Targeted vibratory therapy as a treatment for proprioceptive dysfunction: Clinical trial in older patients with chronic low back pain
Proprioceptive function declines with age, leading to falls, pain, and difficulties in performing activities of daily living among older adults. Although individuals with low back pain (LBP) exhibit decreased lumbosacral proprioception in various postures, the mechanism by which reduced propriocepti...
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| creator | Sakai, Yoshihito Morita, Yoshifumi Kawai, Keitaro Fukuhara, Jo Ito, Tadashi Yamazaki, Kazunori Watanabe, Tsuyoshi Wakao, Norimitsu Matsui, Hiroki |
| description | Proprioceptive function declines with age, leading to falls, pain, and difficulties in performing activities of daily living among older adults. Although individuals with low back pain (LBP) exhibit decreased lumbosacral proprioception in various postures, the mechanism by which reduced proprioceptive function causes LBP remains uncertain. Vibratory stimulation may enhance proprioceptive function; however, its efficacy in treating LBP has not been investigated. Thus, we investigated the feasibility of improving proprioceptive function and its effect on alleviating chronic LBP in older patients through targeted vibratory therapy (TVT) administration.
This single arm designed trial included older patients aged >65 years with non-specific chronic LBP. TVT involved applying vibratory stimulation, matching the frequency of dysfunctional receptors, for 1 min daily over 14 days to activate proprioceptors; patients performed TVT three times daily at home. In cases of reduced proprioceptive function at multiple sites, TVT was aimed at the lowest frequency band value. LBP and proprioceptive function were evaluated at 2 weeks after TVT and at 2 weeks after the end of TVT in patients with declined proprioception in the trunk or lower extremities.
Overall, 56 patients with chronic LBP were enrolled; 32 patients were recruited for treatment based on a proprioceptive dysfunction diagnosis and 24 patients were recruited with a normal diagnosis with no significant differences observed between the two sets of patients in sarcopenia-related factors and clinical proprioception-related characteristics. No patient had any adverse events. Two weeks after TVT, the numerical pain rating scale score improved to |
| doi_str_mv | 10.1371/journal.pone.0306898 |
| format | Article |
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This single arm designed trial included older patients aged >65 years with non-specific chronic LBP. TVT involved applying vibratory stimulation, matching the frequency of dysfunctional receptors, for 1 min daily over 14 days to activate proprioceptors; patients performed TVT three times daily at home. In cases of reduced proprioceptive function at multiple sites, TVT was aimed at the lowest frequency band value. LBP and proprioceptive function were evaluated at 2 weeks after TVT and at 2 weeks after the end of TVT in patients with declined proprioception in the trunk or lower extremities.
Overall, 56 patients with chronic LBP were enrolled; 32 patients were recruited for treatment based on a proprioceptive dysfunction diagnosis and 24 patients were recruited with a normal diagnosis with no significant differences observed between the two sets of patients in sarcopenia-related factors and clinical proprioception-related characteristics. No patient had any adverse events. Two weeks after TVT, the numerical pain rating scale score improved to <3 points in 78.1% of patients, with 73.1% of patients achieving a score of ≤ 3 points. Proprioceptive function improved in 81.3% of cases, and engagement in activities of daily living improved significantly.
