CircRNA_012164/MicroRNA-9-5p axis mediates cardiac fibrosis in diabetic cardiomyopathy

Noncoding RNAs play a part in many chronic diseases and interact with each other to regulate gene expression. MicroRNA-9-5p (miR9) has been thought to be a potential inhibitor of diabetic cardiomyopathy. Here we examined the role of miR9 in regulating cardiac fibrosis in the context of diabetic card...

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Veröffentlicht in:	PloS one 2024-07, Vol.19 (7), p.e0302772
Hauptverfasser:	Wang, Honglin, Wang, Eric Zi Rui, Feng, Biao, Chakrabarti, Subrata
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antisense RNA Atherosclerosis Biology and Life Sciences Cardiomyocytes Cardiomyopathy Cardiovascular disease Cell proliferation Cell Proliferation - genetics Chromosome 5 Chronic diseases Circular RNA Coronary artery disease Coronary vessels Dextrose Diabetes Diabetes mellitus Diabetic Cardiomyopathies - genetics Diabetic Cardiomyopathies - metabolism Diabetic Cardiomyopathies - pathology Diabetic neuropathy DNA methylation Endothelial cells Endothelial Cells - metabolism Endothelial Cells - pathology Endothelium Engineering and Technology Epigenetics Fibroblasts Fibrosis Gene expression Gene Expression Regulation Genes Genetic aspects Genetic transcription Glucose Glucose - metabolism Heart Heart diseases Hyperglycemia Hypertension In vivo methods and tests Laboratories Male Medicine and Health Sciences Mice Mice, Inbred C57BL MicroRNA MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA Myocardium - metabolism Myocardium - pathology Non-coding RNA Oxidative stress Physical Sciences Rats RNA - genetics RNA - metabolism RNA, Circular - genetics RNA, Circular - metabolism Type 2 diabetes Up-regulation Vein & artery diseases
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