Effects of allopurinol and febuxostat on uric acid transport and transporter expression in human umbilical vein endothelial cells

Uric acid induces radical oxygen species formation, endothelial inflammation, and endothelial dysfunction which contributes to the progression of atherosclerosis. Febuxostat inhibits BCRP- and allopurinol stimulates MRP4-mediated uric acid efflux in human embryonic kidney cells. We hypothesized that...

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Veröffentlicht in:	PloS one 2024-06, Vol.19 (6), p.e0305906
Hauptverfasser:	van der Pol, Karel H, Koenderink, Jan, van den Heuvel, Jeroen J M W, van den Broek, Petra, Peters, Janny, van Bunningen, Imke D W, Pertijs, Jeanne, Russel, Frans G M, Koldenhof, Jim, Morshuis, Wim J, van Drongelen, Joris, Schirris, Tom J J, van der Meer, Andries, Rongen, Gerard A
Format:	Artikel
Sprache:	eng
Schlagworte:	Allopurinol Allopurinol - pharmacology Analysis Arteriosclerosis Atherosclerosis Biological Transport - drug effects Biology and Life Sciences Cardiovascular diseases Clinical trials Development and progression Disease Efflux Endothelial cells Endothelium Epidermal growth factor Febuxostat - pharmacology Gene expression Gene Expression Regulation - drug effects Glucose Glucose Transport Proteins, Facilitative - genetics Glucose Transport Proteins, Facilitative - metabolism Health aspects Hospitals Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Humans Inflammation Intracellular Kidneys Medicine and Health Sciences Mortality Multidrug Resistance-Associated Proteins - genetics Multidrug Resistance-Associated Proteins - metabolism Penicillin Physical Sciences Proteins RNA RNA, Messenger - genetics RNA, Messenger - metabolism Thoracic surgery Umbilical cord Umbilical vein Uric acid Uric Acid - metabolism Veins & arteries
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