Targeted metabolomics reveals the association between central carbon metabolism and pulmonary nodules
With the widespread application of low-dose computed tomography (LDCT) technology, pulmonary nodules have aroused more attention. Significant alteration in plasma metabolite levels, mainly amino acid and lipid, have been observed in patients of PNs. However, evidence on the association between centr...
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| Veröffentlicht in: | PloS one 2023-12, Vol.18 (12), p.e0295276 |
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| description | With the widespread application of low-dose computed tomography (LDCT) technology, pulmonary nodules have aroused more attention. Significant alteration in plasma metabolite levels, mainly amino acid and lipid, have been observed in patients of PNs. However, evidence on the association between central carbon metabolism and PNs are largely unknown. The aim of this study was to investigate the underlying association of PNs and plasma central carbon metabolites. We measured the levels of 16 plasma central carbon metabolites in 1954 participants who gained LDCT screening in MALSC cohort. The inverse probability weighting (IPW) technique was used to control for bias due to self-selection for LDCT in the assessed high-risk population. The least absolute shrinkage and selection operator (LASSO) penalized regression was used to deal with the problem of multicollinearity among metabolites and the combined association of central carbon metabolites with PNs was estimated by using quantile g-computation (QgC) models. A quartile increase in 3-hydroxybutyric acid, gluconic acid, succinic acid and hippuric acid was positively associated with the PNs risk, whereas a quartile increase in 2-oxadipic acid and fumaric acid was negatively associated with the risk of PNs in multiple-metabolite models. A positive but insignificant joint associations of the mixture of 16 metabolites with PNs was observed by using QgC models analyses. Further studies are warranted to clarify the association between circulating metabolites and PNs and the biological mechanisms. |
| doi_str_mv | 10.1371/journal.pone.0295276 |
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Significant alteration in plasma metabolite levels, mainly amino acid and lipid, have been observed in patients of PNs. However, evidence on the association between central carbon metabolism and PNs are largely unknown. The aim of this study was to investigate the underlying association of PNs and plasma central carbon metabolites. We measured the levels of 16 plasma central carbon metabolites in 1954 participants who gained LDCT screening in MALSC cohort. The inverse probability weighting (IPW) technique was used to control for bias due to self-selection for LDCT in the assessed high-risk population. The least absolute shrinkage and selection operator (LASSO) penalized regression was used to deal with the problem of multicollinearity among metabolites and the combined association of central carbon metabolites with PNs was estimated by using quantile g-computation (QgC) models. A quartile increase in 3-hydroxybutyric acid, gluconic acid, succinic acid and hippuric acid was positively associated with the PNs risk, whereas a quartile increase in 2-oxadipic acid and fumaric acid was negatively associated with the risk of PNs in multiple-metabolite models. A positive but insignificant joint associations of the mixture of 16 metabolites with PNs was observed by using QgC models analyses. Further studies are warranted to clarify the association between circulating metabolites and PNs and the biological mechanisms.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0295276</identifier><identifier>PMID: 38060623</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Amino acids ; Analysis ; Carbon ; Care and treatment ; Chronic obstructive pulmonary disease ; Computed tomography ; Diagnosis ; Ethylenediaminetetraacetic acid ; Family medical history ; Fumaric acid ; Gluconic acid ; Health aspects ; Hippuric acid ; Lipid metabolism ; Lipids ; Lung cancer ; Lung diseases ; Lung nodules ; Metabolites ; Metabolomics ; Nodules ; Population decline ; Quartiles ; Regression analysis ; Statistical analysis ; Succinic acid ; Tuberculosis</subject><ispartof>PloS one, 2023-12, Vol.18 (12), p.e0295276</ispartof><rights>Copyright: © 2023 Wu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2023 Public Library of Science</rights><rights>2023 Wu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 Wu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c586t-f3756d43e4f3a0e031ee2204a68b9efc81ae2a5b58595db09847964d43ff04a43</cites><orcidid>0000-0003-2127-3668</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0295276&type=printable$$EPDF$$P50$$Gplos$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0295276$$EHTML$$P50$$Gplos$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,860,2095,2914,23846,27903,27904,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38060623$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Mienda, Bashir Sajo</contributor><creatorcontrib>Wu, Yue-Yang</creatorcontrib><creatorcontrib>Shen, Wen-Bin</creatorcontrib><creatorcontrib>Li, Jian-Wei</creatorcontrib><creatorcontrib>Liu, Meng-Yu</creatorcontrib><creatorcontrib>Hu, Wen-Lei</creatorcontrib><creatorcontrib>Wang, Sheng</creatorcontrib><creatorcontrib>Liu, Jian-Jun</creatorcontrib><creatorcontrib>Huang, Fen</creatorcontrib><creatorcontrib>Qin, Qi-Rong</creatorcontrib><title>Targeted metabolomics reveals the association between central carbon metabolism and pulmonary