Network pharmacology and experimental verification to decode the action of Qing Fei Hua Xian Decotion against pulmonary fibrosis

Pulmonary fibrosis (PF) is a common interstitial pneumonia disease, also occurred in post-COVID-19 survivors. The mechanism underlying the anti-PF effect of Qing Fei Hua Xian Decotion (QFHXD), a traditional Chinese medicine formula applied for treating PF in COVID-19 survivors, is unclear. This stud...

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Veröffentlicht in:	PloS one 2024-06, Vol.19 (6), p.e0305903
Hauptverfasser:	Ke, Hao-Liang, Li, Rui-Jie, Yu, Chao-Chao, Wang, Xiu-Ping, Wu, Chao-Yan, Zhang, Ying-Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Animals Bioinformatics Biology and Life Sciences Bleomycin Chemical compounds Chinese medicine Computed tomography Computer and Information Sciences COVID-19 COVID-19 - metabolism COVID-19 Drug Treatment Drugs, Chinese Herbal - pharmacology Drugs, Chinese Herbal - therapeutic use Epithelial-Mesenchymal Transition - drug effects Extracellular matrix Fibrosis Gelatinase B Genes Herbal medicine Humans Inflammation Laboratory animals Lung diseases Male Medicine and Health Sciences Medicine, Chinese Traditional - methods Network analysis Network Pharmacology NF-κB protein Pharmaceuticals Pharmacology Prednisone Protein Interaction Maps - drug effects Proteins Pulmonary fibrosis Pulmonary Fibrosis - chemically induced Pulmonary Fibrosis - drug therapy Pulmonary Fibrosis - metabolism Pulmonary Fibrosis - pathology Rats Rats, Sprague-Dawley Signal Transduction - drug effects Smad2 protein Staining Stat3 protein Therapeutic targets Traditional Chinese medicine Transforming Growth Factor beta1 - metabolism Transforming growth factor-b1 Verification
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