The short-chain fatty acid propionate prevents ox-LDL-induced coronary microvascular dysfunction by alleviating endoplasmic reticulum stress in HCMECs

Coronary microvascular dysfunction (CMD) is a critical pathogenesis of cardiovascular diseases. Lower endothelial nitric oxide synthase (eNOS) phosphorylation leads to reduced endothelium-derived relaxing factor nitric oxide (NO) generation, causing and accelerating CMD. Endoplasmic reticulum stress...

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Veröffentlicht in:	PloS one 2024-05, Vol.19 (5), p.e0304551
Hauptverfasser:	Hong, Dan, Tang, Wen, Li, Fei, Liu, Yating, Fu, Xiao, Xu, Qin
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factor 6 - metabolism Angina pectoris Arterioles Atherosclerosis Biology and Life Sciences Cardiology Cardiomyopathy Cardiovascular disease Cardiovascular diseases Coronary Vessels - drug effects Coronary Vessels - metabolism Development and progression eIF-2 Kinase - metabolism Endoplasmic reticulum Endoplasmic Reticulum Chaperone BiP Endoplasmic Reticulum Stress - drug effects Endothelial cells Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelium Endothelium-derived relaxing factors Fatty acids Fatty Acids, Volatile - metabolism Fatty Acids, Volatile - pharmacology Fermentation Heat-Shock Proteins - metabolism Humans Initiation factor eIF-2 Intestinal microflora Lipids Lipoproteins, LDL - metabolism Low density lipoprotein Low density lipoproteins Medicine and Health Sciences Metabolic disorders Microbiomes Microcirculation - drug effects Microvasculature Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase Type III - metabolism Nitric-oxide synthase Pathogenesis Phosphorylation Phosphorylation - drug effects Physical Sciences Prevention Propionates - pharmacology Propionic acid Protein expression Proteins Research and Analysis Methods Signal transduction Signal Transduction - drug effects Umbilical vein Vasodilation
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