Human coronavirus NL63 nsp1 induces degradation of RNA polymerase II to inhibit host protein synthesis

Coronavirus (CoV) nonstructural protein 1 (nsp1) is considered a pathogenic factor due to its ability to inhibit host antiviral responses by inducing general shutoff of host protein synthesis. Nsp1 is expressed by α- and β-CoVs, but its functions and strategies to induce host shutoff are not fully e...

Ausführliche Beschreibung