The impact of sarcopenia on the incidence of postoperative outcomes following spine surgery: Systematic review and meta-analysis
Sarcopenia is considered to be an important predictor of adverse outcomes following spinal surgery, but the specific relationship between the two is not clear. The purpose of this meta-analysis is to systematically review all relevant studies to evaluate the impact of sarcopenia on spinal surgery ou...
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| Veröffentlicht in: | PloS one 2024-08, Vol.19 (8), p.e0302291 |
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| creator | Luo, Mingjiang Mei, Zubing Tang, Siliang Huang, Jinshan Yuan, Kun Jiang, Lingling Tang, Zhifeng Li, Keni Su, Mingxuan Su, Can Shi, Yuxin Zhang, Zihan Chen, Jiang Zheng, Yuan Bin, Peng Yuan, Zhengbing Xu, Guosong Xiao, Zhihong |
| description | Sarcopenia is considered to be an important predictor of adverse outcomes following spinal surgery, but the specific relationship between the two is not clear. The purpose of this meta-analysis is to systematically review all relevant studies to evaluate the impact of sarcopenia on spinal surgery outcomes.
We systematically searched PubMed, Embase and the Cochrane Library for relevant articles published on or before January 9, 2023. The pooled odds ratio (OR) with 95% confidence intervals (CIs) was calculated in a random effects meta-analysis. The main outcome was the risk of adverse outcomes after spinal surgery, including adverse events and mortality. This systematic review and meta-analysis was conducted following the PRISMA guidelines to evaluate the impact of sarcopenia on spinal surgery outcomes. In addition, we also conducted a subgroup analysis and leave-one-out sensitivity analyses to explore the main sources of heterogeneity and the stability of the results.
Twenty-four cohort studies, with a total of 243,453 participants, met the inclusion criteria. The meta-analysis showed that sarcopenia was significantly associated with adverse events (OR 1.63, 95% CI 1.17-2.27, P < 0.001) but was no significantly associated with mortality (OR 1.17, 95% CI 0.93-1.46, P = 0.180), infection (OR 2.24, 95% CI 0.95-5.26, P < 0.001), 30-day reoperation (OR 1.47, 95% CI 0.92-2.36, P = 0.413), deep vein thrombosis (OR 1.78, 95% CI 0.69-4.61, P = 0.234), postoperative home discharge (OR 0.60, 95% CI 0.26-1.37, P = 0.002) and blood transfusion (OR 3.28, 95% CI 0.74-14.64, P = 0.015).
The current meta-analysis showed that patients with sarcopenia have an increased risk of adverse events and mortality after spinal surgery. However, these results must be carefully interpreted because the number of studies included is small and the studies are significantly different. These findings may help to increase the clinicians' awareness of the risks concerning patients with sarcopenia to improve their prognosis. |
| doi_str_mv | 10.1371/journal.pone.0302291 |
| format | Article |
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We systematically searched PubMed, Embase and the Cochrane Library for relevant articles published on or before January 9, 2023. The pooled odds ratio (OR) with 95% confidence intervals (CIs) was calculated in a random effects meta-analysis. The main outcome was the risk of adverse outcomes after spinal surgery, including adverse events and mortality. This systematic review and meta-analysis was conducted following the PRISMA guidelines to evaluate the impact of sarcopenia on spinal surgery outcomes. In addition, we also conducted a subgroup analysis and leave-one-out sensitivity analyses to explore the main sources of heterogeneity and the stability of the results.
Twenty-four cohort studies, with a total of 243,453 participants, met the inclusion criteria. The meta-analysis showed that sarcopenia was significantly associated with adverse events (OR 1.63, 95% CI 1.17-2.27, P < 0.001) but was no significantly associated with mortality (OR 1.17, 95% CI 0.93-1.46, P = 0.180), infection (OR 2.24, 95% CI 0.95-5.26, P < 0.001), 30-day reoperation (OR 1.47, 95% CI 0.92-2.36, P = 0.413), deep vein thrombosis (OR 1.78, 95% CI 0.69-4.61, P = 0.234), postoperative home discharge (OR 0.60, 95% CI 0.26-1.37, P = 0.002) and blood transfusion (OR 3.28, 95% CI 0.74-14.64, P = 0.015).
