Identification of breast cancer-associated PIK3CA H1047R mutation in blood circulation using an asymmetric PCR assay

To establish a highly sensitive and specific approach for the detection of circulating PIK3CA H1047R mutation in breast cancer (BC) patients and to investigate the association between the prevalence of PIK3CA H1047R mutation and clinical presentations. A proper blocker was designed in an allele-spec...

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Veröffentlicht in:	PloS one 2024-08, Vol.19 (8), p.e0309209
Hauptverfasser:	Thao, Dinh Thi, Thanh, Nguyen Phu, Quyen, Dong Van, Khai, Ly Tuan, Song, Le Huu, Trung, Ngo Tat
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Alleles Assaying Biology and Life Sciences Biopsy Blood circulation Brain cancer Breast cancer Breast Neoplasms - blood Breast Neoplasms - genetics Cancer therapies Class I Phosphatidylinositol 3-Kinases - genetics Diagnosis ErbB-2 protein Ethics Female Gene mutations Genetic aspects Genetic research Genetic testing Growth factors Humans Identification and classification Leukocytes Liver Lymph nodes Medical research Medicine and Health Sciences Medicine, Experimental Metastases Metastasis Middle Aged Mutants Mutation Neoplasm Staging Plasma Polymerase chain reaction Polymerase Chain Reaction - methods Regulatory approval Research and Analysis Methods Scientific equipment and supplies industry Statistical analysis
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