Recombinant Art v4.01 protein produces immunological tolerance by subcutaneous immunotherapy in a wormwood pollen-driven allergic asthma female mouse model

Art v4.01 is a well-known profilin protein belonging to the pan-allergens group and is commonly involved in triggering allergic asthma, polyallergy, and cross-sensitization. It is also referred to as Wormwood due to its origin. Crude wormwood extracts are applied for allergen-specific immunotherapy...

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Veröffentlicht in:	PloS one 2024-06, Vol.19 (6), p.e0280418
Hauptverfasser:	Wang, Tao, Chi, Jiaoni, Li, Zhimin, Zhang, Yue, Wang, Yaojun, Ding, Ming, Zhou, Bin, Gui, JiaChen, Li, Qiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergens Allergens - immunology Allergies Analysis Animals Asthma Asthma - immunology Asthma - therapy Bronchoalveolar Lavage Fluid - immunology Bronchus Cytokines Cytokines - metabolism Desensitization, Immunologic - methods Disease Models, Animal E coli Enzyme-linked immunosorbent assay Female Females Helper cells Immune response Immune system Immune Tolerance Immunoglobulin E Immunoglobulin E - blood Immunoglobulin E - immunology Immunological tolerance Immunology Immunotherapy In vivo methods and tests Inflammation Injections, Subcutaneous Interleukin 4 Interleukins Lavage Leukocytes Lungs Lymphocytes T Mice Mice, Inbred BALB C Monocytes Pathogens Pets Phenotypes Pneumonitis Pollen Pollen - immunology Profilin Profilins - immunology Proteins Recombinant Proteins - immunology Vaccines
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