TVT demonstrated efficacy in improving proprioception and alleviating LBP in older patients with impaired proprioceptive function without affecting non-targeted proprioceptors.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0306898</identifier><identifier>PMID: 39028706</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Activities of Daily Living ; Aged ; Aged patients ; Aged, 80 and over ; Back pain ; Backache ; Chronic pain ; Chronic Pain - physiopathology ; Chronic Pain - therapy ; Clinical trials ; Diagnosis ; Effectiveness ; Extremities ; Female ; Frequencies ; Humans ; Low back pain ; Low Back Pain - physiopathology ; Low Back Pain - therapy ; Magnetic resonance imaging ; Male ; Musculoskeletal system ; Nonsteroidal anti-inflammatory drugs ; Older people ; Pain ; Patients ; Posture ; Proprioception ; Proprioception - physiology ; Proprioceptors ; Receptor mechanisms ; Sarcopenia ; Stimulation ; Tendons ; Treatment Outcome ; Vibration ; Vibration - therapeutic use</subject><ispartof>PloS one, 2024-07, Vol.19 (7), p.e0306898</ispartof><rights>Copyright: © 2024 Sakai et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2024 Public Library of Science</rights><rights>2024 Sakai et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 Sakai et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c516t-e67cadd753bfee51812058883b592a1fa00359d2f01f118f458224443708c1be3</cites><orcidid>0000-0001-6507-7859 ; 0000-0002-4246-751X ; 0000-0002-5427-7609</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,2102,2928,23866,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39028706$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Blasco, Jose María</contributor><creatorcontrib>Sakai, Yoshihito</creatorcontrib><creatorcontrib>Morita, Yoshifumi</creatorcontrib><creatorcontrib>Kawai, Keitaro</creatorcontrib><creatorcontrib>Fukuhara, Jo</creatorcontrib><creatorcontrib>Ito, Tadashi</creatorcontrib><creatorcontrib>Yamazaki, Kazunori</creatorcontrib><creatorcontrib>Watanabe, Tsuyoshi</creatorcontrib><creatorcontrib>Wakao, Norimitsu</creatorcontrib><creatorcontrib>Matsui, Hiroki</creatorcontrib><title>Targeted vibratory therapy as a treatment for proprioceptive dysfunction: Clinical trial in older patients with chronic low back pain</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Proprioceptive function declines with age, leading to falls, pain, and difficulties in performing activities of daily living among older adults. Although individuals with low back pain (LBP) exhibit decreased lumbosacral proprioception in various postures, the mechanism by which reduced proprioceptive function causes LBP remains uncertain. Vibratory stimulation may enhance proprioceptive function; however, its efficacy in treating LBP has not been investigated. Thus, we investigated the feasibility of improving proprioceptive function and its effect on alleviating chronic LBP in older patients through targeted vibratory therapy (TVT) administration.
This single arm designed trial included older patients aged >65 years with non-specific chronic LBP. TVT involved applying vibratory stimulation, matching the frequency of dysfunctional receptors, for 1 min daily over 14 days to activate proprioceptors; patients performed TVT three times daily at home. In cases of reduced proprioceptive function at multiple sites, TVT was aimed at the lowest frequency band value. LBP and proprioceptive function were evaluated at 2 weeks after TVT and at 2 weeks after the end of TVT in patients with declined proprioception in the trunk or lower extremities.
Overall, 56 patients with chronic LBP were enrolled; 32 patients were recruited for treatment based on a proprioceptive dysfunction diagnosis and 24 patients were recruited with a normal diagnosis with no significant differences observed between the two sets of patients in sarcopenia-related factors and clinical proprioception-related characteristics. No patient had any adverse events. Two weeks after TVT, the numerical pain rating scale score improved to <3 points in 78.1% of patients, with 73.1% of patients achieving a score of ≤ 3 points. Proprioceptive function improved in 81.3% of cases, and engagement in activities of daily living improved significantly.
TVT demonstrated efficacy in improving proprioception and alleviating LBP in older patients with impaired proprioceptive function without affecting non-targeted proprioceptors.</description><subject>Activities of Daily Living</subject><subject>Aged</subject><subject>Aged patients</subject><subject>Aged, 80 and over</subject><subject>Back pain</subject><subject>Backache</subject><subject>Chronic pain</subject><subject>Chronic Pain - physiopathology</subject><subject>Chronic Pain - therapy</subject><subject>Clinical trials</subject><subject>Diagnosis</subject><subject>Effectiveness</subject><subject>Extremities</subject><subject>Female</subject><subject>Frequencies</subject><subject>Humans</subject><subject>Low back pain</subject><subject>Low Back Pain - physiopathology</subject><subject>Low Back Pain - therapy</subject><subject>Magnetic resonance imaging</subject><subject>Male</subject><subject>Musculoskeletal system</subject><subject>Nonsteroidal anti-inflammatory drugs</subject><subject>Older people</subject><subject>Pain</subject><subject>Patients</subject><subject>Posture</subject><subject>Proprioception</subject><subject>Proprioception - 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Academic</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sakai, Yoshihito</au><au>Morita, Yoshifumi</au><au>Kawai, Keitaro</au><au>Fukuhara, Jo</au><au>Ito, Tadashi</au><au>Yamazaki, Kazunori</au><au>Watanabe, Tsuyoshi</au><au>Wakao, Norimitsu</au><au>Matsui, Hiroki</au><au>Blasco, Jose María</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Targeted vibratory therapy as a treatment for proprioceptive dysfunction: Clinical trial in older patients with chronic low back pain</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2024-07-19</date><risdate>2024</risdate><volume>19</volume><issue>7</issue><spage>e0306898</spage><pages>e0306898-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Proprioceptive function declines with age, leading to falls, pain, and difficulties in performing activities of daily living among older adults. Although individuals with low back pain (LBP) exhibit decreased lumbosacral proprioception in various postures, the mechanism by which reduced proprioceptive function causes LBP remains uncertain. Vibratory stimulation may enhance proprioceptive function; however, its efficacy in treating LBP has not been investigated. Thus, we investigated the feasibility of improving proprioceptive function and its effect on alleviating chronic LBP in older patients through targeted vibratory therapy (TVT) administration.
