Mechanism of action and synergistic effect of Eugenia uniflora extract in Candida spp

The limited arsenal of antifungal drugs have prompted the search for novel molecules with biological activity. This study aimed to characterize the antifungal mechanism of action of Eugenia uniflora extract and its synergistic activity with commercially available antifungal drugs on the following Ca...

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Veröffentlicht in:	PloS one 2024-08, Vol.19 (8), p.e0303878
Hauptverfasser:	Souza, Luanda B F C, de Oliveira Bento, Aurélio, Lourenço, Estela M G, Ferreira, Magda R A, Oliveira, Wogenes N, Soares, Luiz Alberto L, G Barbosa, Euzébio, Rocha, Hugo A O, Chaves, Guilherme Maranhão
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Amino acids Amphotericin B Analysis Antifungal activity Antifungal agents Antifungal Agents - pharmacology Biological activity Biological effects Biology and Life Sciences Biosynthesis Candida Candida - drug effects Cell Membrane - drug effects Cell Membrane - metabolism Cell walls Chromatography Drug Synergism Drugs Enzymes Ergosterol Eugenia - chemistry Eugenia uniflora Fluconazole Fluconazole - pharmacology Fungicides Infections Integrity Investigations Iodides Leaves Medicine and Health Sciences Membranes Micafungin Microbial Sensitivity Tests Molecular docking Molecular Docking Simulation Natural products Pharmaceutical industry Physical Sciences Physiological aspects Phytosterols Plant Extracts - chemistry Plant Extracts - pharmacology Propidium iodide Research and Analysis Methods Simulation Software Sorbitol Sterols Synergism Synergistic effect Toxicity Yeast Yeasts
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