Select amino acids recover cytokine-altered ENaC function in human bronchial epithelial cells

The airway epithelium plays a pivotal role in regulating mucosal immunity and inflammation. Epithelial barrier function, homeostasis of luminal fluid, and mucociliary clearance are major components of mucosal defense mechanisms. The epithelial sodium channel (ENaC) is one of the key players in contr...

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Veröffentlicht in:	PloS one 2024-07, Vol.19 (7), p.e0307809
Hauptverfasser:	Sasidharan, Anusree, Grosche, Astrid, Xu, Xiaodong, Kinane, T Bernard, Angoli, Damiano, Vidyasagar, Sadasivan
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergic reactions Allergies Amino acids Amino Acids - pharmacology Biology and Life Sciences Bronchi - cytology Bronchi - drug effects Bronchi - metabolism Cell culture Cell Line Cytokines Cytokines - metabolism Epithelial cells Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelial Sodium Channels - genetics Epithelial Sodium Channels - metabolism Epithelium Gene expression Health aspects Homeostasis Humans Immune clearance Immune response Inflammation Interleukin 13 Interleukin-13 - metabolism Intestine Ion channels Lung diseases Lymphocytes T Medicine and Health Sciences Membrane proteins Microorganisms mRNA Mucosal immunity Penicillin Permeability Protein expression Proteins R&D Research & development Research and Analysis Methods Respiratory tract Review boards RNA Sodium Th1 Cells - drug effects Th1 Cells - immunology Th1 Cells - metabolism Th2 Cells - drug effects Th2 Cells - immunology Th2 Cells - metabolism Transforming growth factor-b1 Transforming growth factors Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α γ-Interferon
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