Evaluation of pharmacokinetics, safety, and efficacy of [211At] meta-astatobenzylguanidine ([211At] MABG) in patients with pheochromocytoma or paraganglioma (PPGL): A study protocol

Pheochromocytoma, or paraganglioma (PPGL), is a tumor that arises from catecholamine-producing chromaffin cells of the adrenal medulla or paraganglion. Systemic therapy, such as the combination of cyclophosphamide, vincristine, and dacarbazine or therapeutic radiopharmaceuticals such as [131I] meta-...

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Veröffentlicht in:	PloS one 2024-05, Vol.19 (5), p.e0303623-e0303623
Hauptverfasser:	Kobayakawa, Masao, Shiga, Tohru, Takahashi, Kazuhiro, Sugawara, Shigeyasu, Nomura, Kaori, Hanada, Kazuhiko, Ishizuka, Naoki, Ito, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Gland Neoplasms - diagnostic imaging Adrenal Gland Neoplasms - drug therapy Adrenal Gland Neoplasms - metabolism Adrenal Gland Neoplasms - pathology Adrenal medulla Adult Aged Biology and Life Sciences Cancer Catecholamine Catecholamines Chromaffin cells Clinical trials Clinical Trials, Phase I as Topic Committees Constraining Cyclophosphamide Dacarbazine Drug dosages Effectiveness Female Guanidines - pharmacokinetics Guanidines - therapeutic use Hematology Humans Male Medicine and Health Sciences Metastases Middle Aged Paraganglioma Paraganglioma - diagnostic imaging Paraganglioma - drug therapy Paraganglioma - metabolism Paraganglioma - pathology Pharmacokinetics Pheochromocytoma - diagnostic imaging Pheochromocytoma - drug therapy Pheochromocytoma - metabolism Pheochromocytoma - pathology Pheochromocytoma cells Quality of life Radioisotopes Radiopharmaceuticals - pharmacokinetics Research and Analysis Methods Response rates Safety Scintigraphy Study Protocol Toxicity Treatment Outcome Tumors Vincristine
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