Lactate-induced histone lactylation by p300 promotes osteoblast differentiation

Lactate, which is synthesized as an end product by lactate dehydrogenase A (LDHA) from pyruvate during anaerobic glycolysis, has attracted attention for its energy metabolism and oxidant effects. A novel histone modification-mediated gene regulation mechanism termed lactylation by lactate was recent...

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Veröffentlicht in:	PloS one 2023-12, Vol.18 (12), p.e0293676-e0293676
Hauptverfasser:	Minami, Erika, Sasa, Kiyohito, Yamada, Atsushi, Kawai, Ryota, Yoshida, Hiroshi, Nakano, Haruhisa, Maki, Koutaro, Kamijo, Ryutaro
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone morphogenetic protein 2 Cbfa-1 protein Cell Differentiation Dehydrogenases Dextrose Differentiation DNA methylation Energy metabolism Enzymes Epigenetics Gene expression Gene regulation Genes Glucose Glucose - metabolism Glucose - pharmacology Glycolysis Health aspects Histones Histones - metabolism L-Lactate dehydrogenase Lactate dehydrogenase Lactates Lactic acid Lactic Acid - metabolism Lactic Acid - pharmacology Metabolism Metabolites Osteoblastogenesis Osteoblasts Osteoblasts - metabolism Oxidants Oxidizing agents Phosphatase Physiological aspects Proteins Pyruvic acid Synthesis Tumorigenesis
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