Polygenic risk score for acute rejection based on donor-recipient non-HLA genotype mismatch

Acute rejection (AR) after kidney transplantation is an important allograft complication. To reduce the risk of post-transplant AR, determination of kidney transplant donor-recipient mismatching focuses on blood type and human leukocyte antigens (HLA), while it remains unclear whether non-HLA geneti...

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Veröffentlicht in:	PloS one 2024-05, Vol.19 (5), p.e0303446
Hauptverfasser:	Cao, Rui, Schladt, David P, Dorr, Casey, Matas, Arthur J, Oetting, William S, Jacobson, Pamala A, Israni, Ajay, Chen, Jinbo, Guan, Weihua
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Algorithms Allografts Antigens Biological activity Biotechnology industry Blood groups Cohort Studies Donation of organs, tissues, etc Female Genes Genetic aspects Genetic Risk Score Genome-Wide Association Study Genomes Genomics Genotype Genotype & phenotype Graft rejection Graft Rejection - genetics Graft Rejection - immunology Histocompatibility antigen HLA Histocompatibility antigens HLA Antigens - genetics HLA histocompatibility antigens Humans Kidney Transplantation Kidney transplants Kidneys Living Donors Male Middle Aged Morphogenesis Multifactorial Inheritance Nucleotides Polymorphism, Single Nucleotide Quality control Rejection Risk Risk Factors Risk reduction Single nucleotide polymorphisms Single-nucleotide polymorphism Skin cancer Transplantation Type 2 diabetes
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