Long-term survival outcomes of endoscopic therapy vs. surgical resection in patients with cardia gastrointestinal stromal tumor
The ideal surgical approach for treating cardia gastrointestinal stromal tumor (GIST) is not clearly established. This study aimed to assess the long-term survival results among patients who received endoscopic therapy (ET) or surgical resection (SR) for cardia GIST. Cardia GIST patients from 2000 t...
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| description | The ideal surgical approach for treating cardia gastrointestinal stromal tumor (GIST) is not clearly established. This study aimed to assess the long-term survival results among patients who received endoscopic therapy (ET) or surgical resection (SR) for cardia GIST. Cardia GIST patients from 2000 to 2019 were selected from the surveillance, epidemiology, and end result (SEER) database. Multiple imputation (MI) was applied to handle missing data, and propensity score matching (PSM) was carried out to mitigate selection bias during comparisons. Demographic and clinical characteristics' effects on overall survival (OS) and cancer-specific survival (CSS) were assessed using Kaplan-Meier analyses and multivariate Cox proportional hazard models. A total of 330 patients with cardia GIST were enrolled, including 47 (14.2%) patients with ET and 283 (85.8%) patients with SR. The 5-year OS and CSS rates in the ET and SR groups were comparable [before PSM, (OS) (76.1% vs. 81.2%, P = 0.722), (CSS) (95.0% vs. 89.3%, P = 0.186); after PSM, (OS) (75.4% vs. 85.4%, P = 0.540), (CSS) (94.9% vs. 92.0%, P = 0.099)]. Moreover, there was no significant difference between ET and SR in terms of long-term OS (hazard ratio [HR] 0.735, 95% confidence interval [CI] 0.422-1.282) and CSS (HR 1.560, 95% CI 0.543-4.481). Our study found no significant disparity in long-term survival outcomes between ET and SR in cardia GIST patients, implying that ET could be a valid surgical strategy for treating cardia GIST. |
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This study aimed to assess the long-term survival results among patients who received endoscopic therapy (ET) or surgical resection (SR) for cardia GIST. Cardia GIST patients from 2000 to 2019 were selected from the surveillance, epidemiology, and end result (SEER) database. Multiple imputation (MI) was applied to handle missing data, and propensity score matching (PSM) was carried out to mitigate selection bias during comparisons. Demographic and clinical characteristics' effects on overall survival (OS) and cancer-specific survival (CSS) were assessed using Kaplan-Meier analyses and multivariate Cox proportional hazard models. A total of 330 patients with cardia GIST were enrolled, including 47 (14.2%) patients with ET and 283 (85.8%) patients with SR. The 5-year OS and CSS rates in the ET and SR groups were comparable [before PSM, (OS) (76.1% vs. 81.2%, P = 0.722), (CSS) (95.0% vs. 89.3%, P = 0.186); after PSM, (OS) (75.4% vs. 85.4%, P = 0.540), (CSS) (94.9% vs. 92.0%, P = 0.099)]. Moreover, there was no significant difference between ET and SR in terms of long-term OS (hazard ratio [HR] 0.735, 95% confidence interval [CI] 0.422-1.282) and CSS (HR 1.560, 95% CI 0.543-4.481). Our study found no significant disparity in long-term survival outcomes between ET and SR in cardia GIST patients, implying that ET could be a valid surgical strategy for treating cardia GIST.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0306598</identifier><identifier>PMID: 38968220</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Age ; Aged ; Analysis ; Biology and Life Sciences ; Cancer ; Cancer therapies ; Cardia - pathology ; Cardia - surgery ; Care and treatment ; Chemotherapy ; Codes ; Endoscopy ; Epidemiology ; Female ; Females ; Gastrointestinal cancer ; Gastrointestinal Stromal Tumors - mortality ; Gastrointestinal Stromal Tumors - pathology ; Gastrointestinal Stromal Tumors - surgery ; Gastrointestinal surgery ; Humans ; Kaplan-Meier Estimate ; Male ; Marital status ; Medical