Prognostic effect of osteoprotegerin in patients with ischemic stroke: A systematic review and meta-analysis
Osteoprotegerin (OPG) is supposed to participate in the development of atherosclerosis and cardio-cerebrovascular disease. However, the results of research on relationship between OPG and ischemic stroke (IS) are controversial. Therefore, we carried out the first systematic review and meta-analysis...
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| description | Osteoprotegerin (OPG) is supposed to participate in the development of atherosclerosis and cardio-cerebrovascular disease. However, the results of research on relationship between OPG and ischemic stroke (IS) are controversial. Therefore, we carried out the first systematic review and meta-analysis to evaluate prognostic effect of osteoprotegerin in patients with IS.
We comprehensively searched databases of PubMed, Embase, and the Cochrane Library through 21 August 2023 to identify observational studies that evaluated effect of OPG on poor functional outcome (modified Rankin Scale [mRS] Score of 3-6) and mortality in patients with IS. Adjusted odds ratios (aOR) with a 95% confidence interval (CI) of each included study were used as much as possible to assess the pooled effect.
Five studies that enrolled 4,506 patients in total fulfilled our inclusion criteria. Three studies were included in the pooled analysis for each endpoint since one of the included studies had provided data on poor functional outcome as well as mortality. OPG was neither associated with poor functional outcome (aOR 1.29, 95% CI 0.90-1.85) nor with mortality (aOR 1.57, 95% CI 0.90-2.74) in patients with IS.
There is insufficient evidence to demonstrate the correlation between OPG and mortality or poor functional outcome in IS patients. OPG cannot be applied to predict worse neurological function in IS patients based on the current evidence. |
| doi_str_mv | 10.1371/journal.pone.0303832 |
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We comprehensively searched databases of PubMed, Embase, and the Cochrane Library through 21 August 2023 to identify observational studies that evaluated effect of OPG on poor functional outcome (modified Rankin Scale [mRS] Score of 3-6) and mortality in patients with IS. Adjusted odds ratios (aOR) with a 95% confidence interval (CI) of each included study were used as much as possible to assess the pooled effect.
Five studies that enrolled 4,506 patients in total fulfilled our inclusion criteria. Three studies were included in the pooled analysis for each endpoint since one of the included studies had provided data on poor functional outcome as well as mortality. OPG was neither associated with poor functional outcome (aOR 1.29, 95% CI 0.90-1.85) nor with mortality (aOR 1.57, 95% CI 0.90-2.74) in patients with IS.
There is insufficient evidence to demonstrate the correlation between OPG and mortality or poor functional outcome in IS patients. OPG cannot be applied to predict worse neurological function in IS patients based on the current evidence.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0303832</identifier><identifier>PMID: 38820283</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Apoptosis ; Arteriosclerosis ; Atherosclerosis ; Biomarkers ; Cardiovascular disease ; Care and treatment ; Cerebrovascular diseases ; Development and progression ; Health aspects ; Heart failure ; Humans ; Inflammation ; Ischemia ; Ischemic Stroke - drug therapy ; Ischemic Stroke - mortality ; Ligands ; Medical prognosis ; Medical research ; Medicine, Experimental ; Meta-analysis ; Mortality ; Observational studies ; Osteoprotegerin ; Prognosis ; Sensitivity analysis ; Stroke ; Stroke (Disease) ; Systematic review ; TNF inhibitors ; Tumor necrosis factor-TNF</subject><ispartof>PloS one, 2024-05, Vol.19 (5), p.e0303832</ispartof><rights>Copyright: © 2024 Pang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2024 Public Library of Science</rights><rights>2024 Pang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 Pang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c586t-d74725c8ac085cd65208181f3ee64b8e524cb58c6c8e7e09d42dfb14ade0b2ee3</cites><orcidid>0009-0003-6005-4457</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0303832&type=printable$$EPDF$$P50$$Gplos$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0303832$$EHTML$$P50$$Gplos$$Hfree_for_read</linktohtml><link.rule.ids>314,777,781,861,2096,2915,23847,27905,27906,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38820283$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Dikmen, Tayfun</contributor><creatorcontrib>Pang, Linlin</creatorcontrib><creatorcontrib>Lin, Hongyu</creatorcontrib><creatorcontrib>Wei, Xinxian</creatorcontrib><creatorcontrib>Wei, Wenxin</creatorcontrib><creatorcontrib>Lan, Yu</creatorcontrib><title>Prognostic effect of osteoprotegerin in patients with ischemic stroke: A systematic review and meta-analysis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Osteoprotegerin (OPG) is supposed to participate in the development of atherosclerosis and cardio-cerebrovascular disease. However, the results of research on relationship between OPG and ischemic stroke (IS) are controversial. Therefore, we carried out the first systematic review and meta-analysis to evaluate prognostic effect of osteoprotegerin in patients with IS.
