Combinatorial actions of IL-22 and IL-17 drive optimal immunity to oral candidiasis through SPRRs

Oropharyngeal candidiasis (OPC) is the most common human fungal infection, arising typically from T cell immune impairments. IL-17 and IL-22 contribute individually to OPC responses, but here we demonstrate that the combined actions of both cytokines are essential for resistance to OPC. Mice lacking...

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Veröffentlicht in:	PLoS pathogens 2024-07, Vol.20 (7), p.e1012302
Hauptverfasser:	Aggor, Felix E Y, Bertolini, Martinna, Coleman, Bianca M, Taylor, Tiffany C, Ponde, Nicole O, Gaffen, Sarah L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biology and Life Sciences Candida albicans - immunology Candidiasis Candidiasis, Oral - immunology Candidiasis, Oral - microbiology Colitis Colon Combinatorial analysis Cytokines Engineering and Technology Esophagus Fungi Gene expression Health aspects Immune response Immunity Interleukin 17 Interleukin 22 Interleukin-17 - immunology Interleukin-17 - metabolism Interleukins Interleukins - immunology Interleukins - metabolism Keratin Kinases Lymphocytes Lymphocytes T Medical research Medicine and Health Sciences Medicine, Experimental Mice Mice, Inbred C57BL Mice, Knockout Physiological aspects Proteins Receptors, Interleukin - immunology Receptors, Interleukin - metabolism Receptors, Interleukin-17 - immunology Receptors, Interleukin-17 - metabolism Short Reports Thrush (Mouth disease) Weight loss
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