nodules</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>With the widespread application of low-dose computed tomography (LDCT) technology, pulmonary nodules have aroused more attention. Significant alteration in plasma metabolite levels, mainly amino acid and lipid, have been observed in patients of PNs. However, evidence on the association between central carbon metabolism and PNs are largely unknown. The aim of this study was to investigate the underlying association of PNs and plasma central carbon metabolites. We measured the levels of 16 plasma central carbon metabolites in 1954 participants who gained LDCT screening in MALSC cohort. The inverse probability weighting (IPW) technique was used to control for bias due to self-selection for LDCT in the assessed high-risk population. The least absolute shrinkage and selection operator (LASSO) penalized regression was used to deal with the problem of multicollinearity among metabolites and the combined association of central carbon metabolites with PNs was estimated by using quantile g-computation (QgC) models. A quartile increase in 3-hydroxybutyric acid, gluconic acid, succinic acid and hippuric acid was positively associated with the PNs risk, whereas a quartile increase in 2-oxadipic acid and fumaric acid was negatively associated with the risk of PNs in multiple-metabolite models. A positive but insignificant joint associations of the mixture of 16 metabolites with PNs was observed by using QgC models analyses. Further studies are warranted to clarify the association between circulating metabolites and PNs and the biological mechanisms.</description><subject>Amino acids</subject><subject>Analysis</subject><subject>Carbon</subject><subject>Care and treatment</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Computed tomography</subject><subject>Diagnosis</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Family medical history</subject><subject>Fumaric acid</subject><subject>Gluconic acid</subject><subject>Health aspects</subject><subject>Hippuric acid</subject><subject>Lipid metabolism</subject><subject>Lipids</subject><subject>Lung cancer</subject><subject>Lung diseases</subject><subject>Lung nodules</subject><subject>Metabolites</subject><subject>Metabolomics</subject><subject>Nodules</subject><subject>Population decline</subject><subject>Quartiles</subject><subject>Regression analysis</subject><subject>Statistical analysis</subject><subject>Succinic 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metabolomics reveals the association between central carbon metabolism and pulmonary nodules</title><author>Wu, Yue-Yang ; Shen, Wen-Bin ; Li, Jian-Wei ; Liu, Meng-Yu ; Hu, Wen-Lei ; Wang, Sheng ; Liu, Jian-Jun ; Huang, Fen ; Qin, Qi-Rong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c586t-f3756d43e4f3a0e031ee2204a68b9efc81ae2a5b58595db09847964d43ff04a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Amino acids</topic><topic>Analysis</topic><topic>Carbon</topic><topic>Care and treatment</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Computed tomography</topic><topic>Diagnosis</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>Family medical history</topic><topic>Fumaric acid</topic><topic>Gluconic acid</topic><topic>Health aspects</topic><topic>Hippuric acid</topic><topic>Lipid metabolism</topic><topic>Lipids</topic><topic>Lung 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Significant alteration in plasma metabolite levels, mainly amino acid and lipid, have been observed in patients of PNs. However, evidence on the association between central carbon metabolism and PNs are largely unknown. The aim of this study was to investigate the underlying association of PNs and plasma central carbon metabolites. We measured the levels of 16 plasma central carbon metabolites in 1954 participants who gained LDCT screening in MALSC cohort. The inverse probability weighting (IPW) technique was used to control for bias due to self-selection for LDCT in the assessed high-risk population. The least absolute shrinkage and selection operator (LASSO) penalized regression was used to deal with the problem of multicollinearity among metabolites and the combined association of central carbon metabolites with PNs was estimated by using quantile g-computation (QgC) models. A quartile increase in 3-hydroxybutyric acid, gluconic acid, succinic acid and hippuric acid was positively associated with the PNs risk, whereas a quartile increase in 2-oxadipic acid and fumaric acid was negatively associated with the risk of PNs in multiple-metabolite models. A positive but insignificant joint associations of the mixture of 16 metabolites with PNs was observed by using QgC models analyses. Further studies are warranted to clarify the association between circulating metabolites and PNs and the biological mechanisms.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>38060623</pmid><doi>10.1371/journal.pone.0295276</doi><tpages>e0295276</tpages><orcidid>https://orcid.org/0000-0003-2127-3668</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Amino acids Analysis Carbon Care and treatment Chronic obstructive pulmonary disease Computed tomography Diagnosis Ethylenediaminetetraacetic acid Family medical history Fumaric acid Gluconic acid Health aspects Hippuric acid Lipid metabolism Lipids Lung cancer Lung diseases Lung nodules Metabolites Metabolomics Nodules Population decline Quartiles Regression analysis Statistical analysis Succinic acid Tuberculosis |
| title | Targeted metabolomics reveals the association between central carbon metabolism and pulmonary nodules |
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