Frailty and risk of systemic atherosclerosis: A bidirectional Mendelian randomization study

Numerous observational studies have reported an association between frailty and atherosclerosis. However, the causal relationship between frailty and the occurrence of atherosclerosis in different anatomical sites remains unclear. we conducted a bidirectional Mendelian randomization (MR) study to ev...

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Veröffentlicht in:	PloS one 2024-05, Vol.19 (5), p.e0304300-e0304300
Hauptverfasser:	Xu, Liugang, Wang, Yajun, Ji, Hongyun, Du, Wei, You, Chunhui, Chen, Jin, Jiang, Jianyu, Shan, Yisi, Pan, Qian, Cao, Ruihong
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Arteriosclerosis Atherosclerosis Atherosclerosis - genetics Biobanks Biology and Life Sciences Cardiovascular disease Cholesterol, HDL - blood Cholesterol, LDL - blood Chronic illnesses Confounding (Statistics) Coronary Artery Disease - genetics Coronary vessels Epidemiology Estimates Female Frailty Frailty - genetics Genome-wide association studies Genome-Wide Association Study Genomes Genomics High density lipoprotein Humans Hypotheses Ischemia Lipids Low density lipoprotein Low density lipoproteins Male Medicine and Health Sciences Mendelian Randomization Analysis Multivariate analysis Observational studies Phenotypes Polymorphism, Single Nucleotide Randomization Risk Risk Factors Statistical analysis Statistics Triglycerides Triglycerides - blood Variables Veins & arteries
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