We comprehensively searched databases of PubMed, Embase, and the Cochrane Library through 21 August 2023 to identify observational studies that evaluated effect of OPG on poor functional outcome (modified Rankin Scale [mRS] Score of 3-6) and mortality in patients with IS. Adjusted odds ratios (aOR) with a 95% confidence interval (CI) of each included study were used as much as possible to assess the pooled effect.
Five studies that enrolled 4,506 patients in total fulfilled our inclusion criteria. Three studies were included in the pooled analysis for each endpoint since one of the included studies had provided data on poor functional outcome as well as mortality. OPG was neither associated with poor functional outcome (aOR 1.29, 95% CI 0.90-1.85) nor with mortality (aOR 1.57, 95% CI 0.90-2.74) in patients with IS.
There is insufficient evidence to demonstrate the correlation between OPG and mortality or poor functional outcome in IS patients. OPG cannot be applied to predict worse neurological function in IS patients based on the current evidence.</description><subject>Analysis</subject><subject>Apoptosis</subject><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>Biomarkers</subject><subject>Cardiovascular disease</subject><subject>Care and treatment</subject><subject>Cerebrovascular diseases</subject><subject>Development and progression</subject><subject>Health aspects</subject><subject>Heart failure</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Ischemia</subject><subject>Ischemic Stroke - drug therapy</subject><subject>Ischemic Stroke - mortality</subject><subject>Ligands</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Meta-analysis</subject><subject>Mortality</subject><subject>Observational 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One</addtitle><date>2024-05-31</date><risdate>2024</risdate><volume>19</volume><issue>5</issue><spage>e0303832</spage><pages>e0303832-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Osteoprotegerin (OPG) is supposed to participate in the development of atherosclerosis and cardio-cerebrovascular disease. However, the results of research on relationship between OPG and ischemic stroke (IS) are controversial. Therefore, we carried out the first systematic review and meta-analysis to evaluate prognostic effect of osteoprotegerin in patients with IS.
We comprehensively searched databases of PubMed, Embase, and the Cochrane Library through 21 August 2023 to identify observational studies that evaluated effect of OPG on poor functional outcome (modified Rankin Scale [mRS] Score of 3-6) and mortality in patients with IS. Adjusted odds ratios (aOR) with a 95% confidence interval (CI) of each included study were used as much as possible to assess the pooled effect.
Five studies that enrolled 4,506 patients in total fulfilled our inclusion criteria. Three studies were included in the pooled analysis for each endpoint since one of the included studies had provided data on poor functional outcome as well as mortality. OPG was neither associated with poor functional outcome (aOR 1.29, 95% CI 0.90-1.85) nor with mortality (aOR 1.57, 95% CI 0.90-2.74) in patients with IS.
There is insufficient evidence to demonstrate the correlation between OPG and mortality or poor functional outcome in IS patients. OPG cannot be applied to predict worse neurological function in IS patients based on the current evidence.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>38820283</pmid><doi>10.1371/journal.pone.0303832</doi><tpages>e0303832</tpages><orcidid>https://orcid.org/0009-0003-6005-4457</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Apoptosis Arteriosclerosis Atherosclerosis Biomarkers Cardiovascular disease Care and treatment Cerebrovascular diseases Development and progression Health aspects Heart failure Humans Inflammation Ischemia Ischemic Stroke - drug therapy Ischemic Stroke - mortality Ligands Medical prognosis Medical research Medicine, Experimental Meta-analysis Mortality Observational studies Osteoprotegerin Prognosis Sensitivity analysis Stroke Stroke (Disease) Systematic review TNF inhibitors Tumor necrosis factor-TNF |
| title | Prognostic effect of osteoprotegerin in patients with ischemic stroke: A systematic review and meta-analysis |
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