Evaluation of ex vivo drug combination optimization platform in recurrent high grade astrocytic glioma: An interventional, non-randomized, open-label trial protocol

High grade astrocytic glioma (HGG) is a lethal solid malignancy with high recurrence rates and limited survival. While several cytotoxic agents have demonstrated efficacy against HGG, drug sensitivity testing platforms to aid in therapy selection are lacking. Patient-derived organoids (PDOs) have be...

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Veröffentlicht in:	PloS one 2024-07, Vol.19 (7), p.e0307818
Hauptverfasser:	Toh, Tan Boon, Thng, Dexter Kai Hao, Bolem, Nagarjun, Vellayappan, Balamurugan A, Tan, Bryce Wei Quan, Shen, Yating, Soon, Sou Yen, Ang, Yvonne Li En, Dinesh, Nivedh, Teo, Kejia, Nga, Vincent Diong Weng, Low, Shiong Wen, Khong, Pek Lan, Chow, Edward Kai-Hua, Ho, Dean, Yeo, Tseng Tsai, Wong, Andrea Li Ann
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Antimitotic agents Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - therapeutic use Astrocytoma - diagnostic imaging Astrocytoma - drug therapy Astrocytoma - pathology Biomarkers Biopsy Blood-brain barrier Brain cancer Brain Neoplasms - diagnostic imaging Brain Neoplasms - drug therapy Brain Neoplasms - pathology Brain tumors Cancer Cancer therapies Care and treatment Cell culture Chemotherapy Clinical trials Cytotoxic agents Cytotoxicity Drug sensitivity testing Drug therapy, Combination Drugs Glioma Gliomas Health aspects Humans Hypotheses Hypothesis testing In vivo methods and tests Labels Magnetic resonance imaging Malignancy Medical imaging Membrane permeability Neoplasm Grading Neoplasm Recurrence, Local - drug therapy Neoplasm Recurrence, Local - pathology Neuroimaging Optimization Organoids Organoids - diagnostic imaging Organoids - drug effects Organoids - pathology Patients Permeability Pharmaceuticals Radiochemical analysis Radioisotopes Sample size Sensitivity analysis Surgery Survival Tumors
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