prognosis ; Medicine and Health Sciences ; Middle Aged ; Missing data ; Patient outcomes ; Patients ; Propensity Score ; Proportional Hazards Models ; Regression analysis ; Retrospective Studies ; SEER Program ; Statistical models ; Stomach Neoplasms - mortality ; Stomach Neoplasms - pathology ; Stomach Neoplasms - surgery ; Surgery ; Survival ; Survival Rate ; Treatment Outcome ; Tumors</subject><ispartof>PloS one, 2024-07, Vol.19 (7), p.e0306598</ispartof><rights>Copyright: © 2024 Wu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2024 Public Library of Science</rights><rights>2024 Wu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 Wu et al 2024 Wu et al</rights><rights>2024 Wu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c572t-94f39fe67ca08e6293769758e38eb9e1fcbf9bc9ea2fd1e2762902efe8284253</cites><orcidid>0000-0002-9079-956X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11226052/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11226052/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38968220$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>de Nigris, Filomena</contributor><creatorcontrib>Wu, Qiong</creatorcontrib><creatorcontrib>Jiang, Jun</creatorcontrib><creatorcontrib>Li, Zhuofan</creatorcontrib><creatorcontrib>Ling, Xin</creatorcontrib><creatorcontrib>Qiao, Zhenguo</creatorcontrib><creatorcontrib>Ma, Yimin</creatorcontrib><title>Long-term survival outcomes of endoscopic therapy vs. surgical resection in patients with cardia gastrointestinal stromal tumor</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The ideal surgical approach for treating cardia gastrointestinal stromal tumor (GIST) is not clearly established. This study aimed to assess the long-term survival results among patients who received endoscopic therapy (ET) or surgical resection (SR) for cardia GIST. Cardia GIST patients from 2000 to 2019 were selected from the surveillance, epidemiology, and end result (SEER) database. Multiple imputation (MI) was applied to handle missing data, and propensity score matching (PSM) was carried out to mitigate selection bias during comparisons. Demographic and clinical characteristics' effects on overall survival (OS) and cancer-specific survival (CSS) were assessed using Kaplan-Meier analyses and multivariate Cox proportional hazard models. A total of 330 patients with cardia GIST were enrolled, including 47 (14.2%) patients with ET and 283 (85.8%) patients with SR. The 5-year OS and CSS rates in the ET and SR groups were comparable [before PSM, (OS) (76.1% vs. 81.2%, P = 0.722), (CSS) (95.0% vs. 89.3%, P = 0.186); after PSM, (OS) (75.4% vs. 85.4%, P = 0.540), (CSS) (94.9% vs. 92.0%, P = 0.099)]. Moreover, there was no significant difference between ET and SR in terms of long-term OS (hazard ratio [HR] 0.735, 95% confidence interval [CI] 0.422-1.282) and CSS (HR 1.560, 95% CI 0.543-4.481). Our study found no significant disparity in long-term survival outcomes between ET and SR in cardia GIST patients, implying that ET could be a valid surgical strategy for treating cardia GIST.</description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Analysis</subject><subject>Biology and Life Sciences</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Cardia - pathology</subject><subject>Cardia - surgery</subject><subject>Care and treatment</subject><subject>Chemotherapy</subject><subject>Codes</subject><subject>Endoscopy</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Females</subject><subject>Gastrointestinal cancer</subject><subject>Gastrointestinal Stromal Tumors - mortality</subject><subject>Gastrointestinal Stromal Tumors - pathology</subject><subject>Gastrointestinal Stromal Tumors - surgery</subject><subject>Gastrointestinal surgery</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Marital status</subject><subject>Medical prognosis</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Missing data</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Propensity Score</subject><subject>Proportional Hazards Models</subject><subject>Regression