Ethanol extract from Astilbe chinensis inflorescence suppresses inflammation in macrophages and growth of oral pathogenic bacteria
Chronic oral inflammation and biofilm-mediated infections drive diseases such as dental caries and periodontitis. This study investigated the anti-inflammatory and antibacterial potential of an ethanol extract from Astilbe chinensis inflorescence (GA-13-6) as a prominent candidate for natural comple...
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| creator | Han, Jong Min Yun, Ina Yang, Kyung Mi Kim, Hye-Sung Kim, Young-Youn Jeong, Wonsik Hong, Seong Su Hwang, Inseong |
| description | Chronic oral inflammation and biofilm-mediated infections drive diseases such as dental caries and periodontitis. This study investigated the anti-inflammatory and antibacterial potential of an ethanol extract from Astilbe chinensis inflorescence (GA-13-6) as a prominent candidate for natural complex substances (NCS) with therapeutic potential. In LPS-stimulated RAW 264.7 macrophages, GA-13-6 significantly suppressed proinflammatory mediators, including interleukin-6 (IL-6), tumor necrosis factor (TNF), and nitric oxide (NO), surpassing purified astilbin, a known bioactive compound found in A. chinensis. Furthermore, GA-13-6 downregulated the expression of cyclooxygenase-2 (COX2) and inducible nitric oxide synthase (iNOS), indicating an inhibitory effect on the inflammatory cascade. Remarkably, GA-13-6 exhibited selective antibacterial activity against Streptococcus mutans, Streptococcus sanguinis, and Porphyromonas gingivalis, key players in dental caries and periodontitis, respectively. These findings suggest that complex GA-13-6 holds the potential for the treatment or prevention of periodontal and dental diseases, as well as various other inflammation-related conditions, while averting the induction of antibiotic resistance. |
| doi_str_mv | 10.1371/journal.pone.0306543 |
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This study investigated the anti-inflammatory and antibacterial potential of an ethanol extract from Astilbe chinensis inflorescence (GA-13-6) as a prominent candidate for natural complex substances (NCS) with therapeutic potential. In LPS-stimulated RAW 264.7 macrophages, GA-13-6 significantly suppressed proinflammatory mediators, including interleukin-6 (IL-6), tumor necrosis factor (TNF), and nitric oxide (NO), surpassing purified astilbin, a known bioactive compound found in A. chinensis. Furthermore, GA-13-6 downregulated the expression of cyclooxygenase-2 (COX2) and inducible nitric oxide synthase (iNOS), indicating an inhibitory effect on the inflammatory cascade. Remarkably, GA-13-6 exhibited selective antibacterial activity against Streptococcus mutans, Streptococcus sanguinis, and Porphyromonas gingivalis, key players in dental caries and periodontitis, respectively. These findings suggest that complex GA-13-6 holds the potential for the treatment or prevention of periodontal and dental diseases, as well as various other inflammation-related conditions, while averting the induction of antibiotic resistance.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0306543</identifier><identifier>PMID: 38959234</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acetaldehyde ; Acids ; Alcohol ; Alcohol, Denatured ; Animals ; Anti-Bacterial Agents - pharmacology ; Anti-Inflammatory Agents - pharmacology ; Antibacterial activity ; Antibacterial agents ; Antibiotic resistance ; Antibiotics ; Antibodies ; Antiinfectives and antibacterials ; Astilbe chinensis ; Bacteria ; Bioactive compounds ; Biofilms ; Biology and Life Sciences ; Cell culture ; Cyclooxygenase 2 - genetics ; Cyclooxygenase 2 - metabolism ; Cyclooxygenase-2 ; Dental caries ; Dental disorders ; Drug resistance ; Drug resistance in microorganisms ; Ethanol ; Ethanol - chemistry ; Ethylenediaminetetraacetic acid ; Gram-positive bacteria ; Gum disease ; Health aspects ; Inflammation ; Inflammation - drug therapy ; Inflorescence - chemistry ; Interleukin 6 ; Interleukin-6 - metabolism ; Interleukins ; Lipopolysaccharides ; Macrophages ; Macrophages - drug effects ; Macrophages - metabolism ; Medicine and Health Sciences ; Metronidazole ; Mice ; Nitric oxide ; Nitric Oxide - metabolism ; Nitric Oxide Synthase Type II - metabolism ; Nitric-oxide synthase ; Oral diseases ; Pathogens ; Periodontitis ; Phosphatase ; Physical Sciences ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; RAW 264.7 Cells ; Streptococcus infections ; Tumor necrosis factor ; Tumor Necrosis Factor-alpha - metabolism</subject><ispartof>PloS one, 2024-07, Vol.19 (7), p.e0306543</ispartof><rights>Copyright: © 2024 Han et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2024 Public Library of Science</rights><rights>2024 Han et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 Han et al 2024 Han et al</rights><rights>2024 Han et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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This study investigated the anti-inflammatory and antibacterial potential of an ethanol extract from Astilbe chinensis inflorescence (GA-13-6) as a prominent candidate for natural complex substances (NCS) with therapeutic potential. In LPS-stimulated RAW 264.7 macrophages, GA-13-6 significantly suppressed proinflammatory mediators, including interleukin-6 (IL-6), tumor necrosis factor (TNF), and nitric oxide (NO), surpassing purified astilbin, a known bioactive compound found in A. chinensis. Furthermore, GA-13-6 downregulated the expression of cyclooxygenase-2 (COX2) and inducible nitric oxide synthase (iNOS), indicating an inhibitory effect on the inflammatory cascade. Remarkably, GA-13-6 exhibited selective antibacterial activity against Streptococcus mutans, Streptococcus sanguinis, and Porphyromonas gingivalis, key players in dental caries and periodontitis, respectively. 