Proinsulin degradation and presentation of a proinsulin B-chain autoantigen involves ER-associated protein degradation (ERAD)-enzyme UBE2G2

Type 1 diabetes (T1D) is characterized by HLA class I-mediated presentation of autoantigens on the surface of pancreatic β-cells. Recognition of these autoantigens by CD8+ T cells results in the destruction of pancreatic β-cells and, consequently, insulin deficiency. Most epitopes presented at the s...

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Veröffentlicht in:	PloS one 2024-05, Vol.19 (5), p.e0287877
Hauptverfasser:	Cremer, Tom, Hoelen, Hanneke, van de Weijer, Michael L, Janssen, George M, Costa, Ana I, van Veelen, Peter A, Lebbink, Robert Jan, Wiertz, Emmanuel J H J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antigen presentation Antigen Presentation - immunology Antigenic determinants Autoantigens Autoantigens - immunology Autoantigens - metabolism Autoimmunity Beta cells Biodegradation CD8 antigen CRISPR Degradation Diabetes Diabetes mellitus (insulin dependent) Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - metabolism Endoplasmic Reticulum-Associated Degradation Enzymes Epitopes Ethylenediaminetetraacetic acid Genetic screening Humans Insulin Insulin-Secreting Cells - immunology Insulin-Secreting Cells - metabolism Lymphocytes Lymphocytes T Pancreas Pancreatic beta cells Pathogenesis Peptides Plasmids Proinsulin - genetics Proinsulin - immunology Proinsulin - metabolism Proteins Proteolysis Quality control Software T cells Target recognition Type 1 diabetes Ubiquitin Ubiquitin-conjugating enzyme Ubiquitin-Conjugating Enzymes - genetics Ubiquitin-Conjugating Enzymes - metabolism
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