Combined use of Panax notoginseng and leech provides new insights into renal fibrosis: Restoration of mitochondrial kinetic imbalance

In this study, we aimed to investigate the protective effects of Panax notoginseng and leech (PL) on renal fibrosis and explore the mechanisms underlying their actions. For this study, we created an adenine-induced renal fibrosis model in SD rats to investigate the protective effect of PL on renal f...

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Veröffentlicht in:	PloS one 2024-05, Vol.19 (5), p.e0303906-e0303906
Hauptverfasser:	Chen, Xin, Deng, Jingwei, Zuo, Ling, Luo, Hongyu, Wang, Munan, Deng, Peng, Yang, Kang, Yang, Qian, Huang, Xuekuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine Animals Biology and Life Sciences Collagen Cristae Disease Models, Animal Drinking water Drug dosages Electron microscopy Enzyme-linked immunosorbent assay Extracellular matrix Extracellular Matrix - metabolism Fibrosis Inflammation Kidney - drug effects Kidney - metabolism Kidney - pathology Kidney Diseases - metabolism Kidney Diseases - pathology Kidneys Leeches Male Medical research Medicine and Health Sciences Metabolism Mitochondria Mitochondria - drug effects Mitochondria - metabolism Mitochondrial Dynamics - drug effects Oxidative stress Oxidative Stress - drug effects Panax notoginseng Panax notoginseng - chemistry Pharmaceuticals Phosphorylation Proteins Rats Rats, Sprague-Dawley Renal function Transmission electron microscopy Urine
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