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pharmacology</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Antibacterial activity</topic><topic>Antibacterial agents</topic><topic>Antibiotic resistance</topic><topic>Antibiotics</topic><topic>Antibodies</topic><topic>Antiinfectives and antibacterials</topic><topic>Astilbe chinensis</topic><topic>Bacteria</topic><topic>Bioactive compounds</topic><topic>Biofilms</topic><topic>Biology and Life Sciences</topic><topic>Cell culture</topic><topic>Cyclooxygenase 2 - genetics</topic><topic>Cyclooxygenase 2 - metabolism</topic><topic>Cyclooxygenase-2</topic><topic>Dental caries</topic><topic>Dental disorders</topic><topic>Drug resistance</topic><topic>Drug resistance in microorganisms</topic><topic>Ethanol</topic><topic>Ethanol - chemistry</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>Gram-positive bacteria</topic><topic>Gum disease</topic><topic>Health aspects</topic><topic>Inflammation</topic><topic>Inflammation - drug therapy</topic><topic>Inflorescence - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Han, Jong Min</au><au>Yun, Ina</au><au>Yang, Kyung Mi</au><au>Kim, Hye-Sung</au><au>Kim, Young-Youn</au><au>Jeong, Wonsik</au><au>Hong, Seong Su</au><au>Hwang, Inseong</au><au>Park, Wan-su</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ethanol extract from Astilbe chinensis inflorescence suppresses inflammation in macrophages and growth of oral pathogenic bacteria</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2024-07-03</date><risdate>2024</risdate><volume>19</volume><issue>7</issue><spage>e0306543</spage><pages>e0306543-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Chronic oral inflammation and biofilm-mediated infections drive diseases such as dental caries and periodontitis. This study investigated the anti-inflammatory and antibacterial potential of an ethanol extract from Astilbe chinensis inflorescence (GA-13-6) as a prominent candidate for natural complex substances (NCS) with therapeutic potential. In LPS-stimulated RAW 264.7 macrophages, GA-13-6 significantly suppressed proinflammatory mediators, including interleukin-6 (IL-6), tumor necrosis factor (TNF), and nitric oxide (NO), surpassing purified astilbin, a known bioactive compound found in A. chinensis. Furthermore, GA-13-6 downregulated the expression of cyclooxygenase-2 (COX2) and inducible nitric oxide synthase (iNOS), indicating an inhibitory effect on the inflammatory cascade. Remarkably, GA-13-6 exhibited selective antibacterial activity against Streptococcus mutans, Streptococcus sanguinis, and Porphyromonas gingivalis, key players in dental caries and periodontitis, respectively. These findings suggest that complex GA-13-6 holds the potential for the treatment or prevention of periodontal and dental diseases, as well as various other inflammation-related conditions, while averting the induction of antibiotic resistance.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>38959234</pmid><doi>10.1371/journal.pone.0306543</doi><tpages>e0306543</tpages><orcidid>https://orcid.org/0000-0002-4973-6823</orcidid><orcidid>https://orcid.org/0000-0002-2498-7546</orcidid><oa>free_for_read</oa></addata></record> |
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| issn | 1932-6203 1932-6203 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Acetaldehyde Acids Alcohol Alcohol, Denatured Animals Anti-Bacterial Agents - pharmacology Anti-Inflammatory Agents - pharmacology Antibacterial activity Antibacterial agents Antibiotic resistance Antibiotics Antibodies Antiinfectives and antibacterials Astilbe chinensis Bacteria Bioactive compounds Biofilms Biology and Life Sciences Cell culture Cyclooxygenase 2 - genetics Cyclooxygenase 2 - metabolism Cyclooxygenase-2 Dental caries Dental disorders Drug resistance Drug resistance in microorganisms Ethanol Ethanol - chemistry Ethylenediaminetetraacetic acid Gram-positive bacteria Gum disease Health aspects Inflammation Inflammation - drug therapy Inflorescence - chemistry Interleukin 6 Interleukin-6 - metabolism Interleukins Lipopolysaccharides Macrophages Macrophages - drug effects Macrophages - metabolism Medicine and Health Sciences Metronidazole Mice Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase Type II - metabolism Nitric-oxide synthase Oral diseases Pathogens Periodontitis Phosphatase Physical Sciences Plant Extracts - chemistry Plant Extracts - pharmacology RAW 264.7 Cells Streptococcus infections Tumor necrosis factor Tumor Necrosis Factor-alpha - metabolism |
| title | Ethanol extract from Astilbe chinensis inflorescence suppresses inflammation in macrophages and growth of oral pathogenic bacteria |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T23%3A40%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Ethanol%20extract%20from%20Astilbe%20chinensis%20inflorescence%20suppresses%20inflammation%20in%20macrophages%20and%20growth%20of%20oral%20pathogenic%20bacteria&rft.jtitle=PloS%20one&rft.au=Han,%20Jong%20Min&rft.date=2024-07-03&rft.volume=19&rft.issue=7&rft.spage=e0306543&rft.pages=e0306543-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0306543&rft_dat=%3Cgale_plos_%3EA799964237%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3075640762&rft_id=info:pmid/38959234&rft_galeid=A799964237&rfr_iscdi=true |