Ginkgo biloba extract inhibits hippocampal neuronal injury caused by mitochondrial oxidative stress in a rat model of Alzheimer's disease

Ginkgo biloba extracts (GBE) have been shown to effectively improve cognitive function in patients with Alzheimer's disease (AD). One potential therapeutic strategy for AD is to prevent loss of adult hippocampal neurons. While recent studies have reported that GBE protects against oxidative str...

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Veröffentlicht in:	PloS one 2024-08, Vol.19 (8), p.e0307735
Hauptverfasser:	Xia, Chenyi, Zhou, Mingmei, Dong, Xianwen, Zhao, Yan, Jiang, Meifang, Zhu, Guoqin, Zhang, Zhixiong
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Hydroxydeoxyguanosine Advertising executives Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer's disease Amine oxidase (flavin-containing) Amyloid beta-Peptides - metabolism Animal cognition Animals Apoptosis Apoptosis - drug effects BAX protein Bcl-2 protein Biology and Life Sciences Brain research CAD Caspase-3 China Chinese medicine Cognitive ability Computer aided design Cytochrome c Deoxyribonuclease Deoxyribonucleic acid Disease Models, Animal Diseases DNA DNA damage Enzymes Flavonoids Gene expression Ginkgo biloba Ginkgo biloba - chemistry Ginkgo Extract Glutathione Glutathione peroxidase Health aspects Hippocampus Hippocampus - drug effects Hippocampus - metabolism Hydrogen peroxide Hydrogen Peroxide - metabolism Injury prevention Male Medicine and Health Sciences Mitochondria Mitochondria - drug effects Mitochondria - metabolism Monoamine oxidase Neurodegenerative diseases Neurogenesis Neurons Neurons - drug effects Neurons - metabolism Oral administration Oxidation Oxidative stress Oxidative Stress - drug effects Pathogenesis Peptide Fragments Peroxidase Peroxidation Plant Extracts - pharmacology Proteins Rats Rats, Sprague-Dawley Superoxide Superoxide dismutase Vitamin E
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