The current meta-analysis showed that patients with sarcopenia have an increased risk of adverse events and mortality after spinal surgery. However, these results must be carefully interpreted because the number of studies included is small and the studies are significantly different. These findings may help to increase the clinicians' awareness of the risks concerning patients with sarcopenia to improve their prognosis.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0302291</identifier><identifier>PMID: 39186727</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Aging ; Asymmetry ; Back surgery ; Biology and Life Sciences ; Blood transfusion ; Body mass index ; Bone surgery ; Care and treatment ; Complications and side effects ; Health aspects ; Heterogeneity ; Humans ; Impact analysis ; Incidence ; Infections ; Medicine and Health Sciences ; Meta-analysis ; Mortality ; Older people ; Patients ; Physical Sciences ; Physiological aspects ; Postoperative Complications - epidemiology ; Postoperative Complications - etiology ; Postoperative period ; Research and Analysis Methods ; Sarcopenia ; Sarcopenia - complications ; Sarcopenia - epidemiology ; Sensitivity analysis ; Software ; Spinal cord ; Spine ; Spine - surgery ; Subgroups ; Subject heading schemes ; Surgery ; Surgical outcomes ; Systematic review ; Thromboembolism ; Thrombosis</subject><ispartof>PloS one, 2024-08, Vol.19 (8), p.e0302291</ispartof><rights>Copyright: © 2024 Luo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2024 Public Library of Science</rights><rights>2024 Luo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 Luo et al 2024 Luo et al</rights><rights>2024 Luo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-0693-8695 ; 0000-0001-6823-7205</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11346935/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11346935/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,23871,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39186727$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luo, Mingjiang</creatorcontrib><creatorcontrib>Mei, Zubing</creatorcontrib><creatorcontrib>Tang, Siliang</creatorcontrib><creatorcontrib>Huang, Jinshan</creatorcontrib><creatorcontrib>Yuan, Kun</creatorcontrib><creatorcontrib>Jiang, Lingling</creatorcontrib><creatorcontrib>Tang, Zhifeng</creatorcontrib><creatorcontrib>Li, Keni</creatorcontrib><creatorcontrib>Su, Mingxuan</creatorcontrib><creatorcontrib>Su, Can</creatorcontrib><creatorcontrib>Shi, Yuxin</creatorcontrib><creatorcontrib>Zhang, Zihan</creatorcontrib><creatorcontrib>Chen, Jiang</creatorcontrib><creatorcontrib>Zheng, Yuan</creatorcontrib><creatorcontrib>Bin, Peng</creatorcontrib><creatorcontrib>Yuan, Zhengbing</creatorcontrib><creatorcontrib>Xu, Guosong</creatorcontrib><creatorcontrib>Xiao, Zhihong</creatorcontrib><title>The impact of sarcopenia on the incidence of postoperative outcomes following spine surgery: Systematic review and meta-analysis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Sarcopenia is considered to be an important predictor of adverse outcomes following spinal surgery, but the specific relationship between the two is not clear. The purpose of this meta-analysis is to systematically review all relevant studies to evaluate the impact of sarcopenia on spinal surgery outcomes.
We systematically searched PubMed, Embase and the Cochrane Library for relevant articles published on or before January 9, 2023. The pooled odds ratio (OR) with 95% confidence intervals (CIs) was calculated in a random effects meta-analysis. The main outcome was the risk of adverse outcomes after spinal surgery, including adverse events and mortality. This systematic review and meta-analysis was conducted following the PRISMA guidelines to evaluate the impact of sarcopenia on spinal surgery outcomes. In addition, we also conducted a subgroup analysis and leave-one-out sensitivity analyses to explore the main sources of heterogeneity and the stability of the results.
