blood platelets Bone implants Chronic Disease Clinical Relevance Cytokines Diagnosis Disease Models, Animal Drug resistance Drug resistance in microorganisms Engineering and Technology Ethylenediaminetetraacetic acid Evaluation Fractures Health aspects Hematology Immune system Infections Inflammation Interleukin 6 Interleukin-6 - blood Interleukin-6 - metabolism Internal fixation in fractures Laboratory animals Leukocytes (neutrophilic) Lymphocytes Males Medical equipment Medical innovations Medical research Medicine and Health Sciences Methicillin Monocytes Neutrophils Osteomyelitis Osteomyelitis - drug therapy Osteomyelitis - immunology Osteomyelitis - microbiology Pathogens Patients Peptides Physiological apparatus Physiological aspects Rabbits Research and Analysis Methods Silk Silk fibroin Staphylococcal Infections - drug therapy Staphylococcal Infections - immunology Staphylococcal Infections - microbiology Staphylococcus Staphylococcus epidermidis Surgical implants Tibia Titanium Transplants & implants Vancomycin Vancomycin - pharmacology Viral infections |
| title | The clinical significance of inflammatory biomarkers, IL6 cytokine, and systemic immune inflammatory index in rabbit model of acute and chronic Methicillin-resistant Staphylococcus epidermidis-induced osteomyelitis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T09%3A53%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20clinical%20significance%20of%20inflammatory%20biomarkers,%20IL6%20cytokine,%20and%20systemic%20immune%20inflammatory%20index%20in%20rabbit%20model%20of%20acute%20and%20chronic%20Methicillin-resistant%20Staphylococcus%20epidermidis-induced%20osteomyelitis&rft.jtitle=PloS%20one&rft.au=Ancu%C8%9Ba,%20Diana-Larisa&rft.date=2024-08-29&rft.volume=19&rft.issue=8&rft.spage=e0309145&rft.pages=e0309145-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0309145&rft_dat=%3Cgale_plos_%3EA806591381%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3098716491&rft_id=info:pmid/39208074&rft_galeid=A806591381&rft_doaj_id=oai_doaj_org_article_579c4ad5795a4a53846352b04f6f9a7f&rfr_iscdi=true |