Cell cycle regulation of the psoriasis associated gene CCHCR1 by transcription factor E2F1
The coiled-coil alpha-helical rod protein 1 (CCHCR1) was first identified as a candidate gene in psoriasis and has lately been found to be associated with a wide range of clinical conditions including COVID-19. CCHCR1 is located within P-bodies and centrosomes, but its exact role in these two subcel...
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| description | The coiled-coil alpha-helical rod protein 1 (CCHCR1) was first identified as a candidate gene in psoriasis and has lately been found to be associated with a wide range of clinical conditions including COVID-19. CCHCR1 is located within P-bodies and centrosomes, but its exact role in these two subcellular structures and its transcriptional control remain largely unknown. Here, we showed that CCHCR1 shares a bidirectional promoter with its neighboring gene, TCF19. This bidirectional promoter is activated by the G1/S-regulatory transcription factor E2F1, and both genes are co-induced during the G1/S transition of the cell cycle. A luciferase reporter assay suggests that the short intergenic sequence, only 287 bp in length, is sufficient for the G1/S induction of both genes, but the expression of CCHCR1 is further enhanced by the presence of exon 1 from both TCF19 and CCHCR1. This research uncovers the transcriptional regulation of the CCHCR1 gene, offering new perspectives on its function. These findings contribute to the broader understanding of diseases associated with CCHCR1 and may serve as a foundational benchmark for future research in these vital medical fields. |
| doi_str_mv | 10.1371/journal.pone.0294661 |
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CCHCR1 is located within P-bodies and centrosomes, but its exact role in these two subcellular structures and its transcriptional control remain largely unknown. Here, we showed that CCHCR1 shares a bidirectional promoter with its neighboring gene, TCF19. This bidirectional promoter is activated by the G1/S-regulatory transcription factor E2F1, and both genes are co-induced during the G1/S transition of the cell cycle. A luciferase reporter assay suggests that the short intergenic sequence, only 287 bp in length, is sufficient for the G1/S induction of both genes, but the expression of CCHCR1 is further enhanced by the presence of exon 1 from both TCF19 and CCHCR1. This research uncovers the transcriptional regulation of the CCHCR1 gene, offering new perspectives on its function. These findings contribute to the broader understanding of diseases associated with CCHCR1 and may serve as a foundational benchmark for future research in these vital medical fields.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0294661</identifier><identifier>PMID: 38128007</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Alopecia ; Baldness ; Biology and Life Sciences ; Cell cycle ; Centrosomes ; COVID-19 ; Diabetes ; Diagnosis ; Evaluation ; Gene expression ; Gene regulation ; Genes ; Genetic aspects ; Protein structure ; Psoriasis ; Regulatory sequences ; Research and Analysis Methods ; Skin diseases ; Transcription factors</subject><ispartof>PloS one, 2023-12, Vol.18 (12), p.e0294661-e0294661</ispartof><rights>Copyright: © 2023 Ling et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2023 Public Library of Science</rights><rights>2023 Ling et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 Ling et al 2023 Ling et al</rights><rights>2023 Ling et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c576t-bfc3af82c330b62cb91c183c049f664df89179a3f3719130309e7bfc772b03003</cites><orcidid>0000-0002-7030-7759</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10734992/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10734992/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38128007$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Prigent, Claude</contributor><creatorcontrib>Ling, Yick Hin</creatorcontrib><creatorcontrib>Chen, Yingying</creatorcontrib><creatorcontrib>Leung, Kwok Nam</creatorcontrib><creatorcontrib>Chan, King Ming</creatorcontrib><creatorcontrib>Liu, W K</creatorcontrib><title>Cell cycle regulation of the psoriasis associated gene CCHCR1 by transcription factor E2F1</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The coiled-coil alpha-helical rod protein 1 (CCHCR1) was first identified as a candidate gene in psoriasis and has lately been found to be associated with a wide range of clinical conditions including COVID-19. CCHCR1 is located within P-bodies and centrosomes, but its exact role in these two subcellular structures and its transcriptional control remain largely unknown. Here, we showed that CCHCR1 shares a bidirectional promoter with its neighboring gene, TCF19. This bidirectional promoter is activated by the G1/S-regulatory transcription factor E2F1, and both genes are co-induced during the G1/S transition of the cell cycle. A luciferase reporter assay suggests that the short intergenic sequence, only 287 bp in length, is sufficient for the G1/S induction of both genes, but the expression of CCHCR1 is further enhanced by the presence of exon 1 from both TCF19 and CCHCR1. This research uncovers the transcriptional regulation of the CCHCR1 gene, offering new perspectives on its function. These findings contribute to the broader understanding of diseases associated with CCHCR1 and may serve as a foundational benchmark for future research in these vital medical fields.</description><subject>Alopecia</subject><subject>Baldness</subject><subject>Biology and Life Sciences</subject><subject>Cell cycle</subject><subject>Centrosomes</subject><subject>COVID-19</subject><subject>Diabetes</subject><subject>Diagnosis</subject><subject>Evaluation</subject><subject>Gene expression</subject><subject>Gene regulation</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Protein structure</subject><subject>Psoriasis</subject><subject>Regulatory sequences</subject><subject>Research and Analysis Methods</subject><subject>Skin diseases</subject><subject>Transcription 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K</au><au>Prigent, Claude</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cell cycle regulation of the psoriasis associated gene CCHCR1 by transcription factor E2F1</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2023-12-21</date><risdate>2023</risdate><volume>18</volume><issue>12</issue><spage>e0294661</spage><epage>e0294661</epage><pages>e0294661-e0294661</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The coiled-coil alpha-helical rod protein 1 (CCHCR1) was first identified as a candidate gene in psoriasis and has lately been found to be associated with a wide range of clinical conditions including COVID-19. CCHCR1 is located within P-bodies and centrosomes, but its exact role in these two subcellular structures and its transcriptional control remain largely unknown. Here, we showed that CCHCR1 shares a bidirectional promoter with its neighboring gene, TCF19. This bidirectional promoter is activated by the G1/S-regulatory transcription factor E2F1, and both genes are co-induced during the G1/S transition of the cell cycle. A luciferase reporter assay suggests that the short intergenic sequence, only 287 bp in length, is sufficient for the G1/S induction of both genes, but the expression of CCHCR1 is further enhanced by the presence of exon 1 from both TCF19 and CCHCR1. This research uncovers the transcriptional regulation of the CCHCR1 gene, offering new perspectives on its function. These findings contribute to the broader understanding of diseases associated with CCHCR1 and may serve as a foundational benchmark for future research in these vital medical fields.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>38128007</pmid><doi>10.1371/journal.pone.0294661</doi><tpages>e0294661</tpages><orcidid>https://orcid.org/0000-0002-7030-7759</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Alopecia Baldness Biology and Life Sciences Cell cycle Centrosomes COVID-19 Diabetes Diagnosis Evaluation Gene expression Gene regulation Genes Genetic aspects Protein structure Psoriasis Regulatory sequences Research and Analysis Methods Skin diseases Transcription factors |
| title | Cell cycle regulation of the psoriasis associated gene CCHCR1 by transcription factor E2F1 |
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