Twenty-four cohort studies, with a total of 243,453 participants, met the inclusion criteria. The meta-analysis showed that sarcopenia was significantly associated with adverse events (OR 1.63, 95% CI 1.17-2.27, P < 0.001) but was no significantly associated with mortality (OR 1.17, 95% CI 0.93-1.46, P = 0.180), infection (OR 2.24, 95% CI 0.95-5.26, P < 0.001), 30-day reoperation (OR 1.47, 95% CI 0.92-2.36, P = 0.413), deep vein thrombosis (OR 1.78, 95% CI 0.69-4.61, P = 0.234), postoperative home discharge (OR 0.60, 95% CI 0.26-1.37, P = 0.002) and blood transfusion (OR 3.28, 95% CI 0.74-14.64, P = 0.015).
The current meta-analysis showed that patients with sarcopenia have an increased risk of adverse events and mortality after spinal surgery. However, these results must be carefully interpreted because the number of studies included is small and the studies are significantly different. These findings may help to increase the clinicians' awareness of the risks concerning patients with sarcopenia to improve their prognosis.</description><subject>Age</subject><subject>Aging</subject><subject>Asymmetry</subject><subject>Back surgery</subject><subject>Biology and Life Sciences</subject><subject>Blood transfusion</subject><subject>Body mass index</subject><subject>Bone surgery</subject><subject>Care and treatment</subject><subject>Complications and side effects</subject><subject>Health aspects</subject><subject>Heterogeneity</subject><subject>Humans</subject><subject>Impact analysis</subject><subject>Incidence</subject><subject>Infections</subject><subject>Medicine and Health Sciences</subject><subject>Meta-analysis</subject><subject>Mortality</subject><subject>Older people</subject><subject>Patients</subject><subject>Physical Sciences</subject><subject>Physiological aspects</subject><subject>Postoperative Complications - epidemiology</subject><subject>Postoperative Complications - etiology</subject><subject>Postoperative period</subject><subject>Research and Analysis Methods</subject><subject>Sarcopenia</subject><subject>Sarcopenia - complications</subject><subject>Sarcopenia - epidemiology</subject><subject>Sensitivity analysis</subject><subject>Software</subject><subject>Spinal cord</subject><subject>Spine</subject><subject>Spine - surgery</subject><subject>Subgroups</subject><subject>Subject heading schemes</subject><subject>Surgery</subject><subject>Surgical outcomes</subject><subject>Systematic 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impact of sarcopenia on the incidence of postoperative outcomes following spine surgery: Systematic review and meta-analysis</title><author>Luo, Mingjiang ; Mei, Zubing ; Tang, Siliang ; Huang, Jinshan ; Yuan, Kun ; Jiang, Lingling ; Tang, Zhifeng ; Li, Keni ; Su, Mingxuan ; Su, Can ; Shi, Yuxin ; Zhang, Zihan ; Chen, Jiang ; Zheng, Yuan ; Bin, Peng ; Yuan, Zhengbing ; Xu, Guosong ; Xiao, Zhihong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-d481t-a5c03d76e1893835d60695fba37f9111b75780dd2cb1e03d8d4aeb86a52efcd73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Age</topic><topic>Aging</topic><topic>Asymmetry</topic><topic>Back surgery</topic><topic>Biology and Life Sciences</topic><topic>Blood transfusion</topic><topic>Body mass index</topic><topic>Bone surgery</topic><topic>Care and treatment</topic><topic>Complications and side effects</topic><topic>Health aspects</topic><topic>Heterogeneity</topic><topic>Humans</topic><topic>Impact analysis</topic><topic>Incidence</topic><topic>Infections</topic><topic>Medicine and Health Sciences</topic><topic>Meta-analysis</topic><topic>Mortality</topic><topic>Older people</topic><topic>Patients</topic><topic>Physical Sciences</topic><topic>Physiological aspects</topic><topic>Postoperative Complications - epidemiology</topic><topic>Postoperative Complications - etiology</topic><topic>Postoperative period</topic><topic>Research and Analysis Methods</topic><topic>Sarcopenia</topic><topic>Sarcopenia - complications</topic><topic>Sarcopenia - epidemiology</topic><topic>Sensitivity analysis</topic><topic>Software</topic><topic>Spinal cord</topic><topic>Spine</topic><topic>Spine - surgery</topic><topic>Subgroups</topic><topic>Subject heading schemes</topic><topic>Surgery</topic><topic>Surgical outcomes</topic><topic>Systematic 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Yuxin</au><au>Zhang, Zihan</au><au>Chen, Jiang</au><au>Zheng, Yuan</au><au>Bin, Peng</au><au>Yuan, Zhengbing</au><au>Xu, Guosong</au><au>Xiao, Zhihong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The impact of sarcopenia on the incidence of postoperative outcomes following spine surgery: Systematic review and meta-analysis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2024-08-26</date><risdate>2024</risdate><volume>19</volume><issue>8</issue><spage>e0302291</spage><pages>e0302291-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Sarcopenia is considered to be an important predictor of adverse outcomes following spinal surgery, but the specific relationship between the two is not clear. The purpose of this meta-analysis is to systematically review all relevant studies to evaluate the impact of sarcopenia on spinal surgery outcomes.