analysis</subject><subject>Retrospective Studies</subject><subject>SEER Program</subject><subject>Statistical models</subject><subject>Stomach Neoplasms - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Qiong</au><au>Jiang, Jun</au><au>Li, Zhuofan</au><au>Ling, Xin</au><au>Qiao, Zhenguo</au><au>Ma, Yimin</au><au>de Nigris, Filomena</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term survival outcomes of endoscopic therapy vs. surgical resection in patients with cardia gastrointestinal stromal tumor</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2024-07-05</date><risdate>2024</risdate><volume>19</volume><issue>7</issue><spage>e0306598</spage><pages>e0306598-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The ideal surgical approach for treating cardia gastrointestinal stromal tumor (GIST) is not clearly established. This study aimed to assess the long-term survival results among patients who received endoscopic therapy (ET) or surgical resection (SR) for cardia GIST. Cardia GIST patients from 2000 to 2019 were selected from the surveillance, epidemiology, and end result (SEER) database. Multiple imputation (MI) was applied to handle missing data, and propensity score matching (PSM) was carried out to mitigate selection bias during comparisons. Demographic and clinical characteristics' effects on overall survival (OS) and cancer-specific survival (CSS) were assessed using Kaplan-Meier analyses and multivariate Cox proportional hazard models. A total of 330 patients with cardia GIST were enrolled, including 47 (14.2%) patients with ET and 283 (85.8%) patients with SR. The 5-year OS and CSS rates in the ET and SR groups were comparable [before PSM, (OS) (76.1% vs. 81.2%, P = 0.722), (CSS) (95.0% vs. 89.3%, P = 0.186); after PSM, (OS) (75.4% vs. 85.4%, P = 0.540), (CSS) (94.9% vs. 92.0%, P = 0.099)]. Moreover, there was no significant difference between ET and SR in terms of long-term OS (hazard ratio [HR] 0.735, 95% confidence interval [CI] 0.422-1.282) and CSS (HR 1.560, 95% CI 0.543-4.481). Our study found no significant disparity in long-term survival outcomes between ET and SR in cardia GIST patients, implying that ET could be a valid surgical strategy for treating cardia GIST.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>38968220</pmid><doi>10.1371/journal.pone.0306598</doi><tpages>e0306598</tpages><orcidid>https://orcid.org/0000-0002-9079-956X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Aged Analysis Biology and Life Sciences Cancer Cancer therapies Cardia - pathology Cardia - surgery Care and treatment Chemotherapy Codes Endoscopy Epidemiology Female Females Gastrointestinal cancer Gastrointestinal Stromal Tumors - mortality Gastrointestinal Stromal Tumors - pathology Gastrointestinal Stromal Tumors - surgery Gastrointestinal surgery Humans Kaplan-Meier Estimate Male Marital status Medical prognosis Medicine and Health Sciences Middle Aged Missing data Patient outcomes Patients Propensity Score Proportional Hazards Models Regression analysis Retrospective Studies SEER Program Statistical models Stomach Neoplasms - mortality Stomach Neoplasms - pathology Stomach Neoplasms - surgery Surgery Survival Survival Rate Treatment Outcome Tumors |
| title | Long-term survival outcomes of endoscopic therapy vs. surgical resection in patients with cardia gastrointestinal stromal tumor |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T09%3A47%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Long-term%20survival%20outcomes%20of%20endoscopic%20therapy%20vs.%20surgical%20resection%20in%20patients%20with%20cardia%20gastrointestinal%20stromal%20tumor&rft.jtitle=PloS%20one&rft.au=Wu,%20Qiong&rft.date=2024-07-05&rft.volume=19&rft.issue=7&rft.spage=e0306598&rft.pages=e0306598-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0306598&rft_dat=%3Cgale_plos_%3EA800174372%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3076243497&rft_id=info:pmid/38968220&rft_galeid=A800174372&rft_doaj_id=oai_doaj_org_article_d90fdfbe6b01452892691a7cbd4e0295&rfr_iscdi=true |