This single arm designed trial included older patients aged >65 years with non-specific chronic LBP. TVT involved applying vibratory stimulation, matching the frequency of dysfunctional receptors, for 1 min daily over 14 days to activate proprioceptors; patients performed TVT three times daily at home. In cases of reduced proprioceptive function at multiple sites, TVT was aimed at the lowest frequency band value. LBP and proprioceptive function were evaluated at 2 weeks after TVT and at 2 weeks after the end of TVT in patients with declined proprioception in the trunk or lower extremities.
Overall, 56 patients with chronic LBP were enrolled; 32 patients were recruited for treatment based on a proprioceptive dysfunction diagnosis and 24 patients were recruited with a normal diagnosis with no significant differences observed between the two sets of patients in sarcopenia-related factors and clinical proprioception-related characteristics. No patient had any adverse events. Two weeks after TVT, the numerical pain rating scale score improved to <3 points in 78.1% of patients, with 73.1% of patients achieving a score of ≤ 3 points. Proprioceptive function improved in 81.3% of cases, and engagement in activities of daily living improved significantly.
TVT demonstrated efficacy in improving proprioception and alleviating LBP in older patients with impaired proprioceptive function without affecting non-targeted proprioceptors.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>39028706</pmid><doi>10.1371/journal.pone.0306898</doi><tpages>e0306898</tpages><orcidid>https://orcid.org/0000-0001-6507-7859</orcidid><orcidid>https://orcid.org/0000-0002-4246-751X</orcidid><orcidid>https://orcid.org/0000-0002-5427-7609</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2024-07, Vol.19 (7), p.e0306898 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_3082816230 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS) Journals Open Access; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Activities of Daily Living Aged Aged patients Aged, 80 and over Back pain Backache Chronic pain Chronic Pain - physiopathology Chronic Pain - therapy Clinical trials Diagnosis Effectiveness Extremities Female Frequencies Humans Low back pain Low Back Pain - physiopathology Low Back Pain - therapy Magnetic resonance imaging Male Musculoskeletal system Nonsteroidal anti-inflammatory drugs Older people Pain Patients Posture Proprioception Proprioception - physiology Proprioceptors Receptor mechanisms Sarcopenia Stimulation Tendons Treatment Outcome Vibration Vibration - therapeutic use |
| title | Targeted vibratory therapy as a treatment for proprioceptive dysfunction: Clinical trial in older patients with chronic low back pain |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-19T08%3A03%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Targeted%20vibratory%20therapy%20as%20a%20treatment%20for%20proprioceptive%20dysfunction:%20Clinical%20trial%20in%20older%20patients%20with%20chronic%20low%20back%20pain&rft.jtitle=PloS%20one&rft.au=Sakai,%20Yoshihito&rft.date=2024-07-19&rft.volume=19&rft.issue=7&rft.spage=e0306898&rft.pages=e0306898-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0306898&rft_dat=%3Cgale_plos_%3EA801937714%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3082816230&rft_id=info:pmid/39028706&rft_galeid=A801937714&rft_doaj_id=oai_doaj_org_article_bd29f03af1cf4a5db0368f65436b8f2f&rfr_iscdi=true |