We systematically searched PubMed, Embase and the Cochrane Library for relevant articles published on or before January 9, 2023. The pooled odds ratio (OR) with 95% confidence intervals (CIs) was calculated in a random effects meta-analysis. The main outcome was the risk of adverse outcomes after spinal surgery, including adverse events and mortality. This systematic review and meta-analysis was conducted following the PRISMA guidelines to evaluate the impact of sarcopenia on spinal surgery outcomes. In addition, we also conducted a subgroup analysis and leave-one-out sensitivity analyses to explore the main sources of heterogeneity and the stability of the results.
Twenty-four cohort studies, with a total of 243,453 participants, met the inclusion criteria. The meta-analysis showed that sarcopenia was significantly associated with adverse events (OR 1.63, 95% CI 1.17-2.27, P < 0.001) but was no significantly associated with mortality (OR 1.17, 95% CI 0.93-1.46, P = 0.180), infection (OR 2.24, 95% CI 0.95-5.26, P < 0.001), 30-day reoperation (OR 1.47, 95% CI 0.92-2.36, P = 0.413), deep vein thrombosis (OR 1.78, 95% CI 0.69-4.61, P = 0.234), postoperative home discharge (OR 0.60, 95% CI 0.26-1.37, P = 0.002) and blood transfusion (OR 3.28, 95% CI 0.74-14.64, P = 0.015).
The current meta-analysis showed that patients with sarcopenia have an increased risk of adverse events and mortality after spinal surgery. However, these results must be carefully interpreted because the number of studies included is small and the studies are significantly different. These findings may help to increase the clinicians' awareness of the risks concerning patients with sarcopenia to improve their prognosis.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>39186727</pmid><doi>10.1371/journal.pone.0302291</doi><tpages>e0302291</tpages><orcidid>https://orcid.org/0000-0002-0693-8695</orcidid><orcidid>https://orcid.org/0000-0001-6823-7205</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2024-08, Vol.19 (8), p.e0302291 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_3097454242 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS) Journals Open Access; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Age Aging Asymmetry Back surgery Biology and Life Sciences Blood transfusion Body mass index Bone surgery Care and treatment Complications and side effects Health aspects Heterogeneity Humans Impact analysis Incidence Infections Medicine and Health Sciences Meta-analysis Mortality Older people Patients Physical Sciences Physiological aspects Postoperative Complications - epidemiology Postoperative Complications - etiology Postoperative period Research and Analysis Methods Sarcopenia Sarcopenia - complications Sarcopenia - epidemiology Sensitivity analysis Software Spinal cord Spine Spine - surgery Subgroups Subject heading schemes Surgery Surgical outcomes Systematic review Thromboembolism Thrombosis |
| title | The impact of sarcopenia on the incidence of postoperative outcomes following spine surgery: Systematic review and